Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors von Diamond, Jennifer R, Pitts, Todd M, Ungermannova, Dana, Nasveschuk, Christopher G, Zhang, Gan, Phillips, Andrew J, Bagby, Stacey M, Pafford, Jessica, Yacob, Betelehem W, Newton, Timothy P, Tentler, John J, Gittleman, Brian, Hartman, Sarah J, DeMattei, John A, Winkler, James D, Wendt, Michael K, Schiemann, William P, Eckhardt, S Gail, Liu, Xuedong, Piscopio, Anthony D

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First-in-Human Dose-Escalation Study of the Novel Oral Depsipeptide Class I-Targeting HDAC Inhibitor Bocodepsin (OKI-179) in Patients with Advanced Solid Tumors von Schreiber, Anna R, Kagihara, Jodi A, Corr, Bradley R, Davis, S Lindsey, Lieu, Christopher, Kim, Sunnie S, Jimeno, Antonio, Camidge, D Ross, Williams, Jud, Heim, Amy M, Martin, Anne, DeMattei, John A, Holay, Nisha, Triplett, Todd A, Eckhardt, S Gail, Litwiler, Kevin, Winkler, James, Piscopio, Anthony D, Diamond, Jennifer R

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Preparation of Pyrrolidine-Based PDE4 Inhibitors via Enantioselective Conjugate Addition of α-Substituted Malonates to Aromatic Nitroalkenes von Nichols, Paul J, DeMattei, John A, Barnett, Bradley R, LeFur, Nicole A, Chuang, Tsung-Hsun, Piscopio, Anthony D, Koch, Kevin

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Complete Relative Stereochemistry of Maitotoxin von Zheng, Wanjun, DeMattei, John A, Wu, Jiang-Ping, Duan, James J.-W, Cook, Laura R, Oinuma, Hitoshi, Kishi, Yoshito

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A Scaleable Synthesis of Fiduxosin von Haight, Anthony R, Bailey, Anne E, Baker, William S, Cain, Michael H, Copp, Richard R, DeMattei, John A, Ford, Kelley L, Henry, Rodger F, Hsu, Margaret C, Keyes, Robert F, King, Steven A, McLaughlin, Maureen A, Melcher, Laura M, Nadler, William R, Oliver, Patricia A, Parekh, Shyamal I, Patel, Hemant H, Seif, Louis S, Staeger, Mike A, Wayne, Gregory S, Wittenberger, Steven J, Zhang, Weijiang

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Abstract B007: OKI-179 is a novel, oral, class I specific histone deacetylase inhibitor in phase 1 clinical trials von Diamond, Jennifer R, Kagihara, Jodi A, Liu, Xuedong, Gordon, Gilad, Heim, Amy M, Winkler, James, DeMattei, John A, Piscopio, Anthony D, Eckhardt, S. Gail

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Allylation of Erythromycin Derivatives:  Introduction of Allyl Substituents into Highly Hindered Alcohols von Stoner, Eric J, Peterson, Matthew J, Allen, Michael S, DeMattei, John A, Haight, Anthony R, Leanna, M. Robert, Patel, Subhash R, Plata, Daniel J, Premchandran, Ramiya H, Rasmussen, Michael

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Phase 1 study of OKI-179, an oral class 1-selective depsipeptide HDAC inhibitor, in patients with advanced solid tumors: Final results von Kagihara, Jodi A., Corr, Bradley, Pacheco, Jose Maria, Davis, S. Lindsey, Lieu, Christopher Hanyoung, Kim, Sunnie S., Jimeno, Antonio, Heim, Amy M., DeMattei, John A., Gordon, Gilad, Triplett, Todd A., Eckhardt, S. Gail, Winkler, James D., Piscopio, Anthony D., Diamond, Jennifer Robinson

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An Efficient Synthesis of the Taxane-Derived Anticancer Agent ABT-271 von DeMattei, John A., Leanna, M. Robert, Li, Wenke, Nichols, Paul J., Rasmussen, Michael W., Morton, Howard E.

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Asymmetric Synthesis of Calyculin C. 1. Synthesis of the C1−C25 Fragment von Scarlato, Gerard R, DeMattei, John A, Chong, Lee S, Ogawa, Anthony K, Lin, Mavis R, Armstrong, Robert W

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Synthesis of the C-13 Side Chain Precursors of the 9-Dihydrotaxane Analogue ABT-271 von Leanna, M. Robert, DeMattei, John A, Li, Wenke, Nichols, Paul J, Rasmussen, Michael, Morton, Howard E

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Asymmetric Synthesis of Calyculin C. 2. Synthesis of the C26−C37 Fragment and Model Wittig Couplings von Ogawa, Anthony K, DeMattei, John A, Scarlato, Gerard R, Tellew, John E, Chong, Lee S, Armstrong, Robert W

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Asymmetric Synthesis of Calyculin C. 2. Synthesis of the C(26)-C(37) Fragment and Model Wittig Couplings von Ogawa, Anthony K., DeMattei, John A., Scarlato, Gerard R., Tellew, John E., Chong, Lee S., Armstrong, Robert W.

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Asymmetric Synthesis of Calyculin C. 1. Synthesis of the C(1)-C(25) Fragment von Scarlato, Gerard R., DeMattei, John A., Chong, Lee S., Ogawa, Anthony K., Lin, Mavis R., Armstrong, Robert W.

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Stereoselective methylations of bicyclic lactams derived from pyroglutamic acid von Armstrong, Robert W., DeMattei, John A.

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Asymmetric Synthesis of Calyculin C. 1. Synthesis of the C 1 −C 25 Fragment von Scarlato, Gerard R., DeMattei, John A., Chong, Lee S., Ogawa, Anthony K., Lin, Mavis R., Armstrong, Robert W.

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Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof von Sengupta, Dipanjan, Buzard, Daniel J, Johannsen, Stephen R, Gharbaoui, Tawfik, Martinelli, Michael John, Krishnan, Ashwin M, Ma, You-An, Kuhlman, Young Mi, Montalban, Antonio Garrido, DeMattei, John A, Sato, Suzanne Michiko

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PROCESSES FOR THE PREPARATION OF (R)-2-(7-(4-CYCLOPENTYL-3-(TRIFLUOROMETHYL)BENZYLOXY)-1,2,3,4-TETRAHYDROCYCLOPENTA[B]INDOL-3-YL)ACETIC ACID AND SALTS THEREOF von Sengupta, Dipanjan, Buzard, Daniel J, Johannsen, Stephen R, Gharbaoui, Tawfik, Martinelli, Michael John, Krishnan, Ashwin M, Ma, You-An, Kuhlman, Young Mi, Montalban, Antonio Garrido, DeMattei, John A, Sato, Suzanne Michiko

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Asymmetric Synthesis of Calyculin C. 2. Synthesis of the C 26 −C 37 Fragment and Model Wittig Couplings von Ogawa, Anthony K., DeMattei, John A., Scarlato, Gerard R., Tellew, John E., Chong, Lee S., Armstrong, Robert W.

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Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof von Sengupta, Dipanjan, Buzard, Daniel J, Johannsen, Stephen R, Gharbaoui, Tawfik, Martinelli, Michael John, Krishnan, Ashwin M, Ma, You-An, Kuhlman, Young Mi, Montalban, Antonio Garrido, DeMattei, John A, Sato, Suzanne Michiko

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