Harnessing Fc receptor biology in the design of therapeutic antibodies von Sondermann, Peter, Szymkowski, David E

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Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination von Madsen, Pernille M, Motti, Dario, Karmally, Shaffiat, Szymkowski, David E, Lambertsen, Kate Lykke, Bethea, John R, Brambilla, Roberta

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Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia von Clausen, Bettina Hjelm, Degn, Matilda, Martin, Nellie Anne, Couch, Yvonne, Karimi, Leena, Ormhøj, Maria, Mortensen, Maria-Louise Bergholdt, Gredal, Hanne Birgit, Gardiner, Chris, Sargent, Ian I L, Szymkowski, David E, Petit, Géraldine H, Deierborg, Tomas, Finsen, Bente, Anthony, Daniel Clive, Lambertsen, Kate Lykke

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Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice von Yli-Karjanmaa, Minna, Clausen, Bettina Hjelm, Degn, Matilda, Novrup, Hans Gram, Ellman, Ditte Gry, Toft-Jensen, Peter, Szymkowski, David E, Stensballe, Allan, Meyer, Morten, Brambilla, Roberta, Lambertsen, Kate Lykke

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Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine von Vanwalleghem, Gilles, Morias, Yannick, Beschin, Alain, Szymkowski, David E., Pays, Etienne

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Soluble TNF mediates the transition from pulmonary inflammation to fibrosis von Oikonomou, Nikos, Harokopos, Vaggelis, Zalevsky, Jonathan, Valavanis, Christos, Kotanidou, Anastasia, Szymkowski, David E, Kollias, George, Aidinis, Vassilis

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Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia von Karamita, Maria, Barnum, Christopher, Möbius, Wiebke, Tansey, Malú G, Szymkowski, David E, Lassmann, Hans, Probert, Lesley

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Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats von Sama, Diana M, Mohmmad Abdul, Hafiz, Furman, Jennifer L, Artiushin, Irina A, Szymkowski, David E, Scheff, Stephen W, Norris, Christopher M

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Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody von Chu, Seung Y., PhD, Horton, Holly M., PhD, Pong, Erik, MS, Leung, Irene W.L., PhD, Chen, Hsing, MS, Nguyen, Duc-Hanh, BS, Bautista, Cristina, BS, Muchhal, Umesh S., PhD, Bernett, Matthew J., PhD, Moore, Gregory L., PhD, Szymkowski, David E., PhD, Desjarlais, John R., PhD

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Dominant-Negative Inhibitors of Soluble TNF Attenuate Experimental Arthritis without Suppressing Innate Immunity to Infection von Zalevsky, Jonathan, Secher, Thomas, Ezhevsky, Sergei A, Janot, Laure, Steed, Paul M, O'Brien, Christopher, Eivazi, Araz, Kung, James, Nguyen, Duc-Hanh T, Doberstein, Stephen K, Erard, Francois, Ryffel, Bernhard, Szymkowski, David E

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Inhibition of B cell activation following in vivo co-engagement of B cell antigen receptor and Fcγ receptor IIb in non-autoimmune-prone and SLE-prone mice von Chu, Seung Y., Pong, Erik, Bonzon, Christine, Yu, Ning, Jacob, Chaim O., Chalmers, Samantha A., Putterman, Chaim, Szymkowski, David E., Stohl, William

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Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination von Brambilla, Roberta, Ashbaugh, Jessica Jopek, Magliozzi, Roberta, Dellarole, Anna, Karmally, Shaffiat, Szymkowski, David E., Bethea, John R.

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Dominant-Negative Tumor Necrosis Factor Protects from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and Endotoxin-Induced Liver Injury without Compromising Host Immunity to BC... von Olleros, Maria L., Vesin, Dominique, Lambou, Agathe F., Janssens, Jean-Paul, Ryffel, Bernhard, Rose, Stéphanie, Frémond, Cécile, Quesniaux, Valérie F., Szymkowski, David E., Garcia, Irene

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Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-κB von Taoufik, Era, Tseveleki, Vivian, Chu, Seung Y., Tselios, Theodore, Karin, Michael, Lassmann, Hans, Szymkowski, David E., Probert, Lesley

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Blocking Soluble Tumor Necrosis Factor Signaling with Dominant-Negative Tumor Necrosis Factor Inhibitor Attenuates Loss of Dopaminergic Neurons in Models of Parkinson's Disease von McCoy, Melissa K, Martinez, Terina N, Ruhn, Kelly A, Szymkowski, David E, Smith, Christine G, Botterman, Barry R, Tansey, Keith E, Tansey, Malu G

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The TNF superfamily in 2009: new pathways, new indications, and new drugs von Tansey, Malú G., Szymkowski, David E.

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Neutralization of membrane TNF, but not soluble TNF, is crucial for the treatment of experimental colitis von Perrier, Clémentine, de Hertogh, Gert, Cremer, Jonathan, Vermeire, Severine, Rutgeerts, Paul, Van Assche, Gert, Szymkowski, David E, Ceuppens, Jan L

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Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus von Horton, Holly M, Chu, Seung Y, Ortiz, Elizabeth C, Pong, Erik, Cemerski, Saso, Leung, Irene W L, Jacob, Noam, Zalevsky, Jonathan, Desjarlais, John R, Stohl, William, Szymkowski, David E

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Inhibition of TNF reduces mechanical orofacial hyperalgesia induced by Complete Freund’s Adjuvant by a TRPV1-dependent mechanism in mice von Lis, Krzysztof, Grygorowicz, Tomasz, Cudna, Agnieszka, Szymkowski, David E., Bałkowiec-Iskra, Ewa

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Accelerated Clearance and Degradation of Cell-Free HIV by Neutralizing Antibodies Occurs via FcγRIIb on Liver Sinusoidal Endothelial Cells by Endocytosis von Turman, James M, Cheplowitz, Alana M, Tiwari, Charu, Thomas, Thushara, Joshi, Dhruvi, Bhat, Menakshi, Wu, Qian, Pong, Erik, Chu, Seung Y, Szymkowski, David E, Sharma, Amit, Seveau, Stephanie, Robinson, John M, Kwiek, Jesse J, Burton, Dennis, Rajaram, Murugesan V S, Kim, Jonghan, Hangartner, Lars, Ganesan, Latha P

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