Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells von De Henau, Olivier, Rausch, Matthew, Winkler, David, Campesato, Luis Felipe, Liu, Cailian, Cymerman, Daniel Hirschhorn, Budhu, Sadna, Ghosh, Arnab, Pink, Melissa, Tchaicha, Jeremy, Douglas, Mark, Tibbitts, Thomas, Sharma, Sujata, Proctor, Jennifer, Kosmider, Nicole, White, Kerry, Stern, Howard, Soglia, John, Adams, Julian, Palombella, Vito J., McGovern, Karen, Kutok, Jeffery L., Wolchok, Jedd D., Merghoub, Taha

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Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma von Budhu, Sadna, Giese, Rachel, Gupta, Aditi, Fitzgerald, Kelly, Zappasodi, Roberta, Schad, Sara, Hirschhorn, Daniel, Campesato, Luis Felipe, De Henau, Olivier, Gigoux, Mathieu, Liu, Cailian, Mazo, Gregory, Deng, Liang, Barker, Christopher A., Wolchok, Jedd D., Merghoub, Taha

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Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation von Cohen, Adam D, Schaer, David A, Liu, Cailian, Li, Yanyun, Hirschhorn-Cymmerman, Daniel, Kim, Soo Chong, Diab, Adi, Rizzuto, Gabrielle, Duan, Fei, Perales, Miguel A, Merghoub, Taha, Houghton, Alan N, Wolchok, Jedd D

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Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy von Schaer, David A, Hirschhorn-Cymerman, Daniel, Wolchok, Jedd D

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TYRP1 directed CAR T cells control tumor progression in preclinical melanoma models von Hackett, Christopher S, Hirschhorn, Daniel, Tang, Meixian S, Purdon, Terence J, Marouf, Yacine, Piersigilli, Alessandra, Agaram, Narasimhan P, Liu, Cailian, Schad, Sara E, de Stanchina, Elisa, Rafiq, Sarwish, Monette, Sebastien, Wolchok, Jedd D, Merghoub, Taha, Brentjens, Renier J

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Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs von Nakahara, Takeshi, Uchi, Hiroshi, Lesokhin, Alexander M., Avogadri, Francesca, Rizzuto, Gabrielle A., Hirschhorn-Cymerman, Daniel, Panageas, Katherine S., Merghoub, Taha, Wolchok, Jedd D., Houghton, Alan N.

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878 T cell immunotherapies recruit and activate neutrophils to eliminate tumor antigen escape variants von Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M, Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B, Li, Yanyun, Flamar, Anne-Laure, Choi, Heyjin, Cortez, Czrina A, Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Hamadene, Linda, Warner, Allison Betof, Hollmann, Travis, Arora, Arshi, Panageas, Katherine S, Duhen, Rebekka, Weinberg, Andrew D, Rizzuto, Gabrielle A, Spencer, Christine N, Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D, Merghoub, Taha

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Having the cake and eating it? Clofazimine boosts immunotherapy while limiting side effects von Kraehenbuehl, Lukas, Wolchok, Jedd D, Merghoub, Taha, Hirschhorn, Daniel

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Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness von Hirschhorn, Daniel, Betof Warner, Allison, Maniyar, Rachana, Chow, Andrew, Mangarin, Levi Mb, Cohen, Adam D, Hamadene, Linda, Rizzuto, Gabrielle A, Budhu, Sadna, Suek, Nathan, Liu, Cailian, Houghton, Alan N, Merghoub, Taha, Wolchok, Jedd D

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99 T cell immunotherapies trigger neutrophil activation to eliminate tumor antigen escape variants von Hirschhorn, Daniel, Budhu, Sadna, Schröder, David, kraehenbuehl, Lukas, Flammar, Anne-Laurent, Chow, Andrew, Schulze, Isabell, Schad, Sara, Ricca, Jacob, Gasmi, Billel, Henau, Olivier De, Mangarin, Levi, Redmond, David, Cortez, Czrina, Liu, Cailian, Holland, Aliya, Gigoux, Mathieu, Arora, Asrhi, Panageas, Katherine, Rizzuto, Gabrielle, Albrengues, Jean, Egeblad, Mikala, Wolchok, Jedd, Merghoub, Taha

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Alphavirus replicon particles expressing TRP-2 provide potent therapeutic effect on melanoma through activation of humoral and cellular immunity von Avogadri, Francesca, Merghoub, Taha, Maughan, Maureen F, Hirschhorn-Cymerman, Daniel, Morris, John, Ritter, Erika, Olmsted, Robert, Houghton, Alan N, Wolchok, Jedd D

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Glucocorticoid-Induced TNF Receptor Family Related Gene Activation Overcomes Tolerance/Ignorance to Melanoma Differentiation Antigens and Enhances Antitumor Immunity von Ramirez-Montagut, Teresa, Chow, Andrew, Hirschhorn-Cymerman, Daniel, Terwey, Theis H, Kochman, Adam A, Lu, Sydney, Miles, Randy C, Sakaguchi, Shimon, Houghton, Alan N, van den Brink, Marcel R. M

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Overcoming resistance to checkpoint blockade therapy by targeting PI3K in myeloid cells von De Henau, Olivier, Rausch, Matthew, Winkler, David, Campesato, Luis Felipe, Liu, Cailian, Cymerman, Daniel Hirschhorn, Budhu, Sadna, Ghosh, Arnab, Pink, Melissa, Tchaicha, Jeremy, Douglas, Mark, Tibbitts, Thomas, Sharma, Sujata, Proctor, Jennifer, Kosmider, Nicole, White, Kerry, Stern, Howard, Soglia, John, Adams, Julian, Palombella, Vito J, McGovern, Karen, Kutok, Jeffery L, Wolchok, Jedd D, Merghoub, Taha

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Having the cake and eating it? Clofazimine boosts immunotherapy while limiting side effects von Kraehenbuehl, Lukas, Wolchok, Jedd D., Merghoub, Taha, Hirschhorn, Daniel

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T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants von Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M., Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B., Li, Yanyun, Hamadene, Linda, Flamar, Anne-Laure, Choi, Hyejin, Cortez, Czrina A., Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Betof Warner, Allison, Hollmann, Travis J., Arora, Arshi, Panageas, Katherine S., Rizzuto, Gabrielle A., Duhen, Rebekka, Weinberg, Andrew D., Spencer, Christine N., Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D., Merghoub, Taha

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549 Characterizing double positive T cells in the tumor microenvironment: a tale of promiscuous cell fates von Schad, Sara, Chow, Andrew, Pan, Heng, Mangarin, Levi, Zappasodi, Roberta, Gigoux, Mathieu, Redmond, David, Hirschhorn-Cymerman, Daniel, Budhu, Sadna, Zhong, Hong, Yang, Xia, Elemento, Olivier, Wolchok, Jedd, Merghoub, Taha

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The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer von Chow, Andrew, Uddin, Fathema Z., Liu, Michael, Dobrin, Anton, Nabet, Barzin Y., Mangarin, Levi, Lavin, Yonit, Rizvi, Hira, Tischfield, Sam E., Quintanal-Villalonga, Alvaro, Chan, Joseph M., Shah, Nisargbhai, Allaj, Viola, Manoj, Parvathy, Mattar, Marissa, Meneses, Maximiliano, Landau, Rebecca, Ward, Mariana, Kulick, Amanda, Kwong, Charlene, Wierzbicki, Matthew, Yavner, Jessica, Egger, Jacklynn, Chavan, Shweta S., Farillas, Abigail, Holland, Aliya, Sridhar, Harsha, Ciampricotti, Metamia, Hirschhorn, Daniel, Guan, Xiangnan, Richards, Allison L., Heller, Glenn, Mansilla-Soto, Jorge, Sadelain, Michel, Klebanoff, Christopher A., Hellmann, Matthew D., Sen, Triparna, de Stanchina, Elisa, Wolchok, Jedd D., Merghoub, Taha, Rudin, Charles M.

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Abstract 1795: Combination of cyclophosphamide chemotherapy with immune modulation overcomes resistance to checkpoint blockade in a pre-clinical melanoma model von Warner, Allison Betof, Hirschhorn, Daniel, Mangarin, Levi M., Hamadene, Linda, Cohen, Adam D., Rizzuto, Gabrielle A., Wolchok, Jedd D., Merghoub, Taha

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Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions von Schad, Sara E, Chow, Andrew, Mangarin, Levi, Pan, Heng, Zhang, Jiajia, Ceglia, Nicholas, Caushi, Justina X, Malandro, Nicole, Zappasodi, Roberta, Gigoux, Mathieu, Hirschhorn, Daniel, Budhu, Sadna, Amisaki, Masataka, Arniella, Monica, Redmond, David, Chaft, Jamie, Forde, Patrick M, Gainor, Justin F, Hellmann, Matthew D, Balachandran, Vinod, Shah, Sohrab, Smith, Kellie N, Pardoll, Drew, Elemento, Olivier, Wolchok, Jedd D, Merghoub, Taha

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In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors von Khalil, Danny N, Suek, Nathan, Campesato, Luis Felipe, Budhu, Sadna, Redmond, David, Samstein, Robert M, Krishna, Chirag, Panageas, Katherine S, Capanu, Marinela, Houghton, Sean, Hirschhorn, Daniel, Zappasodi, Roberta, Giese, Rachel, Gasmi, Billel, Schneider, Michael, Gupta, Aditi, Harding, James J, Moral, John Alec, Balachandran, Vinod P, Wolchok, Jedd D, Merghoub, Taha

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