A defined structural unit enables de novo design of small-molecule-binding proteins von Polizzi, Nicholas F, DeGrado, William F

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Signal Transduction in Histidine Kinases: Insights from New Structures von Bhate, Manasi P., Molnar, Kathleen S., Goulian, Mark, DeGrado, William F.

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The Role of Hydrophobicity in the Antimicrobial and Hemolytic Activities of Polymethacrylate Derivatives von Kuroda, Kenichi, Caputo, Gregory A., DeGrado, William F.

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Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity von Schnaider, Lee, Brahmachari, Sayanti, Schmidt, Nathan W., Mensa, Bruk, Shaham-Niv, Shira, Bychenko, Darya, Adler-Abramovich, Lihi, Shimon, Linda J. W., Kolusheva, Sofiya, DeGrado, William F., Gazit, Ehud

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Structural basis for proton conduction and inhibition by the influenza M2 protein von Hong, Mei, DeGrado, William F.

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Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16 von Mensa, Bruk, Howell, Gabriella L, Scott, Richard, DeGrado, William F

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Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters von Thomaston, Jessica L, Polizzi, Nicholas F, Konstantinidi, Athina, Wang, Jun, Kolocouris, Antonios, DeGrado, William F

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Salt bridges: Geometrically specific, designable interactions von Donald, Jason E., Kulp, Daniel W., DeGrado, William F.

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Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers von Schmidt-Rohr, Klaus, Wang, Jun, Hong, Mei, DeGrado, William F, Cady, Sarah D, Soto, Cinque S

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De novo design of a transmembrane Zn2+-transporting four-helix bundle von Joh, Nathan H., Wang, Tuo, Bhate, Manasi P., Acharya, Rudresh, Wu, Yibing, Grabe, Michael, Hong, Mei, Grigoryan, Gevorg, DeGrado, William F.

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De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications von Tew, Gregory N, Scott, Richard W, Klein, Michael L, DeGrado, William F

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Packing of apolar side chains enables accurate design of highly stable membrane proteins von Mravic, Marco, Thomaston, Jessica L., Tucker, Maxwell, Solomon, Paige E., Liu, Lijun, DeGrado, William F.

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Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics von Watkins, Laura C, DeGrado, William F, Voth, Gregory A

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Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments von Merz, Gregory E., Chalkley, Matthew J., Tan, Sophia K., Tse, Eric, Lee, Joanne, Prusiner, Stanley B., Paras, Nick A., DeGrado, William F., Southworth, Daniel R.

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Amphiphilic Polymethacrylate Derivatives as Antimicrobial Agents von Kuroda, Kenichi, DeGrado, William F

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Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry von Yang, Bing, Wu, Haifan, Schnier, Paul D., Liu, Yansheng, Liu, Jun, Wang, Nanxi, DeGrado, William F., Wang, Lei

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Cys-Scanning Disulfide Crosslinking and Bayesian Modeling Probe the Transmembrane Signaling Mechanism of the Histidine Kinase, PhoQ von Molnar, Kathleen S., Bonomi, Massimiliano, Pellarin, Riccardo, Clinthorne, Graham D., Gonzalez, Gabriel, Goldberg, Shalom D., Goulian, Mark, Sali, Andrej, DeGrado, William F.

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Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins von Yang, Bing, Wang, Nanxi, Schnier, Paul D, Zheng, Feng, Zhu, He, Polizzi, Nicholas F, Ittuveetil, Avinash, Saikam, Varma, DeGrado, William F, Wang, Qian, Wang, Peng G, Wang, Lei

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Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus von Wang, Jun, Wu, Yibing, Ma, Chunlong, Fiorin, Giacomo, Wang, Jizhou, Pinto, Lawrence H., Lamb, Robert A., Klein, Michael L., DeGrado, William F.

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Allosteric cooperation in a de novo-designed two-domain protein von Pirro, Fabio, Schmidt, Nathan, Lincoff, James, Widel, Zachary X., Polizzi, Nicholas F., Liu, Lijun, Therien, Michael J., Grabe, Michael, Chino, Marco, Lombardi, Angela, DeGrado, William F.

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