Ethanol exposure drives colon location specific cell composition changes in a normal colon crypt 3D organoid model von Devall, Matthew, Plummer, Sarah J., Bryant, Jennifer, Jennelle, Lucas T., Eaton, Stephen, Dampier, Christopher H., Huyghe, Jeroen R., Peters, Ulrike, Powell, Steven M., Casey, Graham

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A functional variant on 20q13.33 related to glioma risk alters enhancer activity and modulates expression of multiple genes von Ali, Mourad Wagdy, Patro, C. Pawan K., Zhu, Jacqueline Jufen, Dampier, Christopher H., Plummer, Sarah J., Kuscu, Cem, Adli, Mazhar, Lau, Ching, Lai, Rose K., Casey, Graham

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A Functional Variant on 9p21.3 Related to Glioma Risk Affects Enhancer Activity and Modulates Expression of CDKN2B‐AS1 von Ali, Mourad Wagdy, Patro, C. Pawan K., Devall, Matthew, Dampier, Christopher H., Plummer, Sarah J., Kuscu, Cem, Adli, Mazhar, Lai, Rose K., Casey, Graham

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Transcriptome-Wide Association Study for Inflammatory Bowel Disease Reveals Novel Candidate Susceptibility Genes in Specific Colon Subsites and Tissue Categories von Díez-Obrero, Virginia, Moratalla-Navarro, Ferran, Ibáñez-Sanz, Gemma, Guardiola, Jordi, Rodríguez-Moranta, Francisco, Obón-Santacana, Mireia, Díez-Villanueva, Anna, Dampier, Christopher Heaton, Devall, Matthew, Carreras-Torres, Robert, Casey, Graham, Moreno, Victor

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DNA methylation analysis of normal colon organoids from familial adenomatous polyposis patients reveals novel insight into colon cancer development von Devall, Matthew A, Eaton, Stephen, Ali, Mourad Wagdy, Dampier, Christopher H, Weisenberger, Daniel, Powell, Steven M, Li, Li, Casey, Graham

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Transcriptomic Response to Calcium in Normal Colon Organoids is Impacted by Colon Location and Sex von Devall, Matthew A M, Dampier, Christopher H, Eaton, Stephen, Ali, Mourad Wagdy, Plummer, Sarah J, Bryant, Jennifer, Gauderman, W James, Peters, Ulrike, Powell, Steven M, Casey, Graham

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Colon Crypts of Subjects With Familial Adenomatous Polyposis Show an Increased Number of LGR5+ Ectopic Stem Cells von Jennelle, Lucas T., Dampier, Christopher H., Tring, Stephanie, Powell, Steven, Casey, Graham

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Transcriptome-wide In Vitro Effects of Aspirin on Patient-derived Normal Colon Organoids von Devall, Matthew A. M., Drew, David A., Dampier, Christopher H., Plummer, Sarah J., Eaton, Stephen, Bryant, Jennifer, Diez-Obrero, Virginia, Mo, Jiancheng, Kedrin, Dmitriy, Zerjav, Dylan C., Takacsi-Nagy, Oliver, Jennelle, Lucas T., Ali, Mourad W., Yilmaz, Omer H., Moreno, Victor, Powell, Steven M., Chan, Andrew T., Peters, Ulrike, Casey, Graham

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Novel insights into the molecular mechanisms underlying risk of colorectal cancer from smoking and red/processed meat carcinogens by modeling exposure in normal colon organoids von Devall, Matthew, Dampier, Christopher H., Eaton, Stephen, Ali, Mourad W., Díez-Obrero, Virginia, Moratalla-Navarro, Ferran, Bryant, Jennifer, Jennelle, Lucas T., Moreno, Victor, Powell, Steven M., Peters, Ulrike, Casey, Graham

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Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion von Andreiuolo, Felipe, Ferrone, Christina K, Rajan, Sharika, Perry, Arie, Guney, Ekin, Cham, Elaine, Giannini, Caterina, Toland, Angus, Willard, Nicholas, de Souza, Andrea Silveira, Dazelle, Karen, Chung, Hye-Jung, Singh, Omkar, Conway, Kyle, Coley, Nicholas, Dampier, Christopher, Abdullaev, Zied, Pratt, Drew, Cimino, Patrick J, Quezado, Martha, Aldape, Kenneth

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Genetic Effects on Transcriptome Profiles in Colon Epithelium Provide Functional Insights for Genetic Risk Loci von Díez-Obrero, Virginia, Dampier, Christopher H., Moratalla-Navarro, Ferran, Devall, Matthew, Plummer, Sarah J., Díez-Villanueva, Anna, Peters, Ulrike, Bien, Stephanie, Huyghe, Jeroen R., Kundaje, Anshul, Ibáñez-Sanz, Gemma, Guinó, Elisabeth, Obón-Santacana, Mireia, Carreras-Torres, Robert, Casey, Graham, Moreno, Víctor

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Oncogenic Features in Histologically Normal Mucosa: Novel Insights Into Field Effect From a Mega-Analysis of Colorectal Transcriptomes von Dampier, Christopher H., Devall, Matthew, Jennelle, Lucas T., Díez-Obrero, Virginia, Plummer, Sarah J., Moreno, Victor, Casey, Graham

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A deep-learning framework to predict cancer treatment response from histopathology images through imputed transcriptomics von Hoang, Danh-Tai, Dinstag, Gal, Shulman, Eldad D, Hermida, Leandro C, Ben-Zvi, Doreen S, Elis, Efrat, Caley, Katherine, Sammut, Stephen-John, Sinha, Sanju, Sinha, Neelam, Dampier, Christopher H, Stossel, Chani, Patil, Tejas, Rajan, Arun, Lassoued, Wiem, Strauss, Julius, Bailey, Shania, Allen, Clint, Redman, Jason, Beker, Tuvik, Jiang, Peng, Golan, Talia, Wilkinson, Scott, Sowalsky, Adam G, Pine, Sharon R, Caldas, Carlos, Gulley, James L, Aldape, Kenneth, Aharonov, Ranit, Stone, Eric A, Ruppin, Eytan

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Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk von Thomas, Minta, Sakoda, Lori C., Hoffmeister, Michael, Rosenthal, Elisabeth A., Lee, Jeffrey K., van Duijnhoven, Franzel J.B., Platz, Elizabeth A., Wu, Anna H., Dampier, Christopher H., de la Chapelle, Albert, Wolk, Alicja, Joshi, Amit D., Burnett-Hartman, Andrea, Gsur, Andrea, Lindblom, Annika, Castells, Antoni, Win, Aung Ko, Namjou, Bahram, Van Guelpen, Bethany, Tangen, Catherine M., He, Qianchuan, Li, Christopher I., Schafmayer, Clemens, Joshu, Corinne E., Ulrich, Cornelia M., Bishop, D. Timothy, Buchanan, Daniel D., Schaid, Daniel, Drew, David A., Muller, David C., Duggan, David, Crosslin, David R., Albanes, Demetrius, Giovannucci, Edward L., Larson, Eric, Qu, Flora, Mentch, Frank, Giles, Graham G., Hakonarson, Hakon, Hampel, Heather, Stanaway, Ian B., Figueiredo, Jane C., Huyghe, Jeroen R., Minnier, Jessica, Chang-Claude, Jenny, Hampe, