A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia von Tzelepis, Konstantinos, Koike-Yusa, Hiroko, De Braekeleer, Etienne, Li, Yilong, Metzakopian, Emmanouil, Dovey, Oliver M., Mupo, Annalisa, Grinkevich, Vera, Li, Meng, Mazan, Milena, Gozdecka, Malgorzata, Ohnishi, Shuhei, Cooper, Jonathan, Patel, Miten, McKerrell, Thomas, Chen, Bin, Domingues, Ana Filipa, Gallipoli, Paolo, Teichmann, Sarah, Ponstingl, Hannes, McDermott, Ultan, Saez-Rodriguez, Julio, Huntly, Brian J.P., Iorio, Francesco, Pina, Cristina, Vassiliou, George S., Yusa, Kosuke

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CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs von Coelho, Matthew A., De Braekeleer, Etienne, Firth, Mike, Bista, Michal, Lukasiak, Sebastian, Cuomo, Maria Emanuela, Taylor, Benjamin J. M.

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KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements von Au, Yan Zi, Gu, Muxin, De Braekeleer, Etienne, Gozdecka, Malgorzata, Aspris, Demetrios, Tarumoto, Yusuke, Cooper, Jonathan, Yu, Jason, Ong, Swee Hoe, Chen, Xi, Tzelepis, Konstantinos, Huntly, Brian J. P., Vassiliou, George, Yusa, Kosuke

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PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy von Hsu, Joanne I., Dayaram, Tajhal, Tovy, Ayala, De Braekeleer, Etienne, Jeong, Mira, Wang, Feng, Zhang, Jianhua, Heffernan, Timothy P., Gera, Sonal, Kovacs, Jeffrey J., Marszalek, Joseph R., Bristow, Christopher, Yan, Yuanqing, Garcia-Manero, Guillermo, Kantarjian, Hagop, Vassiliou, George, Futreal, P. Andrew, Donehower, Lawrence A., Takahashi, Koichi, Goodell, Margaret A.

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Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis von Insua‐Rodríguez, Jacob, Pein, Maren, Hongu, Tsunaki, Meier, Jasmin, Descot, Arnaud, Lowy, Camille M, De Braekeleer, Etienne, Sinn, Hans‐Peter, Spaich, Saskia, Sütterlin, Marc, Schneeweiss, Andreas, Oskarsson, Thordur

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Cytogenetic Resources and Information von De Braekeleer, Etienne, Huret, Jean-Loup, Mossafa, Hossain, Dessen, Philippe

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ABL1 fusion genes in hematological malignancies: a review von De Braekeleer, Etienne, Douet-Guilbert, Nathalie, Rowe, David, Bown, Nick, Morel, Frédéric, Berthou, Christian, Férec, Claude, De Braekeleer, Marc

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Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia von Yankova, Eliza, Blackaby, Wesley, Albertella, Mark, Rak, Justyna, De Braekeleer, Etienne, Tsagkogeorga, Georgia, Pilka, Ewa S., Aspris, Demetrios, Leggate, Dan, Hendrick, Alan G., Webster, Natalie A., Andrews, Byron, Fosbeary, Richard, Guest, Patrick, Irigoyen, Nerea, Eleftheriou, Maria, Gozdecka, Malgorzata, Dias, Joao M. L., Bannister, Andrew J., Vick, Binje, Jeremias, Irmela, Vassiliou, George S., Rausch, Oliver, Tzelepis, Konstantinos, Kouzarides, Tony

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RUNX1 Translocations in Malignant Hemopathies von DE BRAEKELEER, Etienne, FEREC, Claude, DE BRAEKELEER, Marc

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METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation von Orellana, Esteban A., Liu, Qi, Yankova, Eliza, Pirouz, Mehdi, De Braekeleer, Etienne, Zhang, Wencai, Lim, Jihoon, Aspris, Demetrios, Sendinc, Erdem, Garyfallos, Dimitrios A., Gu, Muxin, Ali, Raja, Gutierrez, Alejandro, Mikutis, Sigitas, Bernardes, Gonçalo J.L., Fischer, Eric S., Bradley, Allan, Vassiliou, George S., Slack, Frank J., Tzelepis, Konstantinos, Gregory, Richard I.

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ETV6 fusion genes in hematological malignancies: A review von De Braekeleer, Etienne, Douet-Guilbert, Nathalie, Morel, Frédéric, Le Bris, Marie-Josée, Basinko, Audrey, De Braekeleer, Marc

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UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs von Gozdecka, Malgorzata, Meduri, Eshwar, Mazan, Milena, Tzelepis, Konstantinos, Dudek, Monika, Knights, Andrew J., Pardo, Mercedes, Yu, Lu, Choudhary, Jyoti S., Metzakopian, Emmanouil, Iyer, Vivek, Yun, Haiyang, Park, Naomi, Varela, Ignacio, Bautista, Ruben, Collord, Grace, Dovey, Oliver, Garyfallos, Dimitrios A., De Braekeleer, Etienne, Kondo, Saki, Cooper, Jonathan, Göttgens, Berthold, Bullinger, Lars, Northcott, Paul A., Adams, David, Vassiliou, George S., Huntly, Brian J. P.

