The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia von Erdem, Ayşegül, Marin, Silvia, Pereira-Martins, Diego A., Cortés, Roldán, Cunningham, Alan, Pruis, Maurien G., de Boer, Bauke, van den Heuvel, Fiona A. J., Geugien, Marjan, Wierenga, Albertus T. J., Brouwers-Vos, Annet Z., Rego, Eduardo M., Huls, Gerwin, Cascante, Marta, Schuringa, Jan Jacob

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Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock von Azkanaz, Maria, Rodríguez López, Aida, de Boer, Bauke, Huiting, Wouter, Angrand, Pierre-Olivier, Vellenga, Edo, Kampinga, Harm H, Bergink, Steven, Martens, Joost Ha, Schuringa, Jan Jacob, van den Boom, Vincent

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Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment von Priller, Josef, Flügel, Alexander, Wehner, Tim, Boentert, Matthias, Haas, Carola A, Prinz, Marco, Fernández-Klett, Francisco, Prass, Konstantin, Bechmann, Ingo, de Boer, Bauke A, Frotscher, Michael, Kreutzberg, Georg W, Persons, Derek A, Dirnagl, Ulrich

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The IL1-IL1RAP axis plays an important role in the inflammatory leukemic niche that favors acute myeloid leukemia proliferation over normal hematopoiesis von De Boer, Bauke, Sheveleva, Sofia, Apelt, Katja, Vellenga, Edo, Mulder, Andre B., Huls, Gerwin, Schuringa, Jan Jacob

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Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones von de Boer, Bauke, Prick, Janine, Pruis, Maurien G., Keane, Peter, Imperato, Maria Rosaria, Jaques, Jennifer, Brouwers-Vos, Annet Z., Hogeling, Shanna M., Woolthuis, Carolien M., Nijk, Marije T., Diepstra, Arjan, Wandinger, Sebastian, Versele, Matthias, Attar, Ricardo M., Cockerill, Peter N., Huls, Gerwin, Vellenga, Edo, Mulder, André B., Bonifer, Constanze, Schuringa, Jan Jacob

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Inconsistency in ferritin reference intervals across laboratories: a major concern for clinical decision making von Kurstjens, Steef, van Dam, Andrea D, Oortwijn, Ellis, den Elzen, Wendy P J, Candido, Firmin, Kusters, Ron, Schipper, Anoeska, Kortmann, Yvo F C, Herings, Ron M C, Kok, Maarten, Krabbe, Johannes, de Boer, Bauke A, de Jong, Anne-Margreet, Frasa, Marieke A M

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Establishing human leukemia xenograft mouse models by implanting human bone marrow–like scaffold-based niches von Antonelli, Antonella, Noort, Willy A., Jaques, Jenny, de Boer, Bauke, de Jong-Korlaar, Regina, Brouwers-Vos, Annet Z., Lubbers-Aalders, Linda, van Velzen, Jeroen F., Bloem, Andries C., Yuan, Huipin, de Bruijn, Joost D., Ossenkoppele, Gert J., Martens, Anton C.M., Vellenga, Edo, Groen, Richard W.J., Schuringa, Jan Jacob

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3027 – TET2 AND WT1 MUTATIONS ACCELERATE CEBPA P30 LEUKEMIA DEVELOPMENT von De Boer, Bauke, Schovsbo, Sofie, Schuster, Mikkel, Mikkelsen, Nanna, Aragon-Fernandez, Pedro, Schoof, Erwin, Theilgaard-Mönch, Kim, Bak, Rasmus, Porse, Bo

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3035 – THE IL1-IL1RAP AXIS PLAYS AN IMPORTANT ROLE IN THE INFLAMMATORY LEUKEMIC NICHE THAT FAVORS ACUTE MYELOID LEUKEMIA CELL PROLIFERATION OVER NORMAL HEMATOPOIESIS von Sheveleva, Sofia, de Boer, Bauke, Apelt, Katja, Huls, Gerwin, Mulder, Andre, Vellenga, Edo, Schuringa, Jan Jacob

