“Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4”: Revisiting the Significance of the Epoxide Intermediate and Glutathione Trapping von Veeravalli, Vijayabhaskar, Dash, Ranjeet P

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Critical Assessment of Pharmacokinetic Drug–Drug Interaction Potential of Tofacitinib, Baricitinib and Upadacitinib, the Three Approved Janus Kinase Inhibitors for Rheumatoid Arthr... von Veeravalli, Vijayabhaskar, Dash, Ranjeet P., Thomas, Jennifer A., Babu, R. Jayachandra, Madgula, Lakshmi Mohan Vamsi, Srinivas, Nuggehally R.

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Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold von Stepanek, Ondrej, Hin, Niyada, Thomas, Ajit G., Dash, Ranjeet P., Alt, Jesse, Rais, Rana, Rojas, Camilo, Slusher, Barbara S., Tsukamoto, Takashi

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Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo von Ghosh, Arijit, Li, Ling, Xu, Liyi, Dash, Ranjeet P, Gupta, Neha, Lam, Jenny, Jin, Qianru, Akshintala, Venkata, Pahapale, Gayatri, Liu, Wangqu, Sarkar, Anjishnu, Rais, Rana, Gracias, David H, Selaru, Florin M

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Whole blood or plasma: what is the ideal matrix for pharmacokinetic-driven drug candidate selection? von Dash, Ranjeet P, Veeravalli, Vijayabhaskar, Thomas, Jennifer A, Rosenfeld, Clint, Mehta, Nirali, Srinivas, Nuggehally R

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Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease von Šála, Michal, Hollinger, Kristen R, Thomas, Ajit G, Dash, Ranjeet P, Tallon, Carolyn, Veeravalli, Vijayabhaskar, Lovell, Lyndah, Kögler, Martin, Hřebabecký, Hubert, Procházková, Eliška, Nešuta, Ondřej, Donoghue, Amanda, Lam, Jenny, Rais, Rana, Rojas, Camilo, Slusher, Barbara S, Nencka, Radim

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A novel and potent brain penetrant inhibitor of extracellular vesicle release von Rojas, Camilo, Sala, Michal, Thomas, Ajit G., Datta Chaudhuri, Amrita, Yoo, Seung‐Wan, Li, Zhigang, Dash, Ranjeet P., Rais, Rana, Haughey, Norman J., Nencka, Radim, Slusher, Barbara

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Tumor-Targeted Delivery of 6‑Diazo-5-oxo‑l‑norleucine (DON) Using Substituted Acetylated Lysine Prodrugs von Tenora, Lukáš, Alt, Jesse, Dash, Ranjeet P, Gadiano, Alexandra J, Novotná, Kateřina, Veeravalli, Vijayabhaskar, Lam, Jenny, Kirkpatrick, Quinn R, Lemberg, Kathryn M, Majer, Pavel, Rais, Rana, Slusher, Barbara S

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JHU-2545 preferentially shields salivary glands and kidneys during PSMA-targeted imaging von Nedelcovych, Michael T, Dash, Ranjeet P, Wu, Ying, Choi, Eun Yong, Lapidus, Rena S, Majer, Pavel, Jančařík, Andrej, Abou, Diane, Penet, Marie-France, Nikolopoulou, Anastasia, Amor-Coarasa, Alex, Babich, John, Thorek, Daniel L, Rais, Rana, Kratochwil, Clemens, Slusher, Barbara S

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Increased intestinal P-glycoprotein expression and activity with progression of diabetes and its modulation by epigallocatechin-3-gallate: Evidence from pharmacokinetic studies von Dash, Ranjeet Prasad, Ellendula, Bhanuchander, Agarwal, Milee, Nivsarkar, Manish

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Two Decades-Long Journey from Riluzole to Edaravone: Revisiting the Clinical Pharmacokinetics of the Only Two Amyotrophic Lateral Sclerosis Therapeutics von Dash, Ranjeet Prasad, Babu, R. Jayachandra, Srinivas, Nuggehally R.

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Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain von Rais, Rana, Vávra, Jan, Tichý, Tomáš, Dash, Ranjeet P, Gadiano, Alexandra J, Tenora, Lukáš, Monincová, Lenka, Bařinka, Cyril, Alt, Jesse, Zimmermann, Sarah C, Slusher, C. Ethan, Wu, Ying, Wozniak, Krystyna, Majer, Pavel, Tsukamoto, Takashi, Slusher, Barbara S

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Role of mucoadhesive polymers in enhancing delivery of nimodipine microemulsion to brain via intranasal route von Pathak, Rudree, Dash, Ranjeet Prasad, Misra, Manju, Nivsarkar, Manish

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N‑Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs von Zimmermann, Sarah C, Tichý, Tomáš, Vávra, Jan, Dash, Ranjeet P, Slusher, C. Ethan, Gadiano, Alexandra J, Wu, Ying, Jančařík, Andrej, Tenora, Lukáš, Monincová, Lenka, Prchalová, Eva, Riggins, Gregory J, Majer, Pavel, Slusher, Barbara S, Rais, Rana

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N‑(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6‑Diazo-5-oxo‑l‑norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders von Nedelcovych, Michael T, Tenora, Lukáš, Kim, Boe-Hyun, Kelschenbach, Jennifer, Chao, Wei, Hadas, Eran, Jančařík, Andrej, Prchalová, Eva, Zimmermann, Sarah C, Dash, Ranjeet P, Gadiano, Alexandra J, Garrett, Caroline, Furtmüller, Georg, Oh, Byoungchol, Brandacher, Gerald, Alt, Jesse, Majer, Pavel, Volsky, David J, Rais, Rana, Slusher, Barbara S

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Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug von Rais, Rana, Lemberg, Kathryn M, Tenora, Lukáš, Arwood, Matthew L, Pal, Arindom, Alt, Jesse, Wu, Ying, Lam, Jenny, Aguilar, Joanna Marie H, Zhao, Liang, Peters, Diane E, Tallon, Carolyn, Pandey, Rajeev, Thomas, Ajit G, Dash, Ranjeet P, Seiwert, Tanguy, Majer, Pavel, Leone, Robert D, Powell, Jonathan D, Slusher, Barbara S

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Enhanced Oral Bioavailability of 2‑(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs von Dash, Ranjeet P, Tichý, Tomáš, Veeravalli, Vijayabhaskar, Lam, Jenny, Alt, Jesse, Wu, Ying, Tenora, Lukáš, Majer, Pavel, Slusher, Barbara S, Rais, Rana

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The Novel Glutamine Antagonist Prodrug JHU395 Has Antitumor Activity in Malignant Peripheral Nerve Sheath Tumor von Lemberg, Kathryn M, Zhao, Liang, Wu, Ying, Veeravalli, Vijayabhaskar, Alt, Jesse, Aguilar, Joanna Marie H, Dash, Ranjeet P, Lam, Jenny, Tenora, Lukáš, Rodriguez, Chabely, Nedelcovych, Michael T, Brayton, Cory, Majer, Pavel, Blakeley, Jaishri O, Rais, Rana, Slusher, Barbara S

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Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions? Observ... von Thakkar, Disha, Dash, Ranjeet Prasad

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Protein Binding and Stability of Drug Candidates: The Achilles’ Heel in In Vitro Potency Assays von Dash, Ranjeet P., Thomas, Jennifer A., Rosenfeld, Clint, Srinivas, Nuggehally R.

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