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A second case of secondary acute myeloblastic leukemia associated with the MLL–KIAA0284 fusion gene von Braekeleer, Etienne De, Ianotto, Jean-Christophe, Douet-Guilbert, Nathalie, Meyer, Claus, Morel, Frédéric, Le Bris, Marie-Josée, Marschalek, Rolf, Berthou, Christian, Férec, Claude, De Braekeleer, Marc

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SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 von Tzelepis, Konstantinos, De Braekeleer, Etienne, Aspris, Demetrios, Barbieri, Isaia, Vijayabaskar, M. S., Liu, Wen-Hsin, Gozdecka, Malgorzata, Metzakopian, Emmanouil, Toop, Hamish D., Dudek, Monika, Robson, Samuel C., Hermida-Prado, Francisco, Yang, Yu Hsuen, Babaei-Jadidi, Roya, Garyfallos, Dimitrios A., Ponstingl, Hannes, Dias, Joao M. L., Gallipoli, Paolo, Seiler, Michael, Buonamici, Silvia, Vick, Binje, Bannister, Andrew J., Rad, Roland, Prinjha, Rab K., Marioni, John C., Huntly, Brian, Batson, Jennifer, Morris, Jonathan C., Pina, Cristina, Bradley, Allan, Jeremias, Irmela, Bates, David O., Yusa, Kosuke, Kouzarides, Tony, Vassiliou, George S.

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Abstract 608: The MPS1 inhibitor S81694 is active in acute myeloid leukemia (AML) von Kaci, Anna, Adicéam, Emilie, De Braekeleer, Etienne, Garrido, Marine, Berrou, Jeannig, Dupont, Mélanie, Djamai, Hanane, Eclache, Virginie, André, Baruchel, Gardin, Claude, Dombret, Hervé, Burbridge, Mike, Braun, Thorsten

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Publisher Correction: UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs von Gozdecka, Malgorzata, Meduri, Eshwar, Mazan, Milena, Tzelepis, Konstantinos, Dudek, Monika, Knights, Andrew J., Pardo, Mercedes, Yu, Lu, Choudhary, Jyoti S., Metzakopian, Emmanouil, Iyer, Vivek, Yun, Haiyang, Park, Naomi, Varela, Ignacio, Bautista, Ruben, Collord, Grace, Dovey, Oliver, Garyfallos, Dimitrios A., De Braekeleer, Etienne, Kondo, Saki, Cooper, Jonathan, Göttgens, Berthold, Bullinger, Lars, Northcott, Paul A., Adams, David, Vassiliou, George S., Huntly, Brian J. P.

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The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL von De Braekeleer, Etienne, Hsu, Joanne, Hervieu, Celine, Tzelepis, Konstantinos, Indraccolo, Stefano, Warren, Alan J., Jeremias, Irmela, Antoran, David Fernandez, Jones, Phil H, Goodell, Margaret A., Vassiliou, George S.

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Pharmacological Inhibition of the RNA m6a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia von Tzelepis, Konstantinos, De Braekeleer, Etienne, Yankova, Eliza, Rak, Justyna, Aspris, Demetrios, Domingues, Ana Filipa, Fosbeary, Richard, Hendrick, Alan, Leggate, Dan, Ofir-Rosenfeld, Yaara, Sapetschnig, Alexandra, Pina, Cristina, Albertella, Mark, Blackaby, Wesley, Rausch, Oliver, Vassiliou, George S., Kouzarides, Tony

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Setbp1 Overexpression Acts in the Place of Class-Defining Somatic Mutations to Drive Mouse and Human FLT3-ITD-Mutant AMLs von Pacharne, Suruchi, Dovey, Oliver M., Cooper, Jonathan L, Gu, Muxin, Baskar, Vijay, Friedrich, Mathias J, Gozdecka, Malgorzata, Rajan, Sandeep S, De Braekeleer, Etienne, Barenboim, Maxim, Collord, Grace, Postingl, Hannes, Bautista, Ruben, Mazan, Milena, Rad, Roland, Tzelepis, Konstantinos, Wright, Penny, Vassiliou, George S.

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3q26/EVI1 rearrangements in myeloid hemopathies: a cytogenetic review von De Braekeleer, Marc, Le Bris, Marie-Josée, De Braekeleer, Etienne, Basinko, Audrey, Morel, Frédéric, Douet-Guilbert, Nathalie

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