Do reactive oxygen species play a role in myeloid leukemias? von Hole, Paul Spencer, Darley, Richard Lawrence, Tonks, Alex

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Reactive Oxygen Species Drive Proliferation in Acute Myeloid Leukemia via the Glycolytic Regulator PFKFB3 von Robinson, Andrew J, Hopkins, Goitseone L, Rastogi, Namrata, Hodges, Marie, Doyle, Michelle, Davies, Sara, Hole, Paul S, Omidvar, Nader, Darley, Richard L, Tonks, Alex

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Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling von Hole, Paul S., Zabkiewicz, Joanna, Munje, Chinmay, Newton, Zarabeth, Pearn, Lorna, White, Paul, Marquez, Nuria, Hills, Robert K., Burnett, Alan K., Tonks, Alex, Darley, Richard L.

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Reactive Oxygen Species Rewires Metabolic Activity in Acute Myeloid Leukemia von Robinson, Andrew J, Davies, Sara, Darley, Richard L, Tonks, Alex

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LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells von Morgan, Rhys G, Ridsdale, Jenna, Payne, Megan, Heesom, Kate J, Wilson, Marieangela C, Davidson, Andrew, Greenhough, Alexander, Davies, Sara, Williams, Ann C, Blair, Allison, Waterman, Marian L, Tonks, Alex, Darley, Richard L

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Factors Affecting the Nuclear Localization of β-Catenin in Normal and Malignant Tissue von Morgan, Rhys G., Ridsdale, Jenna, Tonks, Alex, Darley, Richard L.

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Increased expression of RUNX3 inhibits normal human myeloid development von Menezes, Ana Catarina, Jones, Rachel, Shrestha, Alina, Nicholson, Rachael, Leckenby, Adam, Azevedo, Aleksandra, Davies, Sara, Baker, Sarah, Gilkes, Amanda F., Darley, Richard L., Tonks, Alex

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Crosstalk between β-catenin and WT1 signaling activity in acute myeloid leukemia von Wagstaff, Megan, Tsaponina, Olga, Caalim, Gilian, Greenfield, Hayley, Milton-Harris, Leanne, Mancini, Erika J, Blair, Allison, Heesom, Kate J, Tonks, Alex, Darley, Richard L, Roberts, Stefan G, Morgan, Rhys G

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Reactive oxygen species in leukemias: maintaining cancer cell proliferation via redox signaling and changing metabolic homeostasis von Robinson, Andrew J, Darley, Richard L, Tonks, Alex

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Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia von Alanazi, Bader, Munje, Chinmay R., Rastogi, Namrata, Williamson, Andrew J. K., Taylor, Samuel, Hole, Paul S., Hodges, Marie, Doyle, Michelle, Baker, Sarah, Gilkes, Amanda F., Knapper, Steven, Pierce, Andrew, Whetton, Anthony D., Darley, Richard L., Tonks, Alex

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RUNX3 overexpression inhibits normal human erythroid development von Menezes, Ana Catarina, Dixon, Christabel, Scholz, Anna, Nicholson, Rachael, Leckenby, Adam, Azevedo, Aleksandra, Baker, Sarah, Gilkes, Amanda F., Davies, Sara, Darley, Richard L., Tonks, Alex

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Use of an anti‐CD200‐blocking antibody improves immune responses to AML in vitro and in vivo von Rastogi, Namrata, Baker, Sarah, Man, Stephen, Uger, Robert A., Wong, Mark, Coles, Steven J., Hodges, Marie, Gilkes, Amanda F., Knapper, Steven, Darley, Richard L., Tonks, Alex

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CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis von Morgan, Huw J, Rees, Elise, Lanfredini, Simone, Powell, Kate A, Gore, Jasmine, Gibbs, Alex, Lovatt, Charlotte, Davies, Gemma E, Olivero, Carlotta, Shorning, Boris Y, Tornillo, Giusy, Tonks, Alex, Darley, Richard, Wang, Eddie Cy, Patel, Girish K

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The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts von Zabkiewicz, Joanna, Pearn, Lorna, Hills, Robert K, Morgan, Rhys G, Tonks, Alex, Burnett, Alan K, Darley, Richard L

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Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia von Rastogi, Namrata, Gonzalez, Juan Bautista Menendez, Srivastava, Vikas Kumar, Alanazi, Bader, Alanazi, Rehab N., Hughes, Owen M., O’Neill, Niamh S., Gilkes, Amanda F., Ashley, Neil, Deshpande, Sumukh, Andrews, Robert, Mead, Adam, Rodrigues, Neil P., Knapper, Steve, Darley, Richard L., Tonks, Alex

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Protein Kinase C Epsilon Overexpression Is Associated With Poor Patient Outcomes in AML and Promotes Daunorubicin Resistance Through p-Glycoprotein-Mediated Drug Efflux von Nicholson, Rachael, Menezes, Ana Catarina, Azevedo, Aleksandra, Leckenby, Adam, Davies, Sara, Seedhouse, Claire, Gilkes, Amanda, Knapper, Steve, Tonks, Alex, Darley, Richard L

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Ras-induced reactive oxygen species promote growth factor–independent proliferation in human CD34+ hematopoietic progenitor cells von Hole, Paul S., Pearn, Lorna, Tonks, Amanda J., James, Philip E., Burnett, Alan K., Darley, Richard L., Tonks, Alex

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Using Flow Cytometry to Detect and Measure Intracellular Thiol Redox Status in Viable T Cells from Heterogeneous Populations von Wadley, Alex J., Morgan, Rhys G., Darley, Richard L., Hole, Paul S., Coles, Steven J.

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Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants von Agathanggelou, Angelo, Weston, Victoria J, Perry, Tracey, Davies, Nicholas J, Skowronska, Anna, Payne, Daniel T, Fossey, John S, Oldreive, Ceri E, Wei, Wenbin, Pratt, Guy, Parry, Helen, Oscier, David, Coles, Steve J, Hole, Paul S, Darley, Richard L, McMahon, Michael, Hayes, John D, Moss, Paul, Stewart, Grant S, Taylor, A Malcolm R, Stankovic, Tatjana

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The role of PKC and PDK1 in monocyte lineage specification by Ras von Pearn, Lorna, Fisher, Janet, Burnett, Alan K., Darley, Richard L.

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