The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo von Lucas, David M., Edwards, Ryan B., Lozanski, Gerard, West, Derek A., Shin, Jungook D., Vargo, Melissa A., Davis, Melanie E., Rozewski, Darlene M., Johnson, Amy J., Su, Bao-Ning, Goettl, Virginia M., Heerema, Nyla A., Lin, Thomas S., Lehman, Amy, Zhang, Xiaoli, Jarjoura, David, Newman, David J., Byrd, John C., Kinghorn, A. Douglas, Grever, Michael R.

Volltext

Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia von Phelps, Mitch A., Lin, Thomas S., Johnson, Amy J., Hurh, Eunju, Rozewski, Darlene M., Farley, Katherine L., Wu, Di, Blum, Kristie A., Fischer, Beth, Mitchell, Sarah M., Moran, Mollie E., Brooker-McEldowney, Michelle, Heerema, Nyla A., Jarjoura, David, Schaaf, Larry J., Byrd, John C., Grever, Michael R., Dalton, James T.

Volltext

Phase I Trial of Lenalidomide and CCI-779 in Patients With Relapsed Multiple Myeloma: Evidence for Lenalidomide–CCI-779 Interaction via P-Glycoprotein von HOFMEISTER, Craig C, XIAOXIA YANG, JIA JI, SCHAAF, Larry J, BENSON, Don M, KRAUT, Eric H, HICKS, William J, CHAN, Kenneth K, CHEN, Ching-Shih, FARAG, Sherif S, GREVER, Michael R, BYRD, John C, PICHIORRI, Flavia, PHELPS, Mitch A, PING CHEN, ROZEWSKI, Darlene M, JOHNSON, Amy J, LEE, Seungsoo, ZHONGFA LIU, GARR, Celia L, HADE, Erinn M

Volltext

Dose Escalation of Lenalidomide in Relapsed or Refractory Acute Leukemias von William Blum, Rebecca B. Klisovic, Heiko Becker, Xiaoxia Yang, Darlene M. Rozewski, Mitch A. Phelps, Ramiro Garzon, Alison Walker, Jason C. Chandler, Susan P. Whitman, John Curfman, Shujun Liu, Larry Schaaf, Jon Mickle, Cheryl Kefauver, Steven M. Devine, Michael R. Grever, Guido Marcucci, and, John C. Byrd

Volltext

Sensitive liquid chromatography/mass spectrometry methods for quantification of pomalidomide in mouse plasma and brain tissue von Jiang, Yao, Wang, Jiang, Rozewski, Darlene M., Kolli, Shamalatha, Wu, Chia-Hsien, Chen, Ching-Shih, Yang, Xiaoxia, Hofmeister, Craig C., Byrd, John C., Johnson, Amy J., Phelps, Mitch A.

Volltext

Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias von BLUM, William, PHELPS, Mitch A, JOHNSON, Amy, SCHAAF, Larry J, BYRD, John C, MARCUCCI, Guido, GREVER, Michael R, KLISOVIC, Rebecca B, ROZEWSKI, Darlene M, WENJUN NI, ALBANESE, Katie A, ROVIN, Brad, KEFAUVER, Cheryl, DEVINE, Steven M, LUCAS, David M

Volltext

Pharmacokinetics and Tissue Disposition of Lenalidomide in Mice von Rozewski, Darlene M., Herman, Sarah E. M., Towns, William H., Mahoney, Emilia, Stefanovski, Matthew R., Shin, Jungook D., Yang, Xiaoxia, Gao, Yue, Li, Xiaobai, Jarjoura, David, Byrd, John C., Johnson, Amy J., Phelps, Mitch A.

Volltext

Development of a physiologically based pharmacokinetic model for intravenous lenalidomide in mice von Hughes, Jim H., Upton, Richard N., Reuter, Stephanie E., Rozewski, Darlene M., Phelps, Mitch A., Foster, David J. R.

Volltext

Development and validation of a sensitive liquid chromatography/mass spectrometry method for quantitation of flavopiridol in plasma enables accurate estimation of pharmacokinetic p... von Phelps, Mitch A., Rozewski, Darlene M., Johnston, Jeffrey S., Farley, Katherine L., Albanese, Katie A., Byrd, John C., Lin, Thomas S., Grever, Michael R., Dalton, James T.

Volltext

A novel liposomal formulation of flavopiridol von Yang, Xiaojuan, Zhao, Xiaobin, Phelps, Mitch A., Piao, Longzhu, Rozewski, Darlene M., Liu, Qing, Lee, L. James, Marcucci, Guido, Grever, Michael R., Byrd, John C., Dalton, James T., Lee, Robert J.

Volltext

A dose escalation feasibility study of lenalidomide for treatment of symptomatic, relapsed chronic lymphocytic leukemia von Maddocks, Kami, Ruppert, Amy S, Browning, Rebekah, Jones, Jeffrey, Flynn, Joseph, Kefauver, Cheryl, Gao, Yue, Jiang, Yao, Rozewski, Darlene M, Poi, Ming, Phelps, Mitch A, Harper, Erica, Johnson, Amy J, Byrd, John C, Andritsos, Leslie A

Volltext

Abstract 5473: The contribution of P-glycoprotein to clinical pharmacokinetic interactions between lenalidomide and temsirolimus von Yang, Xiaoxia, Craig, Hofmeister C., Rozewski, Darlene M., Lee, Seungsoo, Chen, Ping, Johnson, Amy J., Liu, Zhongfa, Hade, Erinn M., Ji, Jia, Schaaf, Larry J., Benson, Don M., Kraut, Eric H., Hicks, William J., Chan, Kenneth K., Chen, Ching-Shih, Farag, Sherif S., Grever, Michael R., Byrd, John C., Phelps, Mitch A.

Volltext

Pharmaceutical nanotechnology: A novel liposomal formulation of flavopiridol von Yang, Xiaojuan, Zhao, Xiaobin, Phelps, Mitch A, Piao, Longzhu, Rozewski, Darlene M, Liu, Qing, Lee, L James, Marcucci, Guido, Grever, Michael R, Byrd, John C, Dalton, James T, Lee, Robert J

Volltext

Activity of Combined Flavopiridol and Lenalidomide in Patients with Cytogenetically High Risk Chronic Lymphocytic Leukemia (CLL): Updated Results of a Phase I Trial von Blum, Kristie A., Wei, Lai, Jones, Jeffrey A., Andritsos, Leslie A, Flynn, Joseph M., Heerema, Nyla A., Yang, Xiaoxia, Rozewski, Darlene, Phelps, Mitchell, Johnson, Amy J, Grever, Michael R., Byrd, John C.

Volltext