Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies von Sveen, Anita, Bruun, Jarle, Eide, Peter W, Eilertsen, Ina A, Ramirez, Lorena, Murumägi, Astrid, Arjama, Mariliina, Danielsen, Stine A, Kryeziu, Kushtrim, Elez, Elena, Tabernero, Josep, Guinney, Justin, Palmer, Hector G, Nesbakken, Arild, Kallioniemi, Olli, Dienstmann, Rodrigo, Lothe, Ragnhild A

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Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies von Berg, Kaja C G, Eide, Peter W, Eilertsen, Ina A, Johannessen, Bjarne, Bruun, Jarle, Danielsen, Stine A, Bjørnslett, Merete, Meza-Zepeda, Leonardo A, Eknæs, Mette, Lind, Guro E, Myklebost, Ola, Skotheim, Rolf I, Sveen, Anita, Lothe, Ragnhild A

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CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers von Vedeld, Hege Marie, Merok, Marianne, Jeanmougin, Marine, Danielsen, Stine A., Honne, Hilde, Presthus, Gro Kummeneje, Svindland, Aud, Sjo, Ole H., Hektoen, Merete, Eknæs, Mette, Nesbakken, Arild, Lothe, Ragnhild A., Lind, Guro E.

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Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study von Domingo, Enric, Freeman-Mills, Luke, Rayner, Emily, Glaire, Mark, Briggs, Sarah, Vermeulen, Louis, Fessler, Evelyn, Medema, Jan Paul, Boot, Arnoud, Morreau, Hans, van Wezel, Tom, Liefers, Gerrit-Jan, Lothe, Ragnhild A, Danielsen, Stine A, Sveen, Anita, Nesbakken, Arild, Zlobec, Inti, Lugli, Alessandro, Koelzer, Viktor H, Berger, Martin D, Castellví-Bel, Sergi, Muñoz, Jenifer, de Bruyn, Marco, Nijman, Hans W, Novelli, Marco, Lawson, Kay, Oukrif, Dahmane, Frangou, Eleni, Dutton, Peter, Tejpar, Sabine, Delorenzi, Mauro, Kerr, Rachel, Kerr, David, Tomlinson, Ian, Church, David N

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DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset von Berg, Marianne, Danielsen, Stine A, Ahlquist, Terje, Merok, Marianne A, Ågesen, Trude H, Vatn, Morten H, Mala, Tom, Sjo, Ole H, Bakka, Arne, Moberg, Ingvild, Fetveit, Torunn, Mathisen, Øystein, Husby, Anders, Sandvik, Oddvar, Nesbakken, Arild, Thiis-Evensen, Espen, Lothe, Ragnhild A

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MiR-9, -31, and -182 Deregulation Promote Proliferation and Tumor Cell Survival in Colon Cancer von Cekaite, Lina, Rantala, Juha K, Bruun, Jarle, Guriby, Marianne, Ågesen, Trude H, Danielsen, Stine A, Lind, Guro E, Nesbakken, Arild, Kallioniemi, Olli, Lothe, Ragnhild A, Skotheim, Rolf I

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Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1 von Sveen, Anita, Johannessen, Bjarne, Tengs, Torstein, Danielsen, Stine A, Eilertsen, Ina A, Lind, Guro E, Berg, Kaja C G, Leithe, Edward, Meza-Zepeda, Leonardo A, Domingo, Enric, Myklebost, Ola, Kerr, David, Tomlinson, Ian, Nesbakken, Arild, Skotheim, Rolf I, Lothe, Ragnhild A

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Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas von Lind, Guro E, Danielsen, Stine A, Ahlquist, Terje, Merok, Marianne A, Andresen, Kim, Skotheim, Rolf I, Hektoen, Merete, Rognum, Torleiv O, Meling, Gunn I, Hoff, Geir, Bretthauer, Michael, Thiis-Evensen, Espen, Nesbakken, Arild, Lothe, Ragnhild A

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Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome von Danielsen, Stine A, Cekaite, Lina, Ågesen, Trude H, Sveen, Anita, Nesbakken, Arild, Thiis-Evensen, Espen, Skotheim, Rolf I, Lind, Guro E, Lothe, Ragnhild A

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NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway von Eide, Peter W., Cekaite, Lina, Danielsen, Stine A., Eilertsen, Ina A., Kjenseth, Ane, Fykerud, Tone A., Ågesen, Trude H., Bruun, Jarle, Rivedal, Edgar, Lothe, Ragnhild A., Leithe, Edward

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Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer von Smeby, Jørgen, Sveen, Anita, Eilertsen, Ina A., Danielsen, Stine A., Hoff, Andreas M., Eide, Peter W., Johannessen, Bjarne, Hektoen, Merete, Skotheim, Rolf I., Guren, Marianne G., Nesbakken, Arild, Lothe, Ragnhild A.

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Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon von Burocziova, Monika, Burdova, Kamila, Martinikova, Andra S., Kasparek, Petr, Kleiblova, Petra, Danielsen, Stine A., Borecka, Marianna, Jenikova, Gabriela, Janečková, Lucie, Pavel, Jozef, Zemankova, Petra, Schneiderova, Michaela, Schwarzova, Lucie, Ticha, Ivana, Sun, Xiao-Feng, Jiraskova, Katerina, Liska, Vaclav, Vodickova, Ludmila, Vodicka, Pavel, Sedlacek, Radislav, Kleibl, Zdenek, Lothe, Ragnhild A., Korinek, Vladimír, Macurek, Libor

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Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors von Kolberg, Matthias, Bruun, Jarle, Murumägi, Astrid, Mpindi, John P., Bergsland, Christian H., Høland, Maren, Eilertsen, Ina A., Danielsen, Stine A., Kallioniemi, Olli, Lothe, Ragnhild A.

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Exploratory analyses of consensus molecular subtype-dependent associations of TP53 mutations with immunomodulation and prognosis in colorectal cancer von Smeby, Jørgen, Sveen, Anita, Bergsland, Christian H, Eilertsen, Ina A, Danielsen, Stine A, Eide, Peter W, Hektoen, Merete, Guren, Marianne G, Nesbakken, Arild, Bruun, Jarle, Lothe, Ragnhild A

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Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin von Pinheiro, Manuela, Ahlquist, Terje, Danielsen, Stine A, Lind, Guro E, Veiga, Isabel, Pinto, Carla, Costa, Vera, Afonso, Luís, Sousa, Olga, Fragoso, Maria, Santos, Lúcio, Henrique, Rui, Lopes, Paula, Lopes, Carlos, Lothe, Ragnhild A, Teixeira, Manuel R

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Gene expression profiles of CMS2-epithelial/canonical colorectal cancers are largely driven by DNA copy number gains von Berg, Kaja C. G., Sveen, Anita, Høland, Maren, Alagaratnam, Sharmini, Berg, Marianne, Danielsen, Stine A., Nesbakken, Arild, Søreide, Kjetil, Lothe, Ragnhild A.

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A tissue-based comparative effectiveness analysis of biomarkers for early detection of colorectal tumors von Ahmed, Deeqa, Danielsen, Stine A, Aagesen, Trude H, Bretthauer, Michael, Thiis-Evensen, Espen, Hoff, Geir, Rognum, Torleiv O, Nesbakken, Arild, Lothe, Ragnhild A, Lind, Guro E

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Three Epigenetic Biomarkers, GDF15, TMEFF2, and VIM, Accurately Predict Bladder Cancer from DNA-Based Analyses of Urine Samples von COSTA, Vera L, HENRIQUE, Rui, TEIXEIRA, Manuel R, JERONIMO, Carmen, LIND, Guro E, DANIELSEN, Stine A, DUARTE-PEREIRA, Sara, EKNAES, Mette, SKOTHEIM, Rolf I, RODRIGUES, Angelo, MAGALHAES, José S, OLIVEIRA, Jorge, LOTHE, Ragnhild A

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Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours von Bottillo, Irene, Ahlquist, Terje, Brekke, Helge, Danielsen, Stine A, van den Berg, Eva, Mertens, Fredrik, Lothe, Ragnhild A, Dallapiccola, Bruno

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Abstract 103: Gene expression based subtypes of colorectal cancer von Berg, Kaja G., Eilertsen, Ina A., Alagaratnam, Sharmini, Danielsen, Stine A., Nesbakken, Arild, Sveen, Anita, Lothe, Ragnhild A.

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