Polygenic basis and biomedical consequences of telomere length variation von Codd, Veryan, Wang, Qingning, Allara, Elias, Musicha, Crispin, Kaptoge, Stephen, Stoma, Svetlana, Jiang, Tao, Hamby, Stephen E., Braund, Peter S., Bountziouka, Vasiliki, Budgeon, Charley A., Denniff, Matthew, Swinfield, Chloe, Papakonstantinou, Manolo, Sheth, Shilpi, Nanus, Dominika E., Warner, Sophie C., Wang, Minxian, Khera, Amit V., Eales, James, Ouwehand, Willem H., Thompson, John R., Di Angelantonio, Emanuele, Wood, Angela M., Butterworth, Adam S., Danesh, John N., Nelson, Christopher P., Samani, Nilesh J.

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Interpretation of the evidence for the efficacy and safety of statin therapy von Collins, Rory, Prof, Reith, Christina, FRCP (Glasg.), Emberson, Jonathan, PhD, Armitage, Jane, Prof, Baigent, Colin, Prof, Blackwell, Lisa, BSc, Blumenthal, Roger, Prof, Danesh, John, Prof, Smith, George Davey, Prof, DeMets, David, Prof, Evans, Stephen, Prof, Law, Malcolm, Prof, MacMahon, Stephen, Prof, Martin, Seth, MD, Neal, Bruce, Prof, Poulter, Neil, Prof, Preiss, David, PhD, Ridker, Paul, Prof, Roberts, Ian, Prof, Rodgers, Anthony, Prof, Sandercock, Peter, Prof, Schulz, Kenneth, Prof, Sever, Peter, Prof, Simes, John, Prof, Smeeth, Liam, Prof, Wald, Nicholas, Prof, Yusuf, Salim, Prof, Peto, Richard, Prof

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PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations von Kamat, Mihir A, Blackshaw, James A, Young, Robin, Surendran, Praveen, Burgess, Stephen, Danesh, John, Butterworth, Adam S, Staley, James R

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Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study von Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam S., Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kuehn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjonneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C., Menendez, Virginia, Agudo, Antonio, Sanchez, Maria-Jose, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio Barricarte, Tong, Tammy Y. N., Schmidt, Julie A., Tzoulaki, Ioanna, Tsilidis, Konstantinos K., Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Picavet, H. Susan J., Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Jenab, Mazda, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick J., Gunter, Marc J., Ferrari, Pietro

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ANGPTL3 Deficiency and Protection Against Coronary Artery Disease von Stitziel, Nathan O., MD, PhD, Khera, Amit V., MD, Wang, Xiao, PhD, Bierhals, Andrew J., MD, MPH, Vourakis, A. Christina, BA, Sperry, Alexandra E., BA, Natarajan, Pradeep, MD, Klarin, Derek, MD, Emdin, Connor A., DPhil, Zekavat, Seyedeh M., BSc, Nomura, Akihiro, MD, Erdmann, Jeanette, PhD, Schunkert, Heribert, MD, Samani, Nilesh J., MD, Kraus, William E., MD, Shah, Svati H., MD, MPH, Yu, Bing, PhD, Boerwinkle, Eric, PhD, Rader, Daniel J., MD, Gupta, Namrata, PhD, Frossard, Philippe M., PhD, Rasheed, Asif, MBBS, Danesh, John, DPhil, Lander, Eric S., PhD, Gabriel, Stacey, PhD, Saleheen, Danish, MBBS, PhD, Musunuru, Kiran, MD, PhD, MPH, Kathiresan, Sekar, MD

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Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease von Jaiswal, Siddhartha, Natarajan, Pradeep, Silver, Alexander J, Gibson, Christopher J, Bick, Alexander G, Shvartz, Eugenia, McConkey, Marie, Gupta, Namrata, Gabriel, Stacey, Ardissino, Diego, Baber, Usman, Mehran, Roxana, Fuster, Valentin, Danesh, John, Frossard, Philippe, Saleheen, Danish, Melander, Olle, Sukhova, Galina K, Neuberg, Donna, Libby, Peter, Kathiresan, Sekar, Ebert, Benjamin L

