HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia von Galbraith, Matthew D., Allen, Mary A., Bensard, Claire L., Wang, Xiaoxing, Schwinn, Marie K., Qin, Bo, Long, Henry W., Daniels, Danette L., Hahn, William C., Dowell, Robin D., Espinosa, Joaquín M.

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Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual... von Zoppi, Vittoria, Hughes, Scott J, Maniaci, Chiara, Testa, Andrea, Gmaschitz, Teresa, Wieshofer, Corinna, Koegl, Manfred, Riching, Kristin M, Daniels, Danette L, Spallarossa, Andrea, Ciulli, Alessio

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KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors von Black, Joshua C., Manning, Amity L., Van Rechem, Capucine, Kim, Jaegil, Ladd, Brendon, Cho, Juok, Pineda, Cristiana M., Murphy, Nancy, Daniels, Danette L., Montagna, Cristina, Lewis, Peter W., Glass, Kimberly, Allis, C. David, Dyson, Nicholas J., Getz, Gad, Whetstine, Johnathan R.

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Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation von Gilan, Omer, Rioja, Inmaculada, Knezevic, Kathy, Bell, Matthew J, Yeung, Miriam M, Harker, Nicola R, Lam, Enid Y N, Chung, Chun-Wa, Bamborough, Paul, Petretich, Massimo, Urh, Marjeta, Atkinson, Stephen J, Bassil, Anna K, Roberts, Emma J, Vassiliadis, Dane, Burr, Marian L, Preston, Alex G S, Wellaway, Christopher, Werner, Thilo, Gray, James R, Michon, Anne-Marie, Gobbetti, Thomas, Kumar, Vinod, Soden, Peter E, Haynes, Andrea, Vappiani, Johanna, Tough, David F, Taylor, Simon, Dawson, Sarah-Jane, Bantscheff, Marcus, Lindon, Matthew, Drewes, Gerard, Demont, Emmanuel H, Daniels, Danette L, Grandi, Paola, Prinjha, Rab K, Dawson, Mark A

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NanoBRETA Novel BRET Platform for the Analysis of Protein–Protein Interactions von Machleidt, Thomas, Woodroofe, Carolyn C, Schwinn, Marie K, Méndez, Jacqui, Robers, Matthew B, Zimmerman, Kris, Otto, Paul, Daniels, Danette L, Kirkland, Thomas A, Wood, Keith V

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TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS von Deplus, Rachel, Delatte, Benjamin, Schwinn, Marie K, Defrance, Matthieu, Méndez, Jacqui, Murphy, Nancy, Dawson, Mark A, Volkmar, Michael, Putmans, Pascale, Calonne, Emilie, Shih, Alan H, Levine, Ross L, Bernard, Olivier, Mercher, Thomas, Solary, Eric, Urh, Marjeta, Daniels, Danette L, Fuks, François

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SONAR Discovers RNA-Binding Proteins from Analysis of Large-Scale Protein-Protein Interactomes von Brannan, Kristopher W., Jin, Wenhao, Huelga, Stephanie C., Banks, Charles A.S., Gilmore, Joshua M., Florens, Laurence, Washburn, Michael P., Van Nostrand, Eric L., Pratt, Gabriel A., Schwinn, Marie K., Daniels, Danette L., Yeo, Gene W.

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Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy von Picaud, Sarah, Fedorov, Oleg, Thanasopoulou, Angeliki, Leonards, Katharina, Jones, Katherine, Meier, Julia, Olzscha, Heidi, Monteiro, Octovia, Martin, Sarah, Philpott, Martin, Tumber, Anthony, Filippakopoulos, Panagis, Yapp, Clarence, Wells, Christopher, Che, Ka Hing, Bannister, Andrew, Robson, Samuel, Kumar, Umesh, Parr, Nigel, Lee, Kevin, Lugo, Dave, Jeffrey, Philip, Taylor, Simon, Vecellio, Matteo L, Bountra, Chas, Brennan, Paul E, O'Mahony, Alison, Velichko, Sharlene, Müller, Susanne, Hay, Duncan, Daniels, Danette L, Urh, Marjeta, La Thangue, Nicholas B, Kouzarides, Tony, Prinjha, Rab, Schwaller, Jürg, Knapp, Stefan

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The TIP60 Complex Is a Conserved Coactivator of HIF1A von Perez-Perri, Joel I., Dengler, Veronica L., Audetat, K. Audrey, Pandey, Ahwan, Bonner, Elizabeth A., Urh, Marjeta, Mendez, Jacqui, Daniels, Danette L., Wappner, Pablo, Galbraith, Matthew D., Espinosa, Joaquín M.

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Hidden modes of DNA binding by human nuclear receptors von Bhimsaria, Devesh, Rodríguez-Martínez, José A., Mendez-Johnson, Jacqui L., Ghoshdastidar, Debostuti, Varadarajan, Ashwin, Bansal, Manju, Daniels, Danette L., Ramanathan, Parameswaran, Ansari, Aseem Z.

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Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes von McGrath, John P, Williamson, Kaylyn E, Balasubramanian, Srividya, Odate, Shobu, Arora, Shilpi, Hatton, Charlie, Edwards, Thomas M, O'Brien, Thomas, Magnuson, Steven, Stokoe, David, Daniels, Danette L, Bryant, Barbara M, Trojer, Patrick

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Potent and selective bivalent inhibitors of BET bromodomains von Waring, Michael J, Chen, Huawei, Rabow, Alfred A, Walker, Graeme, Bobby, Romel, Boiko, Scott, Bradbury, Rob H, Callis, Rowena, Clark, Edwin, Dale, Ian, Daniels, Danette L, Dulak, Austin, Flavell, Liz, Holdgate, Geoff, Jowitt, Thomas A, Kikhney, Alexey, McAlister, Mark, Méndez, Jacqui, Ogg, Derek, Patel, Joe, Petteruti, Philip, Robb, Graeme R, Robers, Matthew B, Saif, Sakina, Stratton, Natalie, Svergun, Dmitri I, Wang, Wenxian, Whittaker, David, Wilson, David M, Yao, Yi

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Structural Studies of Wnts and Identification of an LRP6 Binding Site von Chu, Matthew Ling-Hon, Ahn, Victoria E., Choi, Hee-Jung, Daniels, Danette L., Nusse, Roel, Weis, William I.

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LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor von Clark, Peter G. K., Vieira, Lucas C. C., Tallant, Cynthia, Fedorov, Oleg, Singleton, Dean C., Rogers, Catherine M., Monteiro, Octovia P., Bennett, James M., Baronio, Roberta, Müller, Susanne, Daniels, Danette L., Méndez, Jacqui, Knapp, Stefan, Brennan, Paul E., Dixon, Darren J.

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Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines von Nishiguchi, Gisele, Mascibroda, Lauren G., Young, Sarah M., Caine, Elizabeth A., Abdelhamed, Sherif, Kooijman, Jeffrey J., Miller, Darcie J., Das, Sourav, McGowan, Kevin, Mayasundari, Anand, Shi, Zhe, Barajas, Juan M., Hiltenbrand, Ryan, Aggarwal, Anup, Chang, Yunchao, Mishra, Vibhor, Narina, Shilpa, Thomas, Melvin, Loughran, Allister J., Kalathur, Ravi, Yu, Kaiwen, Zhou, Suiping, Wang, Xusheng, High, Anthony A., Peng, Junmin, Pruett-Miller, Shondra M., Daniels, Danette L., Urh, Marjeta, Shelat, Anang A., Mullighan, Charles G., Riching, Kristin M., Zaman, Guido J. R., Fischer, Marcus, Klco, Jeffery M., Rankovic, Zoran

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9H‑Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain von Picaud, Sarah, Strocchia, Maria, Terracciano, Stefania, Lauro, Gianluigi, Mendez, Jacqui, Daniels, Danette L, Riccio, Raffaele, Bifulco, Giuseppe, Bruno, Ines, Filippakopoulos, Panagis

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Harnessing UBR5 for targeted protein degradation of key transcriptional regulators von Taherbhoy, Asad M., Daniels, Danette L.

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The importance of cellular degradation kinetics for understanding mechanisms in targeted protein degradation von Riching, Kristin M, Caine, Elizabeth A, Urh, Marjeta, Daniels, Danette L

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Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action von Riching, Kristin M, Mahan, Sarah, Corona, Cesear R, McDougall, Mark, Vasta, James D, Robers, Matthew B, Urh, Marjeta, Daniels, Danette L

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Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity von Imaide, Satomi, Riching, Kristin M., Makukhin, Nikolai, Vetma, Vesna, Whitworth, Claire, Hughes, Scott J., Trainor, Nicole, Mahan, Sarah D., Murphy, Nancy, Cowan, Angus D., Chan, Kwok-Ho, Craigon, Conner, Testa, Andrea, Maniaci, Chiara, Urh, Marjeta, Daniels, Danette L., Ciulli, Alessio

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