TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1 von Dibble, Christian C., Elis, Winfried, Menon, Suchithra, Qin, Wei, Klekota, Justin, Asara, John M., Finan, Peter M., Kwiatkowski, David J., Murphy, Leon O., Manning, Brendan D.

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Genetic Etiologies, Diagnosis, and Treatment of Tuberous Sclerosis Complex von Salussolia, Catherine L, Klonowska, Katarzyna, Kwiatkowski, David J, Sahin, Mustafa

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Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing von Tyburczy, Magdalena E, Dies, Kira A, Glass, Jennifer, Camposano, Susana, Chekaluk, Yvonne, Thorner, Aaron R, Lin, Ling, Krueger, Darcy, Franz, David N, Thiele, Elizabeth A, Sahin, Mustafa, Kwiatkowski, David J

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Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment von Tang, Yan, Kwiatkowski, David J., Henske, Elizabeth P.

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Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways von Yecies, Jessica L., Zhang, Hui H., Menon, Suchithra, Liu, Sihao, Yecies, Derek, Lipovsky, Alex I., Gorgun, Cem, Kwiatkowski, David J., Hotamisligil, Gökhan S., Lee, Chih-Hao, Manning, Brendan D.

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Perivascular epithelioid cell neoplasms: pathology and pathogenesis von Folpe, Andrew L., MD, Kwiatkowski, David J., MD, PhD

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Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas von Campbell, Joshua D, Alexandrov, Anton, Kim, Jaegil, Wala, Jeremiah, Berger, Alice H, Pedamallu, Chandra Sekhar, Shukla, Sachet A, Guo, Guangwu, Brooks, Angela N, Murray, Bradley A, Imielinski, Marcin, Hu, Xin, Ling, Shiyun, Akbani, Rehan, Rosenberg, Mara, Cibulskis, Carrie, Ramachandran, Aruna, Collisson, Eric A, Kwiatkowski, David J, Lawrence, Michael S, Weinstein, John N, Verhaak, Roel G W, Wu, Catherine J, Hammerman, Peter S, Cherniack, Andrew D, Getz, Gad, Artyomov, Maxim N, Schreiber, Robert, Govindan, Ramaswamy, Meyerson, Matthew

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A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations von Zhang, Yiqun, Kwok-Shing Ng, Patrick, Kucherlapati, Melanie, Chen, Fengju, Liu, Yuexin, Tsang, Yiu Huen, de Velasco, Guillermo, Jeong, Kang Jin, Akbani, Rehan, Hadjipanayis, Angela, Pantazi, Angeliki, Bristow, Christopher A., Lee, Eunjung, Mahadeshwar, Harshad S., Tang, Jiabin, Zhang, Jianhua, Yang, Lixing, Seth, Sahil, Lee, Semin, Ren, Xiaojia, Song, Xingzhi, Sun, Huandong, Seidman, Jonathan, Luquette, Lovelace J., Xi, Ruibin, Chin, Lynda, Protopopov, Alexei, Westbrook, Thomas F., Shelley, Carl Simon, Choueiri, Toni K., Ittmann, Michael, Van Waes, Carter, Weinstein, John N., Liang, Han, Henske, Elizabeth P., Godwin, Andrew K., Park, Peter J., Kucherlapati, Raju, Scott, Kenneth L., Mills, Gordon B., Kwiatkowski, David J., Creighton, Chad J.

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An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers von Chan, Kin, Roberts, Steven A, Klimczak, Leszek J, Sterling, Joan F, Saini, Natalie, Malc, Ewa P, Kim, Jaegil, Kwiatkowski, David J, Fargo, David C, Mieczkowski, Piotr A, Getz, Gad, Gordenin, Dmitry A

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Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International As... von Lindeman, Neal I., Cagle, Philip T., Beasley, Mary Beth, Chitale, Dhananjay Arun, Dacic, Sanja, Giaccone, Giuseppe, Jenkins, Robert Brian, Kwiatkowski, David J., Saldivar, Juan-Sebastian, Squire, Jeremy, Thunnissen, Erik, Ladanyi, Marc

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MET IHC Is a Poor Screen for MET Amplification or MET Exon 14 Mutations in Lung Adenocarcinomas: Data from a Tri-Institutional Cohort of the Lung Cancer Mutation Consortium von Guo, Robin, Berry, Lynne D., Aisner, Dara L., Sheren, Jamie, Boyle, Theresa, Bunn, Paul A., Johnson, Bruce E., Kwiatkowski, David J., Drilon, Alexander, Sholl, Lynette M., Kris, Mark G.

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Somatic LKB1 mutations promote cervical cancer progression von Wingo, Shana N, Gallardo, Teresa D, Akbay, Esra A, Liang, Mei-Chi, Contreras, Cristina M, Boren, Todd, Shimamura, Takeshi, Miller, David S, Sharpless, Norman E, Bardeesy, Nabeel, Kwiatkowski, David J, Schorge, John O, Wong, Kwok-Kin, Castrillon, Diego H

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Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs von Kris, Mark G, Johnson, Bruce E, Berry, Lynne D, Kwiatkowski, David J, Iafrate, A. John, Wistuba, Ignacio I, Varella-Garcia, Marileila, Franklin, Wilbur A, Aronson, Samuel L, Su, Pei-Fang, Shyr, Yu, Camidge, D. Ross, Sequist, Lecia V, Glisson, Bonnie S, Khuri, Fadlo R, Garon, Edward B, Pao, William, Rudin, Charles, Schiller, Joan, Haura, Eric B, Socinski, Mark, Shirai, Keisuke, Chen, Heidi, Giaccone, Giuseppe, Ladanyi, Marc, Kugler, Kelly, Minna, John D, Bunn, Paul A

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A Consensus Molecular Classification of Muscle-invasive Bladder Cancer von Kamoun, Aurélie, de Reyniès, Aurélien, Allory, Yves, Sjödahl, Gottfrid, Robertson, A. Gordon, Seiler, Roland, Hoadley, Katherine A., Groeneveld, Clarice S., Al-Ahmadie, Hikmat, Choi, Woonyoung, Castro, Mauro A.A., Fontugne, Jacqueline, Eriksson, Pontus, Mo, Qianxing, Kardos, Jordan, Zlotta, Alexandre, Hartmann, Arndt, Dinney, Colin P., Bellmunt, Joaquim, Powles, Thomas, Malats, Núria, Chan, Keith S., Kim, William Y., McConkey, David J., Black, Peter C., Dyrskjøt, Lars, Höglund, Mattias, Lerner, Seth P., Real, Francisco X., Radvanyi, François, Aine, Mattias, Al-Ahmadie, Hikmat, Allory, Yves, Bellmunt, Joaquim, Bernard-Pierrot, Isabelle, Black, Peter C., Castro, Mauro A.A., Chan, Keith S., Choi, Woonyoung, Czerniak, Bogdan, Dinney, Colin P., Dyrskjøt, Lars, Eriksson, Pontus, Fontugne, Jacqueline, Gibb, Ewan A., Groeneveld, Clarice S., Hartmann, Arndt, Hoadley, Katherine A., Höglund, Mattias, Kamoun, Aurélie, Kardos, Jordan, Kim, Jaegil, Kim, William Y., Kwiatkowski, David J., Lebret, Thierry, Lerner, Seth P., Liedberg, Fredrik, Malats, Núria, McConkey, David J., Mo, Qianxing, Powles, Thomas, Radvanyi, François, Real, Francisco X., de Reyniès, Aurélien, Robertson, A. Gordon, Siefker-Radtke, Arlene, Sirab, Nanor, Seiler, Roland, Sjödahl, Gottfrid, Taber, Ann, Weinstein, John, Zlotta, Alexandre

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Mutational Analysis of 472 Urothelial Carcinoma Across Grades and Anatomic Sites von Nassar, Amin H, Umeton, Renato, Kim, Jaegil, Lundgren, Kevin, Harshman, Lauren, Van Allen, Eliezer M, Preston, Mark, Dong, Fei, Bellmunt, Joaquim, Mouw, Kent W, Choueiri, Toni K, Sonpavde, Guru, Kwiatkowski, David J

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Equivalent benefit of rapamycin and a potent mTOR ATP-competitive inhibitor, MLN0128 (INK128), in a mouse model of tuberous sclerosis von Guo, Yanan, Kwiatkowski, David J

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mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion von Liu, Heng-Jia, Du, Heng, Khabibullin, Damir, Zarei, Mahsa, Wei, Kevin, Freeman, Gordon J., Kwiatkowski, David J., Henske, Elizabeth P.

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Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International As... von Lindeman, Neal I, Cagle, Philip T, Beasley, Mary Beth, Chitale, Dhananjay Arun, Dacic, Sanja, Giaccone, Giuseppe, Jenkins, Robert Brian, Kwiatkowski, David J, Saldivar, Juan-Sebastian, Squire, Jeremy, Thunnissen, Erik, Ladanyi, Marc

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Coordinated regulation of protein synthesis and degradation by mTORC1 von Zhang, Yinan, Nicholatos, Justin, Dreier, John R., Ricoult, Stéphane J. H., Widenmaier, Scott B., Hotamisligil, Gökhan S., Kwiatkowski, David J., Manning, Brendan D.

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Prevention of Epilepsy in Infants with Tuberous Sclerosis Complex in the EPISTOP Trial von Kotulska, Katarzyna, Kwiatkowski, David J., Curatolo, Paolo, Weschke, Bernhard, Riney, Kate, Jansen, Floor, Feucht, Martha, Krsek, Pavel, Nabbout, Rima, Jansen, Anna C., Wojdan, Konrad, Sijko, Kamil, Głowacka‐Walas, Jagoda, Borkowska, Julita, Sadowski, Krzysztof, Domańska‐Pakieła, Dorota, Moavero, Romina, Hertzberg, Christoph, Hulshof, Hanna, Scholl, Theresa, Benova, Barbora, Aronica, Eleonora, Ridder, Jessie, Lagae, Lieven, Jóźwiak, Sergiusz, Anink, J., Aronica, E., Benova, B., Benvenuto, A., Blazejczyk, M., Bongaerts, A., Borkowska, J., Breuillard, D., Chmielewski, D., Curatolo, P., Dabrowska, M., Domańska‐Pakieła, D., Feucht, M., Giannikou, K., Głowacka‐Walas, J., Hamieh, L., Harȩza, A., Hertzberg, Ch, Hulshof, H., Huschner, F., Iyer, A., Jansen, A., Jansen, F., Janssen, B., Jaworski, J., Jùźwiak, S., Kaczorowska‐Frontczak, M., Kotulska, K., Krsek, P., Kwiatkowski, D., Lagae, L., Lehmann, K., Leusman, A., Maćkowiak, N., Mills, J., Moavero, R., Muelebner, A., Nabbout, R., Ridder, J., Riney, K., Sadowski, K., Samueli, S., Scheldeman, C., Scholl, T., Sciuto, A., Sijko, K., Słowińska, M., Tempes, A., Scheppingen, J., Verhelle, B., Vervisch, J., Urbańska, M., Weschke, B., Wojdan, K.

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