Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance von Zhou, Meiyi, Shao, Jing, Wu, Cheng-Yang, Shu, Le, Dong, Weibing, Liu, Yunxia, Chen, Mengping, Wynn, R Max, Wang, Jiqiu, Wang, Ji, Gui, Wen-Jun, Qi, Xiangbing, Lusis, Aldons J, Li, Zhaoping, Wang, Weiqing, Ning, Guang, Yang, Xia, Chuang, David T, Wang, Yibin, Sun, Haipeng

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Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure von Sun, Haipeng, Olson, Kristine C, Gao, Chen, Prosdocimo, Domenick A, Zhou, Meiyi, Wang, Zhihua, Jeyaraj, Darwin, Youn, Ji-Youn, Ren, Shuxun, Liu, Yunxia, Rau, Christoph D, Shah, Svati, Ilkayeva, Olga, Gui, Wen-Jun, William, Noelle S, Wynn, R Max, Newgard, Christopher B, Cai, Hua, Xiao, Xinshu, Chuang, David T, Schulze, Paul Christian, Lynch, Christopher, Jain, Mukesh K, Wang, Yibin

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The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase von White, Phillip J., McGarrah, Robert W., Grimsrud, Paul A., Tso, Shih-Chia, Yang, Wen-Hsuan, Haldeman, Jonathan M., Grenier-Larouche, Thomas, An, Jie, Lapworth, Amanda L., Astapova, Inna, Hannou, Sarah A., George, Tabitha, Arlotto, Michelle, Olson, Lyra B., Lai, Michelle, Zhang, Guo-Fang, Ilkayeva, Olga, Herman, Mark A., Wynn, R. Max, Chuang, David T., Newgard, Christopher B.

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Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol von Kato, Masato, Li, Jun, Chuang, Jacinta L., Chuang, David T.

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Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket von Tso, Shih-Chia, Qi, Xiangbing, Gui, Wen-Jun, Wu, Cheng-Yang, Chuang, Jacinta L., Wernstedt-Asterholm, Ingrid, Morlock, Lorraine K., Owens, Kyle R., Scherer, Philipp E., Williams, Noelle S., Tambar, Uttam K., Wynn, R. Max, Chuang, David T.

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Therapeutic Effect of Targeting Branched-Chain Amino Acid Catabolic Flux in Pressure-Overload Induced Heart Failure von Chen, Mengping, Gao, Chen, Yu, Jiayu, Ren, Shuxun, Wang, Menglong, Wynn, R Max, Chuang, David T, Wang, Yibin, Sun, Haipeng

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De Novo Backbone Trace of GroEL from Single Particle Electron Cryomicroscopy von Ludtke, Steven J., Baker, Matthew L., Chen, Dong-Hua, Song, Jiu-Li, Chuang, David T., Chiu, Wah

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Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase von Tso, Shih-Chia, Qi, Xiangbing, Gui, Wen-Jun, Chuang, Jacinta L., Morlock, Lorraine K., Wallace, Amy L., Ahmed, Kamran, Laxman, Sunil, Campeau, Philippe M., Lee, Brendan H., Hutson, Susan M., Tu, Benjamin P., Williams, Noelle S., Tambar, Uttam K., Wynn, R. Max, Chuang, David T.

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Lessons from Genetic Disorders of Branched-Chain Amino Acid Metabolism von Chuang, David T, Chuang, Jacinta L, Wynn, R. Max

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Subunit and Catalytic Component Stoichiometries of an in Vitro Reconstituted Human Pyruvate Dehydrogenase Complex von Brautigam, Chad A., Wynn, R. Max, Chuang, Jacinta L., Chuang, David T.

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Pivotal Role of the C-terminal DW-motif in Mediating Inhibition of Pyruvate Dehydrogenase Kinase 2 by Dichloroacetate von Li, Jun, Kato, Masato, Chuang, David T.

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Pathogenic mechanisms underlying X-linked Charcot-Marie-tooth neuropathy (CMTX6) in patients with a pyruvate dehydrogenase kinase 3 mutation von Perez-Siles, Gonzalo, Ly, Carolyn, Grant, Adrienne, Drew, Alexander P, Yiu, Eppie M, Ryan, Monique M, Chuang, David T, Tso, Shih-Chia, Nicholson, Garth A, Kennerson, Marina L

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Zinc-Dependent Interaction between JAB1 and Pre-S2 Mutant Large Surface Antigen of Hepatitis B Virus and Its Implications for Viral Hepatocarcinogenesis von Hsu, Jye-Lin, Chuang, Woei-Jer, Su, Ih-Jen, Gui, Wen-Jun, Chang, Yu-Ying, Lee, Yun-Ping, Ai, Yu-Lin, Chuang, David T, Huang, Wenya

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An Expanded Conformation of Single-Ring GroEL-GroES Complex Encapsulates an 86 kDa Substrate von Chen, Dong-Hua, Song, Jiu-Li, Chuang, David T., Chiu, Wah, Ludtke, Steven J.

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Simultaneous Steady-state and Dynamic 13C NMR Can Differentiate Alternative Routes of Pyruvate Metabolism in Living Cancer Cells von Yang, Chendong, Harrison, Crystal, Jin, Eunsook S., Chuang, David T., Sherry, A. Dean, Malloy, Craig R., Merritt, Matthew E., DeBerardinis, Ralph J.

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A 11.5 A single particle reconstruction of GroEL using EMAN von Ludtke, S J, Jakana, J, Song, J L, Chuang, D T, Chiu, W

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Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase von Tso, Shih-Chia, Gui, Wen-Jun, Wu, Cheng-Yang, Chuang, Jacinta L., Qi, Xiangbing, Skvorak, Kristen J., Dorko, Kenneth, Wallace, Amy L., Morlock, Lorraine K., Lee, Brendan H., Hutson, Susan M., Strom, Stephen C., Williams, Noelle S., Tambar, Uttam K., Wynn, R.Max, Chuang, David T.

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The intrinsic substrate specificity of the human tyrosine kinome von Yaron-Barir, Tomer M., Joughin, Brian A., Huntsman, Emily M., Kerelsky, Alexander, Cizin, Daniel M., Cohen, Benjamin M., Regev, Amit, Song, Junho, Vasan, Neil, Lin, Ting-Yu, Orozco, Jose M., Schoenherr, Christina, Sagum, Cari, Bedford, Mark T., Wynn, R. Max, Tso, Shih-Chia, Chuang, David T., Li, Lei, Li, Shawn S.-C., Creixell, Pau, Krismer, Konstantin, Takegami, Mina, Lee, Harin, Zhang, Bin, Lu, Jingyi, Cossentino, Ian, Landry, Sean D., Uduman, Mohamed, Blenis, John, Elemento, Olivier, Frame, Margaret C., Hornbeck, Peter V., Cantley, Lewis C., Turk, Benjamin E., Yaffe, Michael B., Johnson, Jared L.

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Structure of Rat BCKD Kinase: Nucleotide-Induced Domain Communication in a Mitochondrial Protein Kinase von Machius, Mischa, Chuang, Jacinta L., Wynn, R. Max, Tomchick, Diana R., Chuang, David T.

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Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors von Tso, Shih-Chia, Lou, Mingliang, Wu, Cheng-Yang, Gui, Wen-Jun, Chuang, Jacinta L, Morlock, Lorraine K, Williams, Noelle S, Wynn, R. Max, Qi, Xiangbing, Chuang, David T

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