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The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation von Lambert, Samuel A., Gil, Laurent, Jupp, Simon, Ritchie, Scott C., Xu, Yu, Buniello, Annalisa, McMahon, Aoife, Abraham, Gad, Chapman, Michael, Parkinson, Helen, Danesh, John, MacArthur, Jacqueline A. L., Inouye, Michael

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PhenoScanner: a database of human genotype-phenotype associations von Staley, James R, Blackshaw, James, Kamat, Mihir A, Ellis, Steve, Surendran, Praveen, Sun, Benjamin B, Paul, Dirk S, Freitag, Daniel, Burgess, Stephen, Danesh, John, Young, Robin, Butterworth, Adam S

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Mendelian Randomization Study of ACLY and Cardiovascular Disease von Ference, Brian A, Ray, Kausik K, Catapano, Alberico L, Ference, Thatcher B, Burgess, Stephen, Neff, David R, Oliver-Williams, Clare, Wood, Angela M, Butterworth, Adam S, Di Angelantonio, Emanuele, Danesh, John, Kastelein, John J.P, Nicholls, Stephen J

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Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents von Di Angelantonio, Emanuele, Bhupathiraju, Shilpa N, Wormser, David, Gao, Pei, Kaptoge, Stephen, de Gonzalez, Amy Berrington, Cairns, Benjamin J, Huxley, Rachel, Jackson, Chandra L, Joshy, Grace, Lewington, Sarah, Manson, JoAnn E, Murphy, Neil, Patel, Alpa V, Samet, Jonathan M, Woodward, Mark, Zheng, Wei, Zhou, Maigen, Bansal, Narinder, Barricarte, Aurelio, Carter, Brian, Cerhan, James R, Collins, Rory, Smith, George Davey, Fang, Xianghua, Franco, Oscar H, Green, Jane, Halsey, Jim, Hildebrand, Janet S, Jung, Keum Ji, Korda, Rosemary J, McLerran, Dale F, Moore, Steven C, O'Keeffe, Linda M, Paige, Ellie, Ramond, Anna, Reeves, Gillian K, Rolland, Betsy, Sacerdote, Carlotta, Sattar, Naveed, Sofianopoulou, Eleni, Stevens, June, Thun, Michael, Ueshima, Hirotsugu, Yang, Ling, Yun, Young Duk, Willeit, Peter, Banks, Emily, Beral, Valerie, Chen, Zhengming, Gapstur, Susan M, Gunter, Marc J, Hartge, Patricia, Jee, Sun Ha, Lam, Tai-Hing, Peto, Richard, Potter, John D, Willett, Walter C, Thompson, Simon G, Danesh, John, Hu, Frank B

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Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels von Emdin, Connor A., DPhil, Khera, Amit V., MD, Natarajan, Pradeep, MD, Klarin, Derek, MD, Won, Hong-Hee, PhD, Peloso, Gina M., PhD, Stitziel, Nathan O., MD, PhD, Nomura, Akihiro, MD, Zekavat, Seyedeh M., BSc, Bick, Alexander G., MD, Gupta, Namrata, PhD, Asselta, Rosanna, PhD, Duga, Stefano, PhD, Merlini, Piera Angelica, MD, Correa, Adolfo, MD, Kessler, Thorsten, MD, Wilson, James G., MD, Bown, Matthew J., MD, Hall, Alistair S., MD, Braund, Peter S., PhD, Samani, Nilesh J., MD, Schunkert, Heribert, MD, Marrugat, Jaume, MD, PhD, Elosua, Roberto, MD, PhD, McPherson, Ruth, MD, Farrall, Martin, PhD, Watkins, Hugh, MD, PhD, Willer, Cristen, PhD, Abecasis, Gonçalo R., PhD, Felix, Janine F., MD, PhD, Vasan, Ramachandran S., MD, Lander, Eric, PhD, Rader, Daniel J., MD, Danesh, John, MSc, DPhil, Ardissino, Diego, MD, Gabriel, Stacey, PhD, Saleheen, Danish, MD, Kathiresan, Sekar, MD

