Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma von Rieswijk, Linda, Claessen, Sandra M.H, Bekers, Otto, Herwijnen, Marcel van, Theunissen, Daniël H.J, Jennen, Danyel G.J, de Kok, Theo M.C.M, Kleinjans, Jos C.S, van Breda, Simone G.J

Volltext

Xenobiotic metabolism in differentiated human bronchial epithelial cells von Boei, Jan J. W. A., Vermeulen, Sylvia, Klein, Binie, Hiemstra, Pieter S., Verhoosel, Renate M., Jennen, Danyel G. J., Lahoz, Agustin, Gmuender, Hans, Vrieling, Harry

Volltext

Transcriptomic and metabolomic data integration von Cavill, Rachel, Jennen, Danyel, Kleinjans, Jos, Briedé, Jacob Jan

Volltext

Application of transfer learning to predict drug-induced human in vivo gene expression changes using rat in vitro and in vivo data von O'Donovan, Shauna D, Cavill, Rachel, Wimmenauer, Florian, Lukas, Alexander, Stumm, Tobias, Smirnov, Evgueni, Lenz, Michael, Ertaylan, Gokhan, Jennen, Danyel G. J, van Riel, Natal A. W, Driessens, Kurt, Peeters, Ralf L. M, de Kok, Theo M. C. M

Volltext

Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes von O'Donovan, Shauna D, Driessens, Kurt, Lopatta, Daniel, Wimmenauer, Florian, Lukas, Alexander, Neeven, Jelmer, Stumm, Tobias, Smirnov, Evgueni, Lenz, Michael, Ertaylan, Gokhan, Jennen, Danyel G J, van Riel, Natal A W, Cavill, Rachel, Peeters, Ralf L M, de Kok, Theo M C M

Volltext

New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids von Rodrigues, Daniela, de Souza, Terezinha, Coyle, Luke, Di Piazza, Matteo, Herpers, Bram, Ferreira, Sofia, Zhang, Mian, Vappiani, Johanna, Sévin, Daniel C., Gabor, Attila, Lynch, Anthony, Chung, Seung-Wook, Saez-Rodriguez, Julio, Jennen, Danyel G. J., Kleinjans, Jos C. S., de Kok, Theo M.

Volltext

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transpo... von Jiang, Jian, Briedé, Jacob J., Jennen, Danyel G.J., Van Summeren, Anke, Saritas-Brauers, Karen, Schaart, Gert, Kleinjans, Jos C.S., de Kok, Theo M.C.M.

Volltext

Integrating SNPs-based genetic risk factor with blood epigenomic response of differentially arsenic-exposed rural subjects reveals disease-associated signaling pathways von Rehman, Muhammad Yasir Abdur, Briedé, Jacco Jan, van Herwijnen, Marcel, Krauskopf, Julian, Jennen, Danyel G.J., Malik, Riffat Naseem, Kleinjans, Jos C.S.

Volltext

Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification von Jennen, Danyel G. J., Magkoufopoulou, Christina, Ketelslegers, Hans B., van Herwijnen, Marcel H. M., Kleinjans, Jos C. S., van Delft, Joost H. M.

Volltext

A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids von Rodrigues, Daniela, Herpers, Bram, Ferreira, Sofia, Jo, Heeseung, Fisher, Ciarán, Coyle, Luke, Chung, Seung-Wook, Kleinjans, Jos C S, Jennen, Danyel G J, de Kok, Theo M

Volltext

Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches von Rodrigues, Daniela, Souza, Terezinha, Jennen, Danyel G.J., Lemmens, Lieve, Kleinjans, Jos C.S., de Kok, Theo M.

Volltext

Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genom... von Smit, Evelyn, Souza, Terezinha, Jennen, Danyel G.J., Kleinjans, Jos C.S., van den Beucken, Twan

Volltext

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis von van Breda, Simone G. J., Claessen, Sandra M. H., Lo, Ken, van Herwijnen, Marcel, Brauers, Karen J. J., Lisanti, Sofia, Theunissen, Daniël H. J., Jennen, Danyel G. J., Gaj, Stan, de Kok, Theo M. C. M., Kleinjans, Jos C. S.

Volltext

Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response von Jennen, Danyel G J, van Herwijnen, Marcel, Jetten, Marlon, Vandebriel, Rob J, Keizers, Peter, Geertsma, Robert E, de Jong, Wim H, Kleinjans, Jos C S

Volltext

Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction von van Breda, Simone G.J., Claessen, Sandra M.H., van Herwijnen, Marcel, Theunissen, Daniël H.J., Jennen, Danyel G.J., de Kok, Theo M.C.M., Kleinjans, Jos C.S.

Volltext

Gene expression responses reflecting 5-FU-induced toxicity: Comparison between patient colon tissue and 3D human colon organoids von Rodrigues, Daniela, van Kampen, Roel, van Bodegraven, Ad A., Kleinjans, Jos C.S., Jennen, Danyel G.J., de Kok, Theo M.

Volltext

The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer von Bischoff, Nicolaj S, Proquin, Héloïse, Jetten, Marlon J, Schrooders, Yannick, Jonkhout, Marloes C M, Briedé, Jacco J, van Breda, Simone G, Jennen, Danyel G J, Medina-Reyes, Estefany I, Delgado-Buenrostro, Norma L, Chirino, Yolanda I, van Loveren, Henk, de Kok, Theo M

Volltext

A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity von Gall, Louis, Jardi, Ferran, Lammens, Lieve, Piñero, Janet, Souza, Terezinha M, Rodrigues, Daniela, Jennen, Danyel G J, de Kok, Theo M, Coyle, Luke, Chung, Seung-Wook, Ferreira, Sofia, Jo, Heeseung, Beattie, Kylie A, Kelly, Colette, Duckworth, Carrie A, Pritchard, D Mark, Pin, Carmen

Volltext

Cord blood gene expression supports that prenatal exposure to perfluoroalkyl substances causes depressed immune functionality in early childhood von Pennings, Jeroen L. A., Jennen, Danyel G. J., Nygaard, Unni C., Namork, Ellen, Haug, Line S., van Loveren, Henk, Granum, Berit

Volltext

DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds von Hendrickx, Diana M., Souza, Terezinha, Jennen, Danyel G. J., Kleinjans, Jos C. S.

Volltext