Ethanol exposure drives colon location specific cell composition changes in a normal colon crypt 3D organoid model von Devall, Matthew, Plummer, Sarah J., Bryant, Jennifer, Jennelle, Lucas T., Eaton, Stephen, Dampier, Christopher H., Huyghe, Jeroen R., Peters, Ulrike, Powell, Steven M., Casey, Graham

Volltext

A functional variant on 20q13.33 related to glioma risk alters enhancer activity and modulates expression of multiple genes von Ali, Mourad Wagdy, Patro, C. Pawan K., Zhu, Jacqueline Jufen, Dampier, Christopher H., Plummer, Sarah J., Kuscu, Cem, Adli, Mazhar, Lau, Ching, Lai, Rose K., Casey, Graham

Volltext

A Functional Variant on 9p21.3 Related to Glioma Risk Affects Enhancer Activity and Modulates Expression of CDKN2B‐AS1 von Ali, Mourad Wagdy, Patro, C. Pawan K., Devall, Matthew, Dampier, Christopher H., Plummer, Sarah J., Kuscu, Cem, Adli, Mazhar, Lai, Rose K., Casey, Graham

Volltext

DNA methylation analysis of normal colon organoids from familial adenomatous polyposis patients reveals novel insight into colon cancer development von Devall, Matthew A, Eaton, Stephen, Ali, Mourad Wagdy, Dampier, Christopher H, Weisenberger, Daniel, Powell, Steven M, Li, Li, Casey, Graham

Volltext

Transcriptome-wide In Vitro Effects of Aspirin on Patient-derived Normal Colon Organoids von Devall, Matthew A. M., Drew, David A., Dampier, Christopher H., Plummer, Sarah J., Eaton, Stephen, Bryant, Jennifer, Diez-Obrero, Virginia, Mo, Jiancheng, Kedrin, Dmitriy, Zerjav, Dylan C., Takacsi-Nagy, Oliver, Jennelle, Lucas T., Ali, Mourad W., Yilmaz, Omer H., Moreno, Victor, Powell, Steven M., Chan, Andrew T., Peters, Ulrike, Casey, Graham

Volltext

Transcriptomic Response to Calcium in Normal Colon Organoids is Impacted by Colon Location and Sex von Devall, Matthew A M, Dampier, Christopher H, Eaton, Stephen, Ali, Mourad Wagdy, Plummer, Sarah J, Bryant, Jennifer, Gauderman, W James, Peters, Ulrike, Powell, Steven M, Casey, Graham

Volltext

Colon Crypts of Subjects With Familial Adenomatous Polyposis Show an Increased Number of LGR5+ Ectopic Stem Cells von Jennelle, Lucas T., Dampier, Christopher H., Tring, Stephanie, Powell, Steven, Casey, Graham

Volltext

Novel insights into the molecular mechanisms underlying risk of colorectal cancer from smoking and red/processed meat carcinogens by modeling exposure in normal colon organoids von Devall, Matthew, Dampier, Christopher H., Eaton, Stephen, Ali, Mourad W., Díez-Obrero, Virginia, Moratalla-Navarro, Ferran, Bryant, Jennifer, Jennelle, Lucas T., Moreno, Victor, Powell, Steven M., Peters, Ulrike, Casey, Graham

Volltext

Genetic Effects on Transcriptome Profiles in Colon Epithelium Provide Functional Insights for Genetic Risk Loci von Díez-Obrero, Virginia, Dampier, Christopher H., Moratalla-Navarro, Ferran, Devall, Matthew, Plummer, Sarah J., Díez-Villanueva, Anna, Peters, Ulrike, Bien, Stephanie, Huyghe, Jeroen R., Kundaje, Anshul, Ibáñez-Sanz, Gemma, Guinó, Elisabeth, Obón-Santacana, Mireia, Carreras-Torres, Robert, Casey, Graham, Moreno, Víctor

Volltext

Oncogenic Features in Histologically Normal Mucosa: Novel Insights Into Field Effect From a Mega-Analysis of Colorectal Transcriptomes von Dampier, Christopher H., Devall, Matthew, Jennelle, Lucas T., Díez-Obrero, Virginia, Plummer, Sarah J., Moreno, Victor, Casey, Graham

Volltext

A deep-learning framework to predict cancer treatment response from histopathology images through imputed transcriptomics von Hoang, Danh-Tai, Dinstag, Gal, Shulman, Eldad D, Hermida, Leandro C, Ben-Zvi, Doreen S, Elis, Efrat, Caley, Katherine, Sammut, Stephen-John, Sinha, Sanju, Sinha, Neelam, Dampier, Christopher H, Stossel, Chani, Patil, Tejas, Rajan, Arun, Lassoued, Wiem, Strauss, Julius, Bailey, Shania, Allen, Clint, Redman, Jason, Beker, Tuvik, Jiang, Peng, Golan, Talia, Wilkinson, Scott, Sowalsky, Adam G, Pine, Sharon R, Caldas, Carlos, Gulley, James L, Aldape, Kenneth, Aharonov, Ranit, Stone, Eric A, Ruppin, Eytan

