Herpes simplex virus type 1 inflammasome activation in proinflammatory human macrophages is dependent on NLRP3, ASC, and caspase-1 von Karaba, Andrew H, Figueroa, Alexis, Massaccesi, Guido, Botto, Sara, DeFilippis, Victor R, Cox, Andrea L

Volltext

Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms von Verweij, Marieke C, Wellish, Mary, Whitmer, Travis, Malouli, Daniel, Lapel, Martin, Jonjić, Stipan, Haas, Juergen G, DeFilippis, Victor R, Mahalingam, Ravi, Früh, Klaus

Volltext

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses von Sali, Tina M, Pryke, Kara M, Abraham, Jinu, Liu, Andrew, Archer, Iris, Broeckel, Rebecca, Staverosky, Julia A, Smith, Jessica L, Al-Shammari, Ahmed, Amsler, Lisi, Sheridan, Kayla, Nilsen, Aaron, Streblow, Daniel N, DeFilippis, Victor R

Volltext

The Tiers and Dimensions of Evasion of the Type I Interferon Response by Human Cytomegalovirus von Amsler, Lisi, Verweij, Marieke C., DeFilippis, Victor R.

Volltext

Development of a next-generation chikungunya virus vaccine based on the HydroVax platform von Slifka, Dawn K, Raué, Hans-Peter, Weber, Whitney C, Andoh, Takeshi F, Kreklywich, Craig N, DeFilippis, Victor R, Streblow, Daniel N, Slifka, Mark K, Amanna, Ian J

Volltext

Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1 von DEFILIPPIS, Victor R, ALVARADO, David, SALI, Tina, ROTHENBURG, Stefan, FRÜH, Klaus

Volltext

Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunity von Messaoudi, Ilhem, Vomaske, Jennifer, Totonchy, Thomas, Kreklywich, Craig N, Haberthur, Kristen, Springgay, Laura, Brien, James D, Diamond, Michael S, Defilippis, Victor R, Streblow, Daniel N

Volltext

Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists von Chiang, Cindy, Beljanski, Vladimir, Yin, Kevin, Olagnier, David, Ben Yebdri, Fethia, Steel, Courtney, Goulet, Marie-Line, DeFilippis, Victor R, Streblow, Daniel N, Haddad, Elias K, Trautmann, Lydie, Ross, Ted, Lin, Rongtuan, Hiscott, John

Volltext

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology von Hirsch, Alec J., Roberts, Victoria H. J., Grigsby, Peta L., Haese, Nicole, Schabel, Matthias C., Wang, Xiaojie, Lo, Jamie O., Liu, Zheng, Kroenke, Christopher D., Smith, Jessica L., Kelleher, Meredith, Broeckel, Rebecca, Kreklywich, Craig N., Parkins, Christopher J., Denton, Michael, Smith, Patricia, DeFilippis, Victor, Messer, William, Nelson, Jay A., Hennebold, Jon D., Grafe, Marjorie, Colgin, Lois, Lewis, Anne, Ducore, Rebecca, Swanson, Tonya, Legasse, Alfred W., Axthelm, Michael K., MacAllister, Rhonda, Moses, Ashlee V., Morgan, Terry K., Frias, Antonio E., Streblow, Daniel N.

Volltext

Chikungunya Virus Induces IPS-1-Dependent Innate Immune Activation and Protein Kinase R-Independent Translational Shutoff von WHITE, Laura K, SALI, Tina, ALVARADO, David, GATTI, Evelina, PIERRE, Philippe, STREBLOW, Daniel, DEFILIPPIS, Victor R

Volltext

Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues von Hirsch, Alec J, Smith, Jessica L, Haese, Nicole N, Broeckel, Rebecca M, Parkins, Christopher J, Kreklywich, Craig, DeFilippis, Victor R, Denton, Michael, Smith, Patricia P, Messer, William B, Colgin, Lois M A, Ducore, Rebecca M, Grigsby, Peta L, Hennebold, Jon D, Swanson, Tonya, Legasse, Alfred W, Axthelm, Michael K, MacAllister, Rhonda, Wiley, Clayton A, Nelson, Jay A, Streblow, Daniel N

Volltext

Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway von Landais, Igor, Pelton, Chantel, Streblow, Daniel, DeFilippis, Victor, McWeeney, Shannon, Nelson, Jay A

Volltext

Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferons von Pham, Andrew H, Mitchell, Jennifer, Botto, Sara, Pryke, Kara M, DeFilippis, Victor R, Hancock, Meaghan H

Volltext

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AI... von Botto, Sara, Abraham, Jinu, Mizuno, Nobuyo, Pryke, Kara, Gall, Bryan, Landais, Igor, Streblow, Daniel N, Fruh, Klaus J, DeFilippis, Victor R

Volltext

The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection von Murphy Schafer, Ashleigh R, Smith, Jessica L, Pryke, Kara M, DeFilippis, Victor R, Hirsch, Alec J

Volltext

Bystander monocytic cells drive infection-independent NLRP3 inflammasome response to SARS-CoV-2 von Hsieh, Leon L, Looney, Monika, Figueroa, Alexis, Massaccesi, Guido, Stavrakis, Georgia, Anaya, Eduardo U, D'Alessio, Franco R, Ordonez, Alvaro A, Pekosz, Andrew S, DeFilippis, Victor R, Karakousis, Petros C, Karaba, Andrew H, Cox, Andrea L

Volltext

Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus von Uhrlaub, Jennifer L, Pulko, Vesna, DeFilippis, Victor R, Broeckel, Rebecca, Streblow, Daniel N, Coleman, Gary D, Park, Byung S, Lindo, John F, Vickers, Ivan, Anzinger, Joshua J, Nikolich-Žugich, Janko

Volltext

Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs von Broeckel, Rebecca, Sarkar, Sanjay, May, Nicholas A, Totonchy, Jennifer, Kreklywich, Craig N, Smith, Patricia, Graves, Lee, DeFilippis, Victor R, Heise, Mark T, Morrison, Thomas E, Moorman, Nathaniel, Streblow, Daniel N

Volltext

Viral hijacking of the host ubiquitin system to evade interferon responses von Viswanathan, Kasinath, Früh, Klaus, DeFilippis, Victor

Volltext

The ORF61 Protein Encoded by Simian Varicella Virus and Varicella-Zoster Virus Inhibits NF-κB Signaling by Interfering with IκBα Degradation von Whitmer, Travis, Malouli, Daniel, Uebelhoer, Luke S, DeFilippis, Victor R, Früh, Klaus, Verweij, Marieke C

Volltext