Mechanistic Study on the Use of the l‑Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodr... von Puris, Elena, Gynther, Mikko, de Lange, Elizabeth C.M, Auriola, Seppo, Hammarlund-Udenaes, Margareta, Huttunen, Kristiina M, Loryan, Irena

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In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant von de Witte, Wilhelmus E.A, Danhof, Meindert, van der Graaf, Piet H, de Lange, Elizabeth C.M

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Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model von Puris, Elena, Auriola, Seppo, Petralla, Sabrina, Hartman, Robin, Gynther, Mikko, de Lange, Elizabeth C.M., Fricker, Gert

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The 3D Brain Unit Network Model to Study Spatial Brain Drug Exposure under Healthy and Pathological Conditions von Vendel, Esmée, Rottschäfer, Vivi, de Lange, Elizabeth C.M.

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Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research von Danhof, Meindert, de Lange, Elizabeth C.M, Della Pasqua, Oscar E, Ploeger, Bart A, Voskuyl, Rob A

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Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals von Qin, Tian, Prins, Samantha, Groeneveld, Geert Jan, Van Westen, Gerard, de Vries, Helga E, Wong, Yin Cheong, Bischoff, Luc J M, de Lange, Elizabeth C M

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Effects of daily L-dopa administration on learning and brain structure in older adults undergoing cognitive training: a randomised clinical trial von Lebedev, Alexander V., Nilsson, Jonna, Lindström, Joanna, Fredborg, William, Akenine, Ulrika, Hillilä, Carolina, Andersen, Pia, Spulber, Gabriela, de Lange, Elizabeth C. M., van den Berg, Dirk-Jan, Kivipelto, Miia, Lövdén, Martin

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Prediction of methotrexate CNS distribution in different species – Influence of disease conditions von Westerhout, Joost, van den Berg, Dirk-Jan, Hartman, Robin, Danhof, Meindert, de Lange, Elizabeth C.M.

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High-performance liquid chromatography of nalbuphine, butorphanol and morphine in blood and brain microdialysate samples: Application to pharmacokinetic/pharmacodynamic studies in... von Groenendaal, Dorien, Blom-Roosemalen, Margret C.M., Danhof, Meindert, Lange, Elizabeth C.M. de

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P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice von Sills, Graeme J., Kwan, Patrick, Butler, Elaine, de Lange, Elizabeth C.M., van den Berg, Dirk-Jan, Brodie, Martin J.

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T lymphocytes impair P-glycoprotein function during neuroinflammation von Kooij, Gijs, van Horssen, Jack, de Lange, Elizabeth C.M, Reijerkerk, Arie, van der Pol, Susanne M.A, van het Hof, Bert, Drexhage, Joost, Vennegoor, Anke, Killestein, Joep, Scheffer, George, Oerlemans, Ruud, Scheper, Rik, van der Valk, Paul, Dijkstra, Christine D, de Vries, Helga E

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Methodological issues in microdialysis sampling for pharmacokinetic studies von de Lange, Elizabeth C.M., de Boer, A.G., Breimer, Douwe D.

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Understanding Drug Delivery to the Brain Using Liposome-Based Strategies: Studies that Provide Mechanistic Insights Are Essential von Juhairiyah, Firda, de Lange, Elizabeth C. M.

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Blood‐Based Biomarkers of Quinpirole Pharmacology: Cluster‐Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain von Brink, Willem J., Hartman, Robin, Berg, Dirk‐Jan, Flik, Gunnar, Gonzalez‐Amoros, Belén, Koopman, Nanda, Elassais‐Schaap, Jeroen, Graaf, Piet Hein, Hankemeier, Thomas, Lange, Elizabeth C.M.

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Imaging Techniques in Alzheimer's Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring von van Oostveen, Wieke M, de Lange, Elizabeth C M

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Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier von Wijnholds, J, deLange, E C, Scheffer, G L, van den Berg, D J, Mol, C A, van der Valk, M, Schinkel, A H, Scheper, R J, Breimer, D D, Borst, P

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Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease von Ravenstijn, Paulien Gm, Drenth, Henk-Jan, O'Neill, Michael J, Danhof, Meindert, de Lange, Elizabeth Cm

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Understanding the Blood‐Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics von Lange, Elizabeth C. M., Hammarlund Udenaes, Margareta

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The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK–PD experiments von Ravenstijn, Paulien G.M., Merlini, Mario, Hameetman, Marjolijn, Murray, Tracey K., Ward, Mark A., Lewis, Hywel, Ball, Gareth, Mottart, Cathy, de Ville de Goyet, Christine, Lemarchand, Thomas, van Belle, Kristel, O'Neill, Michael J., Danhof, Meindert, de Lange, Elizabeth C.M.

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Targeted brain delivery of methotrexate by glutathione PEGylated liposomes: How can the formulation make a difference? von Hu, Yang, Gaillard, Pieter J., de Lange, Elizabeth C.M., Hammarlund-Udenaes, Margareta

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