Antibody-Drug Conjugates: Future Directions in Clinical and Translational Strategies to Improve the Therapeutic Index von Coats, Steven, Williams, Marna, Kebble, Benjamin, Dixit, Rakesh, Tseng, Leo, Yao, Nai-Shun, Tice, David A, Soria, Jean-Charles

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MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgro... von Greer, Yoshimi Endo, Gilbert, Samuel F, Gril, Brunilde, Narwal, Rajesh, Peacock Brooks, Danielle L, Tice, David A, Steeg, Patricia S, Lipkowitz, Stanley

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SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads von Kinneer, Krista, Meekin, John, Tiberghien, Arnaud C, Tai, Yu-Tzu, Phipps, Sandrina, Kiefer, Christine Mione, Rebelatto, Marlon C, Dimasi, Nazzareno, Moriarty, Alyssa, Papadopoulos, Kyriakos P, Sridhar, Sriram, Gregson, Stephen J, Wick, Michael J, Masterson, Luke, Anderson, Kenneth C, Herbst, Ronald, Howard, Philip W, Tice, David A

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EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner: Implications for EphB4 as a cancer target von Xiao, Zhan, Carrasco, Rosa, Kinneer, Krista, Sabol, Darrin, Jallal, Bahija, Coats, Steve, Tice, David A.

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A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways von Rios-Doria, Jonathan, Sabol, Darrin, Chesebrough, Jon, Stewart, Dave, Xu, Linda, Tammali, Ravinder, Cheng, Li, Du, Qun, Schifferli, Kevin, Rothstein, Ray, Leow, Ching Ching, Heidbrink-Thompson, Jenny, Jin, Xiaofang, Gao, Changshou, Friedman, Jay, Wilkinson, Brandy, Damschroder, Melissa, Pierce, Andrew J, Hollingsworth, Robert E, Tice, David A, Michelotti, Emil F

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Multivalent scaffold proteins as superagonists of TRAIL receptor 2-induced apoptosis von Swers, Jeffery S, Grinberg, Luba, Wang, Lin, Feng, Hui, Lekstrom, Kristen, Carrasco, Rosa, Xiao, Zhan, Inigo, Ivan, Leow, Ching Ching, Wu, Herren, Tice, David A, Baca, Manuel

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Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells von Kolluri, Krishna Kalyan, Alifrangis, Constantine, Kumar, Neelam, Ishii, Yuki, Price, Stacey, Michaut, Magali, Williams, Steven, Barthorpe, Syd, Lightfoot, Howard, Busacca, Sara, Sharkey, Annabel, Yuan, Zhenqiang, Sage, Elizabeth K, Vallath, Sabarinath, Le Quesne, John, Tice, David A, Alrifai, Doraid, von Karstedt, Sylvia, Montinaro, Antonella, Guppy, Naomi, Waller, David A, Nakas, Apostolos, Good, Robert, Holmes, Alan, Walczak, Henning, Fennell, Dean A, Garnett, Mathew, Iorio, Francesco, Wessels, Lodewyk, McDermott, Ultan, Janes, Samuel M

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In Vivo Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors von Pore, Nabendu, Jalla, Sanjoo, Liu, Zheng, Higgs, Brandon, Sorio, Claudio, Scarpa, Aldo, Hollingsworth, Robert, Tice, David A, Michelotti, Emil

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IL-6 Inhibition With MEDI5117 Decreases The Fraction of Head and Neck Cancer Stem Cells and Prevents Tumor Recurrence von Finkel, Kelsey A, Warner, Kristy A, Kerk, Samuel, Bradford, Carol R, McLean, Scott A, Prince, Mark E, Zhong, Haihong, Hurt, Elaine M, Hollingsworth, Robert E, Wicha, Max S, Tice, David A, Nör, Jacques E

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Mechanism of Biological Synergy between Cellular Src and Epidermal Growth Factor Receptor von Tice, David A., Biscardi, Jacqueline S., Nickles, Amanda L., Parsons, Sarah J.

