Epimeric Face-Selective Oxidations and Diastereodivergent Transannular Oxonium Ion Formation Fragmentations: Computational Modeling and Total Syntheses of 12-Epoxyobtusallene IV, 1... von Clarke, James, Bonney, Karl J, Yaqoob, Muhammad, Solanki, Savade, Rzepa, Henry S, White, Andrew J. P, Millan, David S, Braddock, D. Christopher

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Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space von Alex, Alexander, Millan, David S., Perez, Manuel, Wakenhut, Florian, Whitlock, Gavin A.

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Total synthesis of (+)-phorboxazole A, a potent cytostatic agent from the sponge Phorbas sp von Pattenden, Gerald, González, Miguel A, Little, Paul B, Millan, David S, Plowright, Alleyn T, Tornos, James A, Ye, Tao

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Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Dia... von Swain, Nigel. A, Batchelor, Dave, Beaudoin, Serge, Bechle, Bruce M, Bradley, Paul A, Brown, Alan D, Brown, Bruce, Butcher, Ken J, Butt, Richard P, Chapman, Mark L, Denton, Stephen, Ellis, David, Galan, Sebastien R. G, Gaulier, Steven M, Greener, Ben S, de Groot, Marcel J, Glossop, Mel S, Gurrell, Ian K, Hannam, Jo, Johnson, Matthew S, Lin, Zhixin, Markworth, Christopher J, Marron, Brian E, Millan, David S, Nakagawa, Shoko, Pike, Andy, Printzenhoff, David, Rawson, David J, Ransley, Sarah J, Reister, Steven M, Sasaki, Kosuke, Storer, R. Ian, Stupple, Paul A, West, Christopher W

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Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma von Millan, David S., Ballard, Stephen A., Chunn, Sara, Dybowski, Joseph A., Fulton, Craig K., Glossop, Paul A., Guillabert, Edouard, Hewson, Christopher A., Jones, Rhys M., Lamb, David J., Napier, Carolyn M., Payne-Cook, Toby A., Renery, Emmanuelle R., Selby, Matthew D., Tutt, Michelle F., Yeadon, Michael

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A Biosynthetically-Inspired Synthesis of the Tetrahydrofuran Core of Obtusallenes II and IV von Braddock, D. Christopher, Bhuva, Roshni, Millan, David S, Pérez-Fuertes, Yolanda, Roberts, Craig A, Sheppard, Richard N, Solanki, Savade, Stokes, Elaine S. E, White, Andrew J. P

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Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN) von Martin, Matthew W., Lancia, David R., Li, Hongbin, Schiller, Shawn E.R., Toms, Angela V., Wang, Zhongguo, Bair, Kenneth W., Castro, Jennifer, Fessler, Shawn, Gotur, Deepali, Hubbs, Stephen E., Kauffman, Goss S., Kershaw, Mark, Luke, George P., McKinnon, Crystal, Yao, Lili, Lu, Wei, Millan, David S.

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Design and Synthesis of Inhaled p38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease von Millan, David S, Bunnage, Mark E, Burrows, Jane L, Butcher, Kenneth J, Dodd, Peter G, Evans, Timothy J, Fairman, David A, Hughes, Samantha J, Kilty, Iain C, Lemaitre, Arnaud, Lewthwaite, Russell A, Mahnke, Axel, Mathias, John P, Philip, James, Smith, Robert T, Stefaniak, Mark H, Yeadon, Michael, Phillips, Christopher

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Bromonium Ion Induced Transannular Oxonium Ion Formation−Fragmentation in Model Obtusallene Systems and Structural Reassignment of Obtusallenes V−VII von Braddock, D. Christopher, Millan, David S, Pérez-Fuertes, Yolanda, Pouwer, Rebecca H, Sheppard, Richard N, Solanki, Savade, White, Andrew J. P

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Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains von Millan, David S, Kayser-Bricker, Katherine J, Martin, Matthew W, Talbot, Adam C, Schiller, Shawn E. R, Herbertz, Torsten, Williams, Grace L, Luke, George P, Hubbs, Stephen, Alvarez Morales, Monica A, Cardillo, Daniel, Troccolo, Paul, Mendes, Rachel L, McKinnon, Crystal