Volltext

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk von Thomas, Minta, Sakoda, Lori C., Hoffmeister, Michael, Rosenthal, Elisabeth A., Lee, Jeffrey K., van Duijnhoven, Franzel J.B., Platz, Elizabeth A., Wu, Anna H., Dampier, Christopher H., de la Chapelle, Albert, Wolk, Alicja, Joshi, Amit D., Burnett-Hartman, Andrea, Gsur, Andrea, Lindblom, Annika, Castells, Antoni, Win, Aung Ko, Namjou, Bahram, Van Guelpen, Bethany, Tangen, Catherine M., He, Qianchuan, Li, Christopher I., Schafmayer, Clemens, Joshu, Corinne E., Ulrich, Cornelia M., Bishop, D. Timothy, Buchanan, Daniel D., Schaid, Daniel, Drew, David A., Muller, David C., Duggan, David, Crosslin, David R., Albanes, Demetrius, Giovannucci, Edward L., Larson, Eric, Qu, Flora, Mentch, Frank, Giles, Graham G., Hakonarson, Hakon, Hampel, Heather, Stanaway, Ian B., Figueiredo, Jane C., Huyghe, Jeroen R., Minnier, Jessica, Chang-Claude, Jenny, Hampe, Jochen, Harley, John B., Visvanathan, Kala, Curtis, Keith R., Offit, Kenneth, Li, Li, Le Marchand, Loic, Vodickova, Ludmila, Gunter, Marc J., Jenkins, Mark A., Slattery, Martha L., Lemire, Mathieu, Woods, Michael O., Song, Mingyang, Murphy, Neil, Lindor, Noralane M., Dikilitas, Ozan, Pharoah, Paul D.P., Campbell, Peter T., Newcomb, Polly A., Milne, Roger L., MacInnis, Robert J., Castellví-Bel, Sergi, Ogino, Shuji, Berndt, Sonja I., Bézieau, Stéphane, Thibodeau, Stephen N., Gallinger, Steven J., Zaidi, Syed H., Harrison, Tabitha A., Keku, Temitope O., Hudson, Thomas J., Vymetalkova, Veronika, Moreno, Victor, Martín, Vicente, Arndt, Volker, Wei, Wei-Qi, Chung, Wendy, Su, Yu-Ru, Hayes, Richard B., White, Emily, Vodicka, Pavel, Casey, Graham, Gruber, Stephen B., Schoen, Robert E., Chan, Andrew T., Potter, John D., Brenner, Hermann, Jarvik, Gail P., Corley, Douglas A., Peters, Ulrike, Hsu, Li

Volltext

Abstract 2578: Calcium modulates apoptosis and differentiation in human normal colon 3D organoids irrespective of donor sex and biopsy site von Dampier, Christopher H., Devall, Matthew, Bryant, Jennifer, Eaton, Stephen D., Huyghe, Jeroen R., Kim, Andre E., Diez-Obrero, Virginia, van Duijnhoven, Franzel J., Thomas, Duncan C., Powell, Steven M., Gauderman, W James, Peters, Ulrike, Casey, Graham

Volltext

Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses von Dimou, Niki, Kim, Andre E., Flanagan, Orlagh, Murphy, Neil, Diez-Obrero, Virginia, Shcherbina, Anna, Aglago, Elom K., Bouras, Emmanouil, Campbell, Peter T., Casey, Graham, Gallinger, Steven, Gruber, Stephen B., Jenkins, Mark A., Lin, Yi, Moreno, Victor, Ruiz-Narvaez, Edward, Stern, Mariana C., Tian, Yu, Tsilidis, Kostas K., Arndt, Volker, Barry, Elizabeth L., Baurley, James W., Berndt, Sonja I., Bézieau, Stéphane, Bien, Stephanie A., Bishop, D. Timothy, Brenner, Hermann, Budiarto, Arif, Carreras-Torres, Robert, Cenggoro, Tjeng Wawan, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Chen, Xuechen, Conti, David V., Dampier, Christopher H., Devall, Matthew, Drew, David A., Figueiredo, Jane C., Giles, Graham G., Gsur, Andrea, Harrison, Tabitha A., Hidaka, Akihisa, Hoffmeister, Michael, Huyghe, Jeroen R., Jordahl, Kristina, Kawaguchi, Eric, Keku, Temitope O., Larsson, Susanna C., Le Marchand, Loic, Lewinger, Juan Pablo, Li, Li, Mahesworo, Bharuno, Morrison, John, Newcomb, Polly A., Newton, Christina C., Obon-Santacana, Mireia, Ose, Jennifer, Pai, Rish K., Palmer, Julie R., Papadimitriou, Nikos, Pardamean, Bens, Peoples, Anita R., Pharoah, Paul D. P., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Scacheri, Peter C., Schoen, Robert E., Su, Yu-Ru, Tangen, Catherine M., Thibodeau, Stephen N., Thomas, Duncan C., Ulrich, Cornelia M., Um, Caroline Y., van Duijnhoven, Franzel J. B., Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, White, Emily, Wolk, Alicja, Woods, Michael O., Qu, Conghui, Kundaje, Anshul, Hsu, Li, Gauderman, W. James, Gunter, Marc J., Peters, Ulrike

Volltext

Novel insights into the molecular mechanisms underlying risk of colorectal cancer from smoking and red/processed meat carcinogens by modeling exposure in normal colon organoids von Devall, Matthew, Dampier, Christopher H, Eaton, Stephen, Ali, Mourad W, Diez Obrero, Virginia, Moratalla Navarro, Ferran, Bryant, Jennifer, Jennelle, Lucas T, Moreno Aguado, Víctor, Powell, Steven M, Peters, Ulrike, Casey, Graham

Volltext

Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region von Jordahl, Kristina M, Shcherbina, Anna, Kim, Andre E, Su, Yu-Ru, Lin, Yi, Wang, Jun, Qu, Conghui, Albanes, Demetrius, Arndt, Volker, Baurley, James W, Berndt, Sonja I, Bien, Stephanie A, Bishop, D Timothy, Bouras, Emmanouil, Brenner, Hermann, Buchanan, Daniel D, Budiarto, Arif, Campbell, Peter T, Carreras-Torres, Robert, Casey, Graham, Cenggoro, Tjeng Wawan, Chan, Andrew T, Conti, David V, Dampier, Christopher H, Devall, Matthew A, Díez-Obrero, Virginia, Dimou, Niki, Drew, David A, Figueiredo, Jane C, Gallinger, Steven, Giles, Graham G, Gruber, Stephen B, Gsur, Andrea, Gunter, Marc J, Hampel, Heather, Harlid, Sophia, Harrison, Tabitha A, Hidaka, Akihisa, Hoffmeister, Michael, Huyghe, Jeroen R, Jenkins, Mark A, Joshi, Amit D, Keku, Temitope O, Larsson, Susanna C, Le Marchand, Loic, Lewinger, Juan Pablo, Li, Li, Mahesworo, Bharuno, Moreno, Victor, Morrison, John L, Murphy, Neil, Nan, Hongmei, Nassir, Rami, Newcomb, Polly A, Obón-Santacana, Mireia, Ogino, Shuji, Ose, Jennifer, Pai, Rish K, Palmer, Julie R, Papadimitriou, Nikos, Pardamean, Bens, Peoples, Anita R, Pharoah, Paul D P, Platz, Elizabeth A, Potter, John D, Prentice, Ross L, Rennert, Gad, Ruiz-Narvaez, Edward, Sakoda, Lori C, Scacheri, Peter C, Schmit, Stephanie L, Schoen, Robert E, Slattery, Martha L, Stern, Mariana C, Tangen, Catherine M, Thibodeau, Stephen N, Thomas, Duncan C, Tian, Yu, Tsilidis, Konstantinos K, Ulrich, Cornelia M, van Duijnhoven, Franzel J B, Van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Zemlianskaia, Natalia, Chang-Claude, Jenny, Gauderman, W James, Hsu, Li, Kundaje, Anshul, Peters, Ulrike

Volltext

Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response von Carreras-Torres, Robert, Kim, Andre E, Lin, Yi, Díez-Obrero, Virginia, Bien, Stephanie A, Qu, Conghui, Wang, Jun, Dimou, Niki, Aglago, Elom K, Albanes, Demetrius, Arndt, Volker, Baurley, James W, Berndt, Sonja I, Bézieau, Stéphane, Bishop, D Timothy, Bouras, Emmanouil, Brenner, Hermann, Budiarto, Arif, Campbell, Peter T, Casey, Graham, Chan, Andrew T, Chang-Claude, Jenny, Chen, Xuechen, Conti, David V, Dampier, Christopher H, Devall, Matthew A M, Drew, David A, Figueiredo, Jane C, Gallinger, Steven, Giles, Graham G, Gruber, Stephen B, Gsur, Andrea, Gunter, Marc J, Harrison, Tabitha A, Hidaka, Akihisa, Hoffmeister, Michael, Huyghe, Jeroen R, Jenkins, Mark A, Jordahl, Kristina M, Kawaguchi, Eric, Keku, Temitope O, Kundaje, Anshul, Le Marchand, Loic, Lewinger, Juan Pablo, Li, Li, Mahesworo, Bharuno, Morrison, John L, Murphy, Neil, Nan, Hongmei, Nassir, Rami, Newcomb, Polly A, Obón-Santacana, Mireia, Ogino, Shuji, Ose, Jennifer, Pai, Rish K, Palmer, Julie R, Papadimitriou, Nikos, Pardamean, Bens, Peoples, Anita R, Pharoah, Paul D P, Platz, Elizabeth A, Rennert, Gad, Ruiz-Narvaez, Edward, Sakoda, Lori C, Scacheri, Peter C, Schmit, Stephanie L, Schoen, Robert E, Shcherbina, Anna, Slattery, Martha L, Stern, Mariana C, Su, Yu-Ru, Tangen, Catherine M, Thomas, Duncan C, Tian, Yu, Tsilidis, Konstantinos K, Ulrich, Cornelia M, van Duijnhoven, Fränzel J B, Van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Cenggoro, Tjeng Wawan, Weinstein, Stephanie J, White, Emily, Wolk, Alicja, Woods, Michael O, Hsu, Li, Peters, Ulrike, Moreno, Victor, Gauderman, W James

Volltext

Colon Crypts of Subjects With Familial Adenomatous Polyposis Show an Increased Number of LGR5+Ectopic Stem Cells von Jennelle, Lucas T., Dampier, Christopher H., Tring, Stephanie, Powell, Steven, Casey, Graham

Volltext

Response to Li and Hopper von Thomas, Minta, Sakoda, Lori C., Hoffmeister, Michael, Rosenthal, Elisabeth A., Lee, Jeffrey K., van Duijnhoven, Franzel J. B., Platz, Elizabeth A., Wu, Anna H., Dampier, Christopher H., de la Chapelle, Albert, Wolk, Alicja, Joshi, Amit D., Burnett-Hartman, Andrea, Gsur, Andrea, Lindblom, Annika, Castells, Antoni, Kowin, Aung, Namjou, Bahram, Van Guelpen, Bethany, Tangen, Catherine M., He, Qianchuan, Li, Christopher I., Schafmayer, Clemens, Joshu, Corinne E., Ulrich, Cornelia M., Bishop, D. Timothy, Buchanan, Daniel D., Schaid, Daniel, Drew, David A., Muller, David C., Duggan, David, Crosslin, David R., Albanes, Demetrius, Giovannucci, Edward L., Larson, Eric, Qu, Flora, Mentch, Frank, Giles, Graham G., Hakonarson, Hakon, Hampel, Heather, Stanaway, Ian B., Figueiredo, Jane C., Huyghe, Jeroen R., Minnier, Jessica, Chang-Claude, Jenny, Hampe, Jochen, Harley, John B., Visvanathan, Kala, Curtis, Keith R., Offit, Kenneth, Li, Li, Le Marchand, Loic, Vodickova, Ludmila, Gunter, Marc J., Jenkins, Mark A., Slattery, Martha L., Lemire, Mathieu, Woods, Michael O., Song, Mingyang, Murphy, Neil, Lindor, Noralane M., Dikilitas, Ozan, Pharoah, Paul D. P., Campbell, Peter T., Newcomb, Polly A., Milne, Roger L., MacInnis, Robert J., Castellvi-Bel, Sergi, Ogino, Shuji, Berndt, Sonja I., Bezieau, Stephane, Thibodeau, Stephen N., Gallinger, Steven J., Zaidi, Syed H., Harrison, Tabitha A., Keku, Temitope O., Hudson, Thomas J., Vymetalkova, Veronika, Moreno, Victor, Martin, Vicente, Arndt, Volker, Wei, Wei-Qi, Chung, Wendy, Su, Yu-Ru, Hayes, Richard B., White, Emily, Vodicka, Pavel, Casey, Graham, Gruber, Stephen B., Schoen, Robert E., Chan, Andrew T., Potter, John D., Brenner, Hermann, Jarvik, Gail P., Corley, Douglas A., Peters, Ulrike, Hsu, Li

Volltext

Transcriptome-wide in vitro effects of aspirin on patient-derived normal colon organoids: Impact of aspirin on colon epithelial transcription von Devall, Matthew A. M., Drew, David A., Dampier, Christopher H., Plummer, Sarah J., Eaton, Stephen, Bryant, Jennifer, Díez-Obrero, Virginia, Mo, Jiancheng, Kedrin, Dmitriy, Zerjav, Dylan C., Takacsi-Nagy, Oliver, Jennelle, Lucas T., Ali, Mourad W., Yilmaz, Ömer H., Moreno, Victor, Powell, Steven M., Chan, Andrew T., Peters, Ulrike, Casey, Graham

Volltext