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The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease von Astle, William J., Elding, Heather, Jiang, Tao, Allen, Dave, Ruklisa, Dace, Mann, Alice L., Mead, Daniel, Bouman, Heleen, Riveros-Mckay, Fernando, Kostadima, Myrto A., Lambourne, John J., Sivapalaratnam, Suthesh, Downes, Kate, Kundu, Kousik, Bomba, Lorenzo, Berentsen, Kim, Bradley, John R., Daugherty, Louise C., Delaneau, Olivier, Freson, Kathleen, Garner, Stephen F., Grassi, Luigi, Guerrero, Jose, Haimel, Matthias, Janssen-Megens, Eva M., Kaan, Anita, Kamat, Mihir, Kim, Bowon, Mandoli, Amit, Marchini, Jonathan, Martens, Joost H.A., Meacham, Stuart, Megy, Karyn, O’Connell, Jared, Petersen, Romina, Sharifi, Nilofar, Sheard, Simon M., Staley, James R., Tuna, Salih, van der Ent, Martijn, Walter, Klaudia, Wang, Shuang-Yin, Wheeler, Eleanor, Wilder, Steven P., Iotchkova, Valentina, Moore, Carmel, Sambrook, Jennifer, Stunnenberg, Hendrik G., Di Angelantonio, Emanuele, Kaptoge, Stephen, Kuijpers, Taco W., Carrillo-de-Santa-Pau, Enrique, Juan, David, Rico, Daniel, Valencia, Alfonso, Chen, Lu, Ge, Bing, Vasquez, Louella, Kwan, Tony, Garrido-Martín, Diego, Watt, Stephen, Yang, Ying, Guigo, Roderic, Beck, Stephan, Paul, Dirk S., Pastinen, Tomi, Bujold, David, Bourque, Guillaume, Frontini, Mattia, Danesh, John, Roberts, David J., Ouwehand, Willem H., Butterworth, Adam S., Soranzo, Nicole

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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases von Zheng, Jie, Haberland, Valeriia, Baird, Denis, Walker, Venexia, Haycock, Philip C., Hurle, Mark R., Gutteridge, Alex, Erola, Pau, Liu, Yi, Luo, Shan, Robinson, Jamie, Richardson, Tom G., Staley, James R., Elsworth, Benjamin, Burgess, Stephen, Sun, Benjamin B., Danesh, John, Runz, Heiko, Maranville, Joseph C., Martin, Hannah M., Yarmolinsky, James, Laurin, Charles, Holmes, Michael V., Liu, Jimmy Z., Estrada, Karol, Santos, Rita, McCarthy, Linda, Waterworth, Dawn, Nelson, Matthew R., Smith, George Davey, Butterworth, Adam S., Hemani, Gibran, Scott, Robert A., Gaunt, Tom R.

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Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke von Abraham, Gad, Malik, Rainer, Yonova-Doing, Ekaterina, Salim, Agus, Wang, Tingting, Danesh, John, Butterworth, Adam S., Howson, Joanna M. M., Inouye, Michael, Dichgans, Martin

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Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program von Klarin, Derek, Damrauer, Scott M., Cho, Kelly, Sun, Yan V., Teslovich, Tanya M., Honerlaw, Jacqueline, Gagnon, David R., DuVall, Scott L., Li, Jin, Peloso, Gina M., Chaffin, Mark, Small, Aeron M., Huang, Jie, Tang, Hua, Lynch, Julie A., Ho, Yuk-Lam, Liu, Dajiang J., Emdin, Connor A., Li, Alexander H., Huffman, Jennifer E., Lee, Jennifer S., Natarajan, Pradeep, Chowdhury, Rajiv, Saleheen, Danish, Vujkovic, Marijana, Baras, Aris, Pyarajan, Saiju, Di Angelantonio, Emanuele, Neale, Benjamin M., Naheed, Aliya, Khera, Amit V., Danesh, John, Chang, Kyong-Mi, Abecasis, Gonçalo, Willer, Cristen, Dewey, Frederick E., Carey, David J., Concato, John, Gaziano, J. Michael, O’Donnell, Christopher J., Tsao, Philip S., Kathiresan, Sekar, Rader, Daniel J., Wilson, Peter W. F., Assimes, Themistocles L.