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3065 – CRISPR MODELING OF ACUTE MYELOID LEUKEMIA MUTATIONS IN PRIMARY HEMATOPOIETIC STEM CELLS TO STUDY (PRE-)LEUKEMIA DEVELOPMENT von de Boer, Bauke, Schovsbo, Sofie, Furtwängler, Benjamin, Schuster, Mikkel, Mikkelsen, Nanna S, Schoof, Erwin, Theilgaard-Mönch, Kim, Bak, Rasmus, Porse, Bo

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The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes von Trempenau, Mette Louise, Schuster, Mikkel Bruhn, Pundhir, Sachin, Pereira, Mafalda Araujo, Kalvisa, Adrija, Tapia, Marta, Su, Jinyu, Ge, Ying, de Boer, Bauke, Balhuizen, Alexander, Bagger, Frederik Otzen, Shliaha, Pavel, Sroczynska, Patrycja, Walfridsson, Julian, Grønbæk, Kirsten, Theilgaard-Mönch, Kim, Jensen, Ole N., Helin, Kristian, Porse, Bo T.

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Genetically engineered mesenchymal stromal cells produce IL-3 and TPO to further improve human scaffold-based xenograft models von Carretta, M, de Boer, B, Jaques, J, Antonelli, A, Horton, S.J, Yuan, H, de Bruijn, J.D, Groen, R.W.J, Vellenga, E, Schuringa, Jan Jacob

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Stress-induced epigenetic remodeling of polycomb target genes von Schuringa, Jan Jacob, de Boer, Bauke, Bouwers-Vos, Annet, Vellenga, Edo, Kampinga, Harrie, Bergink, Steven, van den Boom, Vincent

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The role of polycomb group proteins and KDM2B in leukemia von van den Boom, Vincent, de Boer, Bauke, Elliott, Maia, Angrand, Pierre-Olivier, Vellenga, Edo, Schuringa, Jan Jacob

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Establishing Human Niche Xenograft Models for Myeloid and Lymphoid Leukemia Driven By MLL-AF9 von Carretta, Marco, Jaques, Jennifer, de Boer, Bauke, Yuan, Huipin, Martens, Anton C., Vellenga, Edo, Groen, Richard W.J., Schuringa, Jan Jacob

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Identification of leukemia enriched plasma membrane proteins allows prospective isolation and analysis of distinct subclones providing new opportunities for diagnosis and targeting... von de Boer, Bauke, Brouwers-Vos, Annet, Jaques, Jennifer, Pruis, Maurien, Casneuf, Tineke, Wandinger, Sebastian, Vellenga, Edo, Versele, Matthias, Mulder, André, Schuringa, Jan Jacob

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Dynamics in N-terminal pro-brain natriuretic peptide concentration in patients with non–ST-elevation acute coronary syndrome von Riezebos, Robert K., Ronner, Eelko, de Boer, Bauke A., Slaats, Ed H., Tijssen, Jan G.P., Laarman, Gert-Jan

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CombiFlow: combinatorial AML-specific plasma membrane expression profiles allow longitudinal tracking of clones von Houtsma, Roos, van der Meer, Nisha K., Meijer, Kees, Morsink, Linde M., Hogeling, Shanna M., Woolthuis, Carolien M., Ammatuna, Emanuele, Nijk, Marije T., de Boer, Bauke, Huls, Gerwin, Mulder, André B., Schuringa, Jan Jacob

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Inflamed kidneys of NZB / W mice are a major site for the homeostasis of plasma cells von Cassese, Giuliana, Lindenau, Steffi, de Boer, Bauke, Arce, Sergio, Hauser, Anja, Riemekasten, Gabriela, Berek, Claudia, Hiepe, Falk, Krenn, Veit, Radbruch, Andreas, Manz, Rudolf A.

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CXCR5‐deficient mice develop functional germinal centers in the splenic T cell zone von Voigt, Ileana, Camacho, Stephanie A., de Boer, Bauke A., Lipp, Martin, Förster, Reinhold, Berek, Claudia

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