Mind the gap: Models in multiple species needed for therapeutic development in Huntington's disease von Howland, David S., Munoz-Sanjuan, Ignacio

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Focal Loss of the Glutamate Transporter EAAT2 in a Transgenic Rat Model of SOD1 Mutant-Mediated Amyotrophic Lateral Sclerosis (ALS) von Howland, David S., Liu, Jian, She, Yijin, Goad, Beth, Maragakis, Nicholas J., Kim, Benjamin, Erickson, Jamie, Kulik, John, DeVito, Lisa, Psaltis, George, DeGennaro, Louis J., Cleveland, Don W., Rothstein, Jeffrey D.

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Disruption of Dynein/Dynactin Inhibits Axonal Transport in Motor Neurons Causing Late-Onset Progressive Degeneration von LaMonte, Bernadette H, Wallace, Karen E, Holloway, Beth A, Shelly, Spencer S, Ascaño, Jennifer, Tokito, Mariko, Van Winkle, Thomas, Howland, David S, Holzbaur, Erika L.F

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Impaired Spinal Cord Glutamate Transport Capacity and Reduced Sensitivity to Riluzole in a Transgenic Superoxide Dismutase Mutant Rat Model of Amyotrophic Lateral Sclerosis von Dunlop, John, Beal McIlvain, H, She, Yijin, Howland, David S

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Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis von Holzbaur, Erika L.F., Howland, David S., Weber, Nicholas, Wallace, Karen, She, Yijin, Kwak, Seung, Tchistiakova, Lioudmilla A., Murphy, Erin, Hinson, Joseph, Karim, Riyez, Tan, Xiang Yang, Kelley, Pamela, McGill, Kevin C., Williams, Gareth, Hobbs, Carl, Doherty, Patrick, Zaleska, Margaret M., Pangalos, Menelas N., Walsh, Frank S.

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A transgenic rat model of Alzheimer's disease with extracellular Aβ deposition von Flood, Dorothy G, Lin, Yin-Guo, Lang, Diane M, Trusko, Stephen P, Hirsch, James D, Savage, Mary J, Scott, Richard W, Howland, David S

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Mitochondrial Metabolism in a Large-Animal Model of Huntington Disease: The Hunt for Biomarkers in the Spermatozoa of Presymptomatic Minipigs von Krizova, Jana, Stufkova, Hana, Rodinova, Marie, Macakova, Monika, Bohuslavova, Bozena, Vidinska, Daniela, Klima, Jiri, Ellederova, Zdenka, Pavlok, Antonin, Howland, David S., Zeman, Jiri, Motlik, Jan, Hansikova, Hana

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Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars von Macakova, Monika, Bohuslavova, Bozena, Vochozkova, Petra, Pavlok, Antonin, Sedlackova, Miroslava, Vidinska, Daniela, Vochyanova, Klara, Liskova, Irena, Valekova, Ivona, Baxa, Monika, Ellederova, Zdenka, Klima, Jiri, Juhas, Stefan, Juhasova, Jana, Klouckova, Jana, Haluzik, Martin, Klempir, Jiri, Hansikova, Hana, Spacilova, Jana, Collins, Ryan, Blumenthal, Ian, Talkowski, Michael, Gusella, James F., Howland, David S., DiFiglia, Marian, Motlik, Jan

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Turnover of Amyloid beta -Protein in Mouse Brain and Acute Reduction of Its Level by Phorbol Ester von Savage, Mary J, Trusko, Stephen P, Howland, David S, Pinsker, Leonard R, Mistretta, Suzanne, Reaume, Andrew G, Greenberg, Barry D, Siman, Robert, Scott, Richard W

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Inflammatory mediators and growth factors in the spinal cord of G93A SOD1 rats von Xie, Yiheng, Weydt, Patrick, Howland, David S, Kliot, Michel, Möller, Thomas

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Ablation of central nervous system progenitor cells in transgenic rats using bacterial nitroreductase system von Kwak, Seung P., Malberg, Jessica E., Howland, David S., Cheng, Ke-Yi, Su, Jianying, She, Yin, Fennell, Myles, Ghavami, Afshin

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Disruption of ShcA signaling halts cell proliferation — characterization of ShcC residues that influence signaling pathways using yeast von Heinrich, Julia N., Kwak, Seung P., Howland, David S., Chen, Jin, Sturner, Stephen, Sullivan, Kelly, Lipinski, Kerri, Cheng, Ke-Yi, She, Yijin, Lo, Frederick, Ghavami, Afshin

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Alterations in 5-HT2A receptor signaling in male and female transgenic rats over-expressing either Gq or RGS-insensitive Gq protein von Shi, Ju, Damjanoska, Katerina J, Zemaitaitis, Bozena, Garcia, Francisca, Carrasco, Gonzalo, Sullivan, Nicole R, She, Yijin, Young, Kathleen H, Battaglia, George, Van De kar, Louis D, Howland, David S, Muma, Nancy A

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Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol von Howland, D S, Trusko, S P, Savage, M J, Reaume, A G, Lang, D M, Hirsch, J D, Maeda, N, Siman, R, Greenberg, B D, Scott, R W, Flood, D G

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Inflammatory mediators and growth factors in the spinal cord of G93A SODI rats von YIHENG XIE, WEYDT, Patrick, HOWLAND, David S, KLIOT, Michel, MÖLLER, Thomas

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A transgenic rat model of Alzheimer's disease with extracellular Ab deposition von Flood, Dorothy G, Lin, Yin-Guo, Lang, Diane M, Trusko, Stephen P, Hirsch, James D, Savage, Mary J, Scott, Richard W, Howland, David S

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Enhanced Amyloidogenic Processing of the β-Amyloid Precursor Protein in Gene-targeted Mice Bearing the Swedish Familial Alzheimer's Disease Mutations and a “Humanized” Aβ Sequence... von Reaume, Andrew G., Howland, David S., Trusko, Stephen P., Savage, Mary J., Lang, Diane M., Greenberg, Barry D., Siman, Robert, Scott, Richard W.

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Functionally distinct isoforms of dynactin are expressed in human neurons von Tokito, M K, Howland, D S, Lee, V M, Holzbaur, E L

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Alterations in 5-HT sub(2A) receptor signaling in male and female transgenic rats over-expressing either Gq or RGS-insensitive Gq protein von Shi, Ju, Damjanoska, Katerina J, Zemaitaitis, Bozena W, Garcia, Francisca, Carrasco, Gonzalo, Sullivan, Nicole R, She, Yijin, Young, Kathleen H, Battaglia, George, Van de Kar, Louis D, Howland, David S, Muma, Nancy A

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Alterations in 5-HT 2A receptor signaling in male and female transgenic rats over-expressing either Gq or RGS-insensitive Gq protein von Shi, Ju, Damjanoska, Katerina J., Zemaitaitis, Bozena W., Garcia, Francisca, Carrasco, Gonzalo, Sullivan, Nicole R., She, Yijin, Young, Kathleen H., Battaglia, George, Van De Kar, Louis D., Howland, David S., Muma, Nancy A.

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