Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells von Hosios, Aaron M., Hecht, Vivian C., Danai, Laura V., Johnson, Marc O., Rathmell, Jeffrey C., Steinhauser, Matthew L., Manalis, Scott R., Vander Heiden, Matthew G.

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Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability von Sullivan, Mark R, Danai, Laura V, Lewis, Caroline A, Chan, Sze Ham, Gui, Dan Y, Kunchok, Tenzin, Dennstedt, Emily A, Vander Heiden, Matthew G, Muir, Alexander

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mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient von Wyant, Gregory A., Abu-Remaileh, Monther, Wolfson, Rachel L., Chen, Walter W., Freinkman, Elizaveta, Danai, Laura V., Vander Heiden, Matthew G., Sabatini, David M.

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Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies von Muir, Alexander, Danai, Laura V, Vander Heiden, Matthew G

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Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition von Muir, Alexander, Danai, Laura V, Gui, Dan Y, Waingarten, Chiara Y, Lewis, Caroline A, Vander Heiden, Matthew G

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Aspartate is an endogenous metabolic limitation for tumour growth von Sullivan, Lucas B., Luengo, Alba, Danai, Laura V., Bush, Lauren N., Diehl, Frances F., Hosios, Aaron M., Lau, Allison N., Elmiligy, Sarah, Malstrom, Scott, Lewis, Caroline A., Vander Heiden, Matthew G.

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The Conserved Misshapen-Warts-Yorkie Pathway Acts in Enteroblasts to Regulate Intestinal Stem Cells in Drosophila von Li, Qi, Li, Shuangxi, Mana-Capelli, Sebastian, Roth Flach, Rachel J., Danai, Laura V., Amcheslavsky, Alla, Nie, Yingchao, Kaneko, Satoshi, Yao, Xiaohao, Chen, Xiaochu, Cotton, Jennifer L., Mao, Junhao, McCollum, Dannel, Jiang, Jin, Czech, Michael P., Xu, Lan, Ip, Y. Tony

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Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma von Lau, Allison N., Li, Zhaoqi, Danai, Laura, Westermark, Anna M., Darnell, Alicia M., Ferreira, Raphael, Gocheva, Vasilena, Sivanand, Sharanya, Lien, Evan C., Sapp, Kiera M., Mayers, Jared R., Biffi, Giulia, Chin, Christopher R., Davidson, Shawn M., Tuveson, David A., Jacks, Tyler, Matheson, Nicholas J., Yilmaz, Omer, Vander Heiden, Matthew G.

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Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers von Mayers, Jared R., Torrence, Margaret E., Danai, Laura V., Papagiannakopoulos, Thales, Davidson, Shawn M., Bauer, Matthew R., Lau, Allison N., Ji, Brian W., Dixit, Purushottam D., Hosios, Aaron M., Muir, Alexander, Chin, Christopher R., Freinkman, Elizaveta, Jacks, Tyler, Wolpin, Brian M., Vitkup, Dennis, Vander Heiden, Matthew G.

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Altered exocrine function can drive adipose wasting in early pancreatic cancer von Danai, Laura V., Babic, Ana, Rosenthal, Michael H., Dennstedt, Emily A., Muir, Alexander, Lien, Evan C., Mayers, Jared R., Tai, Karen, Lau, Allison N., Jones-Sali, Paul, Prado, Carla M., Petersen, Gloria M., Takahashi, Naoki, Sugimoto, Motokazu, Yeh, Jen Jen, Lopez, Nicole, Bardeesy, Nabeel, Fernandez-del Castillo, Carlos, Liss, Andrew S., Koong, Albert C., Bui, Justin, Yuan, Chen, Welch, Marisa W., Brais, Lauren K., Kulke, Matthew H., Dennis, Courtney, Clish, Clary B., Wolpin, Brian M., Vander Heiden, Matthew G.

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Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis von Roth Flach, Rachel J., Skoura, Athanasia, Matevossian, Anouch, Danai, Laura V., Zheng, Wei, Cortes, Christian, Bhattacharya, Samit K., Aouadi, Myriam, Hagan, Nana, Yawe, Joseph C., Vangala, Pranitha, Menendez, Lorena Garcia, Cooper, Marcus P., Fitzgibbons, Timothy P., Buckbinder, Leonard, Czech, Michael P.

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A major role of insulin in promoting obesity-associated adipose tissue inflammation von Pedersen, David J, Guilherme, Adilson, Danai, Laura V, Heyda, Lauren, Matevossian, Anouch, Cohen, Jessica, Nicoloro, Sarah M, Straubhaar, Juerg, Noh, Hye Lim, Jung, DaeYoung, Kim, Jason K, Czech, Michael P

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The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis von DiStefano, Marina T., Danai, Laura V., Roth Flach, Rachel J., Chawla, Anil, Pedersen, David J., Guilherme, Adilson, Czech, Michael P.

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Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer von Babic, Ana, Rosenthal, Michael H, Bamlet, William R, Takahashi, Naoki, Sugimoto, Motokazu, Danai, Laura V, Morales-Oyarvide, Vicente, Khalaf, Natalia, Dunne, Richard F, Brais, Lauren K, Welch, Marisa W, Zellers, Caitlin L, Dennis, Courtney, Rifai, Nader, Prado, Carla M, Caan, Bette, Sundaresan, Tilak K, Meyerhardt, Jeffrey A, Kulke, Matthew H, Clish, Clary B, Ng, Kimmie, Vander Heiden, Matthew G, Petersen, Gloria M, Wolpin, Brian M

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Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming von Guilherme, Adilson, Pedersen, David J, Henchey, Elizabeth, Henriques, Felipe S, Danai, Laura V, Shen, Yuefei, Yenilmez, Batuhan, Jung, DaeYoung, Kim, Jason K, Lodhi, Irfan J, Semenkovich, Clay F, Czech, Michael P

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Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling[S] von Danai, Laura V., Guilherme, Adilson, Guntur, Kalyani V., Straubhaar, Juerg, Nicoloro, Sarah M., Czech, Michael P.

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Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues von Danai, Laura V., Roth Flach, Rachel J., Virbasius, Joseph V., Garcia Menendez, Lorena, Jung, Dae Young, Kim, Jong Hun, Kim, Jason K., Czech, Michael P.

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Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia von Roth Flach, Rachel J., Danai, Laura V., DiStefano, Marina T., Kelly, Mark, Menendez, Lorena Garcia, Jurczyk, Agata, Sharma, Rohit B., Jung, Dae Young, Kim, Jong Hun, Kim, Jason K., Bortell, Rita, Alonso, Laura C., Czech, Michael P.

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Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function von Roth Flach, Rachel J., Guo, Chang-An, Danai, Laura V., Yawe, Joseph C., Gujja, Sharvari, Edwards, Yvonne J. K., Czech, Michael P.

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PKM2 is not required for pancreatic ductal adenocarcinoma von Hillis, Alissandra L, Lau, Allison N, Devoe, Camille X, Dayton, Talya L, Danai, Laura V, Di Vizio, Dolores, Vander Heiden, Matthew G

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