The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies von Manry, Jérémy, Bastard, Paul, Gervais, Adrian, Rosain, Jérémie, Philippot, Quentin, Michailidis, Eleftherios, Hoffmann, Hans-Heinrich, Eto, Shohei, Haljasmägi, Liis, Migaud, Mélanie, Särekannu, Karita, Tandjaoui-Lambiotte, Yacine, Gaudet, Alexandre, Poissy, Julien, Morel, Pascal, Richard, Pascale, Saker, Kahina, Gentile, Stéphanie, Shaw, Elana, Morio, Tomohiro, Dalmau, David, Sene, Damien, Stepanian, Alain, Mégarbane, Bruno, Fekkar, Arnaud, Heath, James R, Anaya, Juan-Manuel, Solé-Violán, Jordi, Bonfanti, Paolo, Castagnoli, Riccardo, Delmonte, Ottavia M, Zhang, Yu, Holland, Steven M, Arias, Andrés Augusto, Lorenzo, Lazaro, Planas, Anna M, Duvlis, Sotirija, Bousfiha, Ahmed A, El Bakkouri, Jalila, Paul, Stéphane, Dupont, Annabelle, Kurolap, Alina, Casari, Giorgio, Lampasona, Vito, Barreiros, Lucila A, Dominguez-Garrido, Elena, Vidigal, Mateus, Tancevski, Ivan, Stepanovskyy, Yurii, Nukui, Yoko, Tangye, Stuart G, Burrel, Sonia, Kann, Nelli Y, Coulongeat, Matthieu, Marlet, Julien, Koning, Rutger, Reyes, Luis Felipe, Chauvineau-Grenier, Angélique, Monneret, Guillaume, Arrestier, Romain, Boudhabhay, Idris, Hagin, David, Wauters, Joost, Meyts, Isabelle, Dyer, Adam H, Halwani, Rabih, Dorgham, Karim, Vinh, Donald C, Bondarenko, Anastasiia, Gilardin, Laurent, Bilguvar, Kaya, Mane, Shrikant, Boisson, Bertrand, Béziat, Vivien, Mogensen, Trine H, Rowen, Lee, Mond, James, Debette, Stéphanie, Bouadma, Lila, Colobran, Roger, Gorochov, Guy, Solanich, Xavier, Susen, Sophie, Vasse, Marc, Gregersen, Peter K, Piemonti, Lorenzo, Rodríguez-Gallego, Carlos, Notarangelo, Luigi D, Kisand, Kai, Rice, Charles M, Tiberghien, Pierre, Zhang, Qian, Cobat, Aurélie, COVID Clinicians, [missing], COVID-STORM Clinicians, [missing], NIAID Immune Response to COVID Group, [missing], Danish CHGE, [missing], Danish Blood Donor Study, [missing], St. James's Hospital, SARS CoV2 Interest Group, [missing], French COVID Cohort Study Group, [missing]

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Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths von Bastard, Paul, Le Voyer, Tom, Rosain, Jérémie, Michailidis, Eleftherios, Hoffmann, Hans-Heinrich, Eto, Shohei, Haljasmägi, Liis, Migaud, Mélanie, Särekannu, Karita, Tandjaoui-Lambiotte, Yacine, Gaudet, Alexandre, Poissy, Julien, Morel, Pascal, Richard, Pascale, Troya, Jesus, Saker, Kahina, Gentile, Stéphanie, Shaw, Elana, Morio, Tomohiro, Dalmau, David, Sene, Damien, Stepanian, Alain, Megarbane, Bruno, Fekkar, Arnaud, Heath, James R, Anaya, Juan-Manuel, Solé-Violán, Jordi, Bonfanti, Paolo, Castagnoli, Riccardo, Delmonte, Ottavia M, Zhang, Yu, Holland, Steven M, Arias, Andrés Augusto, Lorenzo, Lazaro, Anglicheau, Dany, Planas, Anna M, Ozcelik, Tayfun, Keles, Sevgi, El Bakkouri, Jalila, Ramirez-Santana, Carolina, Pan-Hammarström, Qiang, Hammarström, Lennart, Metz, Christine N, Aiuti, Alessandro, Casari, Giorgio, Ciceri, Fabio, Vidigal, Mateus, Sahanic, Sabina, Stepanovskyy, Yurii, Tsumura, Miyuki, Duffy, Darragh, Quintana-Murci, Lluis, Kann, Nelli Y, Shcherbina, Anna, Lau, Yu-Lung, Koning, Rutger, Nussenzweig, Michel C, Baris-Feldman, Hagit, Wauters, Joost, Bourke, Nollaig M, Sharif-Askari, Narjes Saheb, Mehlal Sedkaoui, Souad, AlKhater, Suzan, Morandeira, Francisco, Vinh, Donald C, Condino-Neto, Antonio, Spaan, András N, Bilguvar, Kaya, Lifton, Richard P, Anderson, Mark S, Boisson, Bertrand, Zhang, Shen-Ying, Andreakos, Evangelos, Peterson, Pärt, Rowen, Lee, Duval, Xavier, Mentré, France, Zins, Marie, Soler-Palacin, Pere, Susen, Sophie, Martinez-Picado, Javier, Raoult, Didier, Piemonti, Lorenzo, Notarangelo, Luigi D, Okada, Satoshi, Rice, Charles M, Cobat, Aurélie, Abel, Laurent, HGID Lab, [missing], COVID-STORM Clinicians, [missing], NH-COVAIR Study Group, [missing], Danish Blood Donor Study, [missing], French COVID Cohort Study Group, [missing], The Milieu Intérieur Consortium, [missing], CoV-Contact Cohort, [missing], Amsterdam UMC Covid-19 Biobank Investigators, [missing], COVID Human Genetic Effort, [missing], Van Braeckel, Eva, Bosteels, Cedric, Hoste, Eric

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