Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index von Shen, Wen, De Hoyos, Cheryl L., Migawa, Michael T., Vickers, Timothy A., Sun, Hong, Low, Audrey, Bell, Thomas A., Rahdar, Meghdad, Mukhopadhyay, Swagatam, Hart, Christopher E., Bell, Melanie, Riney, Stan, Murray, Susan F., Greenlee, Sarah, Crooke, Rosanne M., Liang, Xue-hai, Seth, Punit P., Crooke, Stanley T.

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Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides von Ostergaard, Michael E., De Hoyos, Cheryl L., Wan, W. Brad, Shen, Wen, Low, Audrey, Berdeja, Andres, Vasquez, Guillermo, Murray, Susan, Migawa, Michael T., Liang, Xue-hai, Swayze, Eric E., Crooke, Stanley T., Seth, Punit P.

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Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides von Anderson, Brooke A, Freestone, Graeme C, Low, Audrey, De-Hoyos, Cheryl L, III, William J Drury, Østergaard, Michael E, Migawa, Michael T, Fazio, Michael, Wan, W Brad, Berdeja, Andres, Scandalis, Eli, Burel, Sebastien A, Vickers, Timothy A, Crooke, Stanley T, Swayze, Eric E, Liang, Xuehai, Seth, Punit P

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Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes von Liang, Xue-hai, Sun, Hong, Hsu, Chih-Wei, Nichols, Joshua G, Vickers, Timothy A, De Hoyos, Cheryl L, Crooke, Stanley T

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Dynamic nucleoplasmic and nucleolar localization of mammalian RNase H1 in response to RNAP I transcriptional R-loops von Shen, Wen, Sun, Hong, De Hoyos, Cheryl L, Bailey, Jeffrey K, Liang, Xue-Hai, Crooke, Stanley T

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RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery von Lima, Walt F, De Hoyos, Cheryl L, Liang, Xue-hai, Crooke, Stanley T

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Acute hepatotoxicity of 2′ fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins von Shen, Wen, De Hoyos, Cheryl L, Sun, Hong, Vickers, Timothy A, Liang, Xue-hai, Crooke, Stanley T

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Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins von Migawa, Michael T, Shen, Wen, Wan, W Brad, Vasquez, Guillermo, Oestergaard, Michael E, Low, Audrey, De Hoyos, Cheryl L, Gupta, Ruchi, Murray, Susan, Tanowitz, Michael, Bell, Melanie, Nichols, Joshua G, Gaus, Hans, Liang, Xue-Hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P

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Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity von Liang, Xue-hai, Nichols, Joshua G, De Hoyos, Cheryl L, Crooke, Stanley T

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Depletion of NEAT1 lncRNA attenuates nucleolar stress by releasing sequestered P54nrb and PSF to facilitate c-Myc translation von Shen, Wen, Liang, Xue-Hai, Sun, Hong, De Hoyos, Cheryl L, Crooke, Stanley T

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