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Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Dia... von Swain, Nigel A, Batchelor, Dave, Beaudoin, Serge, Bechle, Bruce M, Bradley, Paul A, Brown, Alan D, Brown, Bruce, Butcher, Ken J, Butt, Richard P, Chapman, Mark L, Denton, Stephen, Ellis, David, Galan, Sebastien R G, Gaulier, Steven M, Greener, Ben S, de Groot, Marcel J, Glossop, Mel S, Gurrell, Ian K, Hannam, Jo, Johnson, Matthew S, Lin, Zhixin, Markworth, Christopher J, Marron, Brian E, Millan, David S, Nakagawa, Shoko, Pike, Andy, Printzenhoff, David, Rawson, David J, Ransley, Sarah J, Reister, Steven M, Sasaki, Kosuke, Storer, R Ian, Stupple, Paul A, West, Christopher W

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Fragment based discovery of a novel and selective PI3 kinase inhibitor von Hughes, Samantha J., Millan, David S., Kilty, Iain C., Lewthwaite, Russell A., Mathias, John P., O’Reilly, Mark A., Pannifer, Andrew, Phelan, Anne, Stühmeier, Frank, Baldock, Darren A., Brown, David G.

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Kilogram-Scale Synthesis of an Inhaled Corticosteroid von Knight, Craig J, Millan, David S, Moses, Ian B, Robin, Aurelie A, Selby, Matthew D

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Abstract 1224: Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers von Centore, Richard C., Soares, Luis M., Vaswani, Rishi G., Ichikawa, Kana, Li, Zhifang, Fan, Hong, Setser, Jeremy, Lahr, David L., Zawadzke, Laura, Chen, Xueying, Barnash, Kimberly D., Muwanguzi, Jordana, Anthony, Neville, Sandoval, Gabriel J., Feldman, Katharine, Adam, Ammar, Huang, David, Schiller, Shawn, Wilson, Kevin, Voigt, Johannes, Hentemann, Martin, Millan, David S., Chan, Ho Man, Bellon, Steven F., Decicco, Carl P., Xu, Lan

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Abstract A058: Investigating the molecular role of BRD9 in synovial sarcoma von Topal, Salih, Dominici, Claudia, Collins, Michael, Lahr, David L, Zhou, Qianhe, Uzan, Flore, Mayhew, David, Adam, Ammar, Garbitt-Amaral, Victoria, Antonakos, Brandon, Mikse, Oliver, Ahmad, Hafiz, Parikh, Salonee, Lin, Mei Yun, Wu, Hsin-Jung, Sandoval, Gabriel, Soares, Luis M. M., Muwanguzi, Jordana, Chen, Huawei, Yang, Zhaoxia, Lowe, Jason T., Netherton, Matt, Zawadzke, Laura, Voigt, Johannes, Huang, Liyue, Ruppel, Sabine, Chan, Ho Man, Kruger, Ryan, Millan, David S., Innis, Scott, Bellon, Steven F.

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FT-1101: A Structurally Distinct Pan-BET Bromodomain Inhibitor with Activity in Preclinical Models of Hematologic Malignancies von Millan, David S, Alvarez Morales, Monica A, Barr, Kenneth J, Cardillo, Daniel, Collis, Alan, Dinsmore, Christopher J, Escobedo, Jaime A, Foley, Kevin P, Herbertz, Torsten, Hubbs, Stephen, Kauffman, Goss S, Kayser-Bricker, Katherine J, Kershaw, Mark T, Luke, George P, Martin, Matthew W, McKinnon, Crystal, Mendes, Rachel L, Muskiewicz, Kristina R, Schiller, Shawn ER, Soulard, Patricia, Talbot, Adam C, Walker, Duncan, Yao, Lili, Williams, Grace L

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ChemInform Abstract: Design and Synthesis of Long Acting Inhaled Corticosteroids for the Treatment of Asthma von Millan, David S., ., et al

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The chemistry of 5-oxodihydroisoxazoles. Part 22.1 The synthesis of 1,3-oxazin-6-ones from N-thioacylisoxazol-5(2H )-ones von Millan, David S., Prager, Rolf H.

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The Synthesis and Activity of Oxazole and Thiazole Analogues of Urocanic Acid von Millan, David S., Prager, Rolf H., Brand, Catherine, Hart, Prue H.

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The dealkylation of tertiary aliphatic amines with phenyl chlorothionoformate von Millan, David S., Prager, Rolf H.

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