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Association Between Depressive Symptoms and Incident Cardiovascular Diseases von Harshfield, Eric L, Pennells, Lisa, Schwartz, Joseph E, Willeit, Peter, Kaptoge, Stephen, Bell, Steven, Shaffer, Jonathan A, Bolton, Thomas, Spackman, Sarah, Wassertheil-Smoller, Sylvia, Kee, Frank, Amouyel, Philippe, Shea, Steven J, Kuller, Lewis H, Kauhanen, Jussi, van Zutphen, E. M, Blazer, Dan G, Krumholz, Harlan, Nietert, Paul J, Kromhout, Daan, Laughlin, Gail, Berkman, Lisa, Wallace, Robert B, Simons, Leon A, Dennison, Elaine M, Barr, Elizabeth L. M, Meyer, Haakon E, Wood, Angela M, Danesh, John, Di Angelantonio, Emanuele, Davidson, Karina W

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Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease von Yao, Chen, Chen, George, Song, Ci, Keefe, Joshua, Mendelson, Michael, Huan, Tianxiao, Sun, Benjamin B., Laser, Annika, Maranville, Joseph C., Wu, Hongsheng, Ho, Jennifer E., Courchesne, Paul, Lyass, Asya, Larson, Martin G., Gieger, Christian, Graumann, Johannes, Johnson, Andrew D., Danesh, John, Runz, Heiko, Hwang, Shih-Jen, Liu, Chunyu, Butterworth, Adam S., Suhre, Karsten, Levy, Daniel

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Big data from electronic health records for early and late translational cardiovascular research: challenges and potential von Hemingway, Harry, Asselbergs, Folkert W, Danesh, John, Dobson, Richard, Maniadakis, Nikolaos, Maggioni, Aldo, van Thiel, Ghislaine J M, Cronin, Maureen, Brobert, Gunnar, Vardas, Panos, Anker, Stefan D, Grobbee, Diederick E, Denaxas, Spiros

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Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses von Sun, Luanluan, Pennells, Lisa, Kaptoge, Stephen, Nelson, Christopher P., Ritchie, Scott C., Abraham, Gad, Arnold, Matthew, Bell, Steven, Bolton, Thomas, Burgess, Stephen, Dudbridge, Frank, Guo, Qi, Sofianopoulou, Eleni, Stevens, David, Thompson, John R., Butterworth, Adam S., Wood, Angela, Danesh, John, Samani, Nilesh J., Inouye, Michael, Di Angelantonio, Emanuele

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A cross-platform approach identifies genetic regulators of human metabolism and health von Lotta, Luca A., Pietzner, Maik, Stewart, Isobel D., Wittemans, Laura B. L., Li, Chen, Bonelli, Roberto, Raffler, Johannes, Biggs, Emma K., Oliver-Williams, Clare, Auyeung, Victoria P. W., Luan, Jian’an, Wheeler, Eleanor, Paige, Ellie, Surendran, Praveen, Michelotti, Gregory A., Scott, Robert A., Burgess, Stephen, Zuber, Verena, Sanderson, Eleanor, Koulman, Albert, Imamura, Fumiaki, Forouhi, Nita G., Khaw, Kay-Tee, Griffin, Julian L., Wood, Angela M., Kastenmüller, Gabi, Danesh, John, Butterworth, Adam S., Gribble, Fiona M., Reimann, Frank, Bahlo, Melanie, Fauman, Eric, Wareham, Nicholas J., Langenberg, Claudia

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