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Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer von Bosco, Emily E, Christie, R James, Carrasco, Rosa, Sabol, Darrin, Zha, Jiping, DaCosta, Karma, Brown, Lee, Kennedy, Maureen, Meekin, John, Phipps, Sandrina, Ayriss, Joanne, Du, Qun, Bezabeh, Binyam, Chowdhury, Partha, Breen, Shannon, Chen, Cui, Reed, Molly, Hinrichs, MaryJane, Zhong, Haihong, Xiao, Zhan, Dixit, Rakesh, Herbst, Ronald, Tice, David A

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Src family kinases and HER2 interactions in human breast cancer cell growth and survival von BELSCHES-JABLONSKI, Allison P, BISCARDI, Jacqueline S, PEAVY, Dena R, TICE, David A, ROMNEY, Davis A, PARSONS, Sarah J

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Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305 von Kinneer, Krista, Wortmann, Philipp, Cooper, Zachary A, Dickinson, Niall J, Masterson, Luke, Cailleau, Thais, Hutchinson, Ian, Vijayakrishnan, Balakumar, McFarlane, Mary, Ball, Kathryn, Davies, Michael, Lewis, Arthur, Huang, Yue, Rosenbaum, Anton I, Yuan, Jiaqi, Chesebrough, Jon, Anderton, Judith, Monks, Noel, Novick, Steven, Wang, Jixin, Dimasi, Nazzareno, Christie, R James, Sabol, Darrin, Tosto, Frances Anne, Wallez, Yann, Leo, Elisabetta, Albertella, Mark R, Staniszewska, Anna D, Tice, David A, Howard, Philip W, Luheshi, Nadia, Sapra, Puja

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Controlling CAR-T cell activity and specificity with synthetic SparX adapters von Edwards, Justin P., Swers, Jeffrey S., Buonato, Janine M., Zaritskaya, Liubov, Mu, C. Jenny, Gupta, Ankit, Shachar, Sigal, LaFleur, David W., Richman, Laura K., Tice, David A., Hilbert, David M.

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Preclinical assessment of an antibody–PBD conjugate that targets BCMA on multiple myeloma and myeloma progenitor cells von Kinneer, Krista, Flynn, Matt, Thomas, Suneetha B., Meekin, John, Varkey, Reena, Xiao, Xiaodong, Zhong, Haihong, Breen, Shannon, Hynes, Paul G., Fleming, Ryan, Bezabeh, Binyam, Chen, Cui (Tracy), Wetzel, Leslie, Chen, Ruoyan, Dimasi, Nazzareno, Tai, Yu-Tzu, Anderson, Kenneth C., Herbst, Ronald, Howard, Philip W., Hurt, Elaine M., Tice, David A.

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Preclinical Efficacy of BCMA-Directed CAR T Cells Incorporating a Novel D Domain Antigen Recognition Domain von Buonato, Janine M, Edwards, Justin P, Zaritskaya, Liubov, Witter, Alexandra R, Gupta, Ankit, LaFleur, David W, Tice, David A, Richman, Laura K, Hilbert, David M

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Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR von Mao, Shenlan, Chaerkady, Raghothama, Yu, Wen, D'Angelo, Gina, Garcia, Andrew, Chen, Hong, Barrett, Allison M, Phipps, Sandrina, Fleming, Ryan, Hess, Sonja, Koopmann, Jens-Oliver, Dimasi, Nazzareno, Wilson, Susan, Pugh, Kathryn, Cook, Kimberly, Masterson, Luke A, Gao, Changshou, Wu, Herren, Herbst, Ronald, Howard, Philip W, Tice, David A, Cobbold, Mark, Harper, Jay

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Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression von Sungalee, Stéphanie, Mamessier, Emilie, Morgado, Ester, Grégoire, Emilie, Brohawn, Philip Z, Morehouse, Christopher A, Jouve, Nathalie, Monvoisin, Céline, Menard, Cédric, Debroas, Guilhaume, Faroudi, Mustapha, Mechin, Violaine, Navarro, Jean-Marc, Drevet, Charlotte, Eberle, Franziska C, Chasson, Lionel, Baudimont, Fannie, Mancini, Stéphane J, Tellier, Julie, Picquenot, Jean-Michel, Kelly, Rachel, Vineis, Paolo, Ruminy, Philippe, Chetaille, Bruno, Jaffe, Elaine S, Schiff, Claudine, Hardwigsen, Jean, Tice, David A, Higgs, Brandon W, Tarte, Karin, Nadel, Bertrand, Roulland, Sandrine

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Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells von Yang, Nai-Ying, Fernandez, Carlos, Richter, Melanie, Xiao, Zhan, Valencia, Fatima, Tice, David A., Pasquale, Elena B.

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A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors von Zhong, Haihong, Davis, April, Ouzounova, Maria, Carrasco, Rosa A, Chen, Cui, Breen, Shannon, Chang, Yong S, Huang, Jiaqi, Liu, Zheng, Yao, Yihong, Hurt, Elaine, Moisan, Jacques, Fung, Michael, Tice, David A, Clouthier, Shawn G, Xiao, Zhan, Wicha, Max S, Korkaya, Hasan, Hollingsworth, Robert E

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