Status of Metabolomic Measurement for Insights in Alzheimer's Disease Progression-What Is Missing? von Yin, Chunyuan, Harms, Amy C, Hankemeier, Thomas, Kindt, Alida, de Lange, Elizabeth C M

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The implications of target saturation for the use of drug–target residence time von de Witte, Wilhelmus E. A., Danhof, Meindert, van der Graaf, Piet H., de Lange, Elizabeth C. M.

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Revisiting Cerebrospinal Fluid Flow Direction and Rate in Physiologically Based Pharmacokinetic Model von Hirasawa, Makoto, de Lange, Elizabeth C. M

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The need for mathematical modelling of spatial drug distribution within the brain von Vendel, Esmée, Rottschäfer, Vivi, de Lange, Elizabeth C M

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Revisiting atenolol as a low passive permeability marker von Chen, Xiaomei, Slättengren, Tim, de Lange, Elizabeth C M, Smith, David E, Hammarlund-Udenaes, Margareta

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Utility of CSF in translational neuroscience von de Lange, Elizabeth C. M.

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A 3D brain unit model to further improve prediction of local drug distribution within the brain von Vendel, Esmée, Rottschäfer, Vivi, de Lange, Elizabeth C. M

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A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations von Yamamoto, Yumi, Välitalo, Pyry A., van den Berg, Dirk-Jan, Hartman, Robin, van den Brink, Willem, Wong, Yin Cheong, Huntjens, Dymphy R., Proost, Johannes H., Vermeulen, An, Krauwinkel, Walter, Bakshi, Suruchi, Aranzana-Climent, Vincent, Marchand, Sandrine, Dahyot-Fizelier, Claire, Couet, William, Danhof, Meindert, van Hasselt, Johan G. C., de Lange, Elizabeth C. M.

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Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human von Wong, Yin Cheong, Centanni, Maddalena, Lange, Elizabeth C. M.

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Imaging Techniques in Alzheimer's Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring von van Oostveen, Wieke M, de Lange, Elizabeth C M

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Next-generation biomarker discovery in Alzheimer's disease using metabolomics - from animal to human studies von Hurtado, Marina Ollé, Kohler, Isabelle, de Lange, Elizabeth CM

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Mechanism-based pharmacokinetic -pharmacodynamic modeling : Biophase distribution, receptor theory, and dynamical systems analysis von DANHOF, Meindert, DE JONGH, Joost, DE LANGE, Elizabeth C. M, PASQUA, Oscar Della, PLOEGER, Bart A, VOSKUYL, Rob A

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Non‐linear blood–brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix von Budda, Divakar, Gülave, Berfin, Hasselt, J. G. Coen, Lange, Elizabeth C. M.

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The Extension of the LeiCNS-PK3.0 Model in Combination with the “Handshake” Approach to Understand Brain Tumor Pathophysiology von Hirasawa, Makoto, Saleh, Mohammed A. A., de Lange, Elizabeth C. M.

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Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies: Towards Prediction of Nose-to-Brain Transport in Humans von Ruigrok, Mitchel J. R., de Lange, Elizabeth C. M.

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Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations von Yamamoto, Yumi, Danhof, Meindert, de Lange, Elizabeth C. M.

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Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice von Saleh, Mohammed A. A., Gülave, Berfin, Campagne, Olivia, Stewart, Clinton F., Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C. M.

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Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC50 Values in Aging and Alzheimer’s Disease, Using the Physiologically Based LeiCNS-PK3.0 Model von Saleh, Mohammed A. A., Bloemberg, Julia S., Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C. M.

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Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations von Saleh, Mohammed A. A., Loo, Chi Fong, Elassaiss-Schaap, Jeroen, De Lange, Elizabeth C. M.

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Physiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats von Westerhout, Joost, Ploeger, Bart, Smeets, Jean, Danhof, Meindert, de Lange, Elizabeth C. M.

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