Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo von Guendisch, Ulf, Weiss, Jessica, Ecoeur, Florence, Riker, Julia Christina, Kaupmann, Klemens, Kallen, Joerg, Hintermann, Samuel, Orain, David, Dawson, Janet, Billich, Andreas, Guntermann, Christine

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Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin R... von Ecoeur, Florence, Weiss, Jessica, Kaupmann, Klemens, Hintermann, Samuel, Orain, David, Guntermann, Christine

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Linkers and Cleavage Strategies in Solid-Phase Organic Synthesis and Combinatorial Chemistry von Guillier, Fabrice, Orain, David, Bradley, Mark

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Design and Synthesis of Selurampanel, a Novel Orally Active and Competitive AMPA Receptor Antagonist von Orain, David, Tasdelen, Engin, Haessig, Samuel, Koller, Manuel, Picard, Anne, Dubois, Celine, Lingenhoehl, Kurt, Desrayaud, Sandrine, Floersheim, Phillip, Carcache, David, Urwyler, Stephan, Kallen, Joerg, Mattes, Henri

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Fear-reducing effects of intra-amygdala neuropeptide Y infusion in animal models of conditioned fear: an NPY Y1 receptor independent effect von Fendt, Markus, Bürki, Hugo, Imobersteg, Stefan, Lingenhöhl, Kurt, McAllister, Kevin H., Orain, David, Uzunov, Doncho P., Chaperon, Frederique

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Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations von Guntermann, Christine, Piaia, Alessandro, Hamel, Marie-Laure, Theil, Diethilde, Rubic-Schneider, Tina, Del Rio-Espinola, Alberto, Dong, Linda, Billich, Andreas, Kaupmann, Klemens, Dawson, Janet, Hoegenauer, Klemens, Orain, David, Hintermann, Samuel, Stringer, Rowan, Patel, Dhavalkumar D, Doelemeyer, Arno, Deurinck, Mark, Schümann, Jens

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Design and Synthesis of Selective and Potent Orally Active S1P5 Agonists von Mattes, Henri, Dev, Kumlesh Kumar, Bouhelal, Rochdi, Barske, Carmen, Gasparini, Fabrizio, Guerini, Danilo, Mir, Anis Khusro, Orain, David, Osinde, Maribel, Picard, Anne, Dubois, Celine, Tasdelen, Engin, Haessig, Samuel

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Concise Synthesis of 1H-Pyrazin-2-ones and 2-Aminopyrazines von Adam, Isabelle, Orain, David, Meier, Peter

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Structural States of RORγt: X‐ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds von Kallen, Joerg, Izaac, Aude, Be, Celine, Arista, Luca, Orain, David, Kaupmann, Klemens, Guntermann, Christine, Hoegenauer, Klemens, Hintermann, Samuel

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Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis von Velcicky, Juraj, Miltz, Wolfgang, Oberhauser, Berndt, Orain, David, Vaupel, Andrea, Weigand, Klaus, Dawson King, Janet, Littlewood-Evans, Amanda, Nash, Mark, Feifel, Roland, Loetscher, Pius

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Thiazole-Based IL-17 Inhibitors Discovered by Scaffold Morphing von Velcicky, Juraj, Ngo, Estelle, Bauer, Matthias R, Meyer, Arndt, Schlapbach, Achim, Racine, Sophie, Orain, David, Pflieger, Daniel, Teixeira-Fouchard, Sylvie, Dubois, Celine, Goetz, Alban, Steiner, Roland, Palmieri, Marco, Bussenault, Alex, Stringer, Rowan, Larger, Patrice, Riek, Simone, Schmutz, Patrick, Lehmann, Sylvie, Scheufler, Clemens, Rondeau, Jean-Michel, Burkhart, Christoph, Knoepfel, Thomas, Gommermann, Nina

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Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model von Carcache, David A, Vulpetti, Anna, Kallen, Joerg, Mattes, Henri, Orain, David, Stringer, Rowan, Vangrevelinghe, Eric, Wolf, Romain M, Kaupmann, Klemens, Ottl, Johannes, Dawson, Janet, Cooke, Nigel G, Hoegenauer, Klemens, Billich, Andreas, Wagner, Juergen, Guntermann, Christine, Hintermann, Samuel

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Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists von Hintermann, Samuel, Guntermann, Christine, Mattes, Henri, Carcache, David A., Wagner, Juergen, Vulpetti, Anna, Billich, Andreas, Dawson, Janet, Kaupmann, Klemens, Kallen, Joerg, Stringer, Rowan, Orain, David

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Pharmacological inhibition of ROR[gamma]t suppresses the Th17 pathway and alleviates arthritis in vivo von Guendisch, Ulf, Weiss, Jessica, Ecoeur, Florence, Riker, Julia Christina, Kaupmann, Klemens, Kallen, Joerg, Hintermann, Samuel, Orain, David, Dawson, Janet, Billich, Andreas, Guntermann, Christine

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Linkers and Cleavage Strategies in Solid-Phase Organic Synthesis and Combinatorial Chemistry. (Chem. Rev. 2000, 100, 2091. Published on the Web May 6, 2000) von Guillier, Fabrice, Orain, David, Bradley, Mark

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Structural States of ROR[gamma]t: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds von Kallen, Joerg, Izaac, Aude, Be, Celine, Arista, Luca, Orain, David, Kaupmann, Klemens, Guntermann, Christine, Hoegenauer, Klemens, Hintermann, Samuel

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Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity von Spanka, Carsten, Glatthar, Ralf, Desrayaud, Sandrine, Fendt, Markus, Orain, David, Troxler, Thomas, Vranesic, Ivo

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From Solution-Phase Studies to Solid-Phase Synthesis: A New Indole Based Scaffold for Combinatorial Chemistry von Orain, David, Koch, Guido, Giger, Rudolf

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BZM055, an Iodinated Radiotracer Candidate for PET and SPECT Imaging of Myelin and FTY720 Brain Distribution von Briard, Emmanuelle, Orain, David, Beerli, Christian, Billich, Andreas, Streiff, Markus, Bigaud, Marc, Auberson, Yves P.

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Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists von Koller, Manuel, Carcache, David A., Orain, David, Ertl, Peter, Behnke, Dirk, Desrayaud, Sandrine, Laue, Grit, Vranesic, Ivo

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