Total Synthesis of (+)-Dactylolide through an Efficient Sequential Peterson Olefination and Prins Cyclization Reaction von Aubele, Danielle L., Wan, Shuangyi, Floreancig, Paul E.

Volltext

Electron Transfer Initiated Heterogenerative Cascade Cyclizations:  Polyether Synthesis under Nonacidic Conditions von Kumar, V. Satish, Aubele, Danielle L, Floreancig, Paul E

Volltext

Pharmacological inhibition of Polo Like Kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei von Fitzgerald, Kent, Bergeron, Marcelle, Willits, Christopher, Bowers, Simeon, Aubele, Danielle L., Goldbach, Erich, Tonn, George, Ness, Daniel, Olaharski, Andrew

Volltext

Novel cinnoline-based inhibitors of LRRK2 kinase activity von Garofalo, Albert W., Adler, Marc, Aubele, Danielle L., Bowers, Simeon, Franzini, Maurizio, Goldbach, Erich, Lorentzen, Colin, Neitz, R. Jeffrey, Probst, Gary D., Quinn, Kevin P., Santiago, Pam, Sham, Hing L., Tam, Danny, Truong, Anh P., Ye, Xiaocong M., Ren, Zhao

Volltext

Triazolopyridazine LRRK2 kinase inhibitors von Franzini, Maurizio, Ye, Xiaocong M., Adler, Marc, Aubele, Danielle L., Garofalo, Albert W., Gauby, Shawn, Goldbach, Erich, Probst, Gary D., Quinn, Kevin P., Santiago, Pam, Sham, Hing L., Tam, Danny, Truong, Anh, Ren, Zhao

Volltext

Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors von Garofalo, Albert W., Adler, Marc, Aubele, Danielle L., Brigham, Elizabeth F., Chian, David, Franzini, Maurizio, Goldbach, Erich, Kwong, Grace T., Motter, Ruth, Probst, Gary D., Quinn, Kevin P., Ruslim, Lany, Sham, Hing L., Tam, Danny, Tanaka, Pearl, Truong, Anh P., Ye, Xiaocong M., Ren, Zhao

Volltext

Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce [alpha]-Synuclein Phosphorylation in Rat Brain von Aubele, Danielle L, Hom, Roy K, Adler, Marc, Galemmo, Robert A, Bowers, Simeon, Truong, Anh P, Pan, Hu, Beroza, Paul, Neitz, R Jeffrey, Yao, Nanhua, Lin, May, Tonn, George, Zhang, Heather, Bova, Michael P, Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Diep, Linnea, Fitzgerald, Kent, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Dappen, Michael, Jagodzinski, Jacek, Chan, Wayman, Konradi, Andrei W, Latimer, Lee, Zhu, Yong L, Sham, Hing L, Anderson, John P, Bergeron, Marcelle, Artis, Dean R

Volltext

Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce α-Synuclein Phosphorylation in Rat Brain von Aubele, Danielle L., Hom, Roy K., Adler, Marc, Galemmo Jr, Robert A., Bowers, Simeon, Truong, Anh P., Pan, Hu, Beroza, Paul, Neitz, R. Jeffrey, Yao, Nanhua, Lin, May, Tonn, George, Zhang, Heather, Bova, Michael P., Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Diep, Linnea, Fitzgerald, Kent, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Dappen, Michael, Jagodzinski, Jacek, Chan, Wayman, Konradi, Andrei W., Latimer, Lee, Zhu, Yong L., Sham, Hing L., Anderson, John P., Bergeron, Marcelle, Artis, Dean R.

Volltext

Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors von Bowers, Simeon, Truong, Anh P., Ye, Michael, Aubele, Danielle L., Sealy, Jennifer M., Neitz, R. Jeffrey, Hom, Roy K., Chan, Wayman, Dappen, Michael S., Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Zhu, Yong L., Beroza, Paul, Tonn, George, Zhang, Heather, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Bova, Michael P., Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Pandya, Deepal, Diep, Linnea, Fitzgerald, Kent, Artis, Dean R., Anderson, John P., Bergeron, Marcelle

Volltext

Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors von Truong, Anh P., Aubele, Danielle L., Probst, Gary D., Neitzel, Martin L., Semko, Chris M., Bowers, Simeon, Dressen, Darren, Hom, Roy K., Konradi, Andrei W., Sham, Hing L., Garofalo, Albert W., Keim, Pamela S., Wu, Jing, Dappen, Michael S., Wong, Karina, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Nguyen, Lan, Hemphill, Susanna S., Bova, Michael P., Basi, Guriqbal

Volltext

Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors von Ye, Xiaocong M., Konradi, Andrei W., Sun, Minghua, Yuan, Shendong, Aubele, Danielle L., Dappen, Michael, Dressen, Darren, Garofalo, Albert W., Jagodzinski, Jacek J., Latimer, Lee, Probst, Gary D., Sham, Hing L., Wone, David, Xu, Ying-zi, Ness, Daniel, Brigham, Elizabeth, Kwong, Grace T., Willtis, Chris, Tonn, George, Goldbach, Erich, Quinn, Kevin P., Zhang, Hongbin H., Sauer, John-Michael, Bova, Michael, Basi, Guriqbal S.

Volltext

The “Aqueous” Prins Reaction von Aubele, Danielle L, Lee, Christopher A, Floreancig, Paul E

Volltext

A facile synthesis of multigram quantity of ethyl 3-ethylmorpholine-3-carboxylate von Jagodzinski, Jacek J., Aubele, Danielle L., Quincy, David A., Dappen, Michael S., Latimer, Lee H., Hom, Roy K., Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L.

Volltext

Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors von Aubele, Danielle L., Truong, Anh P., Dressen, Darren B., Probst, Gary D., Bowers, Simeon, Mattson, Matthew N., Semko, Chris M., Sun, Minghua, Garofalo, Albert W., Konradi, Andrei W., Sham, Hing L., Zmolek, Wes, Wong, Karina, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Nguyen, Lan, Bova, Michael P., Hemphill, Susanna S., Basi, Guriqbal

Volltext

Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer’s disease von Neitzel, Martin L., Aubele, Danielle L., Marugg, Jennifer L., Jagodzinski, Jacek J., Konradi, Andrei W., Pleiss, Michael A., Szoke, Balazs, Zmolek, Wes, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Bova, Michael P., Hemphill, Susanna, Basi, Guriqbal

Volltext

Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious γ-secretase inhibitors (Part II) von Ye, Xiaocong M., Konradi, Andrei W., Smith, Jenifer, Aubele, Danielle L., Garofalo, Albert W., Marugg, Jennifer, Neitzel, Marty L., Semko, Chris M., Sham, Hing L., Sun, Minghua, Truong, Anh P., Wu, Jing, Zhang, Hongbin, Goldbach, Erich, Sauer, John-Michael, Brigham, Elizabeth F., Bova, Michael, Basi, Guriqbal S.

Volltext

Oxidative Synthesis of Cyclic Acyl Aminals through Carbon−Carbon σ-Bond Activation von Aubele, Danielle L, Floreancig, Paul E

Volltext

Aerobic Organocatalytic Photoinitiated Arene Oxidations:  Application to Electron Transfer Initiated Cyclization Reactions von Kumar, V. Satish, Aubele, Danielle L, Floreancig, Paul E

Volltext

Catalytic Aerobic Generation of Acyliminium Ions through Electron-Transfer-Mediated Carbon-Carbon Bond Activation von Aubele, Danielle L., Rech, Jason C., Floreancig, Paul E.

Volltext

Electron Transfer Initiated Heterogenerative Cascade Cyclizations:  Polyether Synthesis under Nonacidic Conditions von Kumar, V. Satish, Aubele, Danielle L, Floreancig, Paul E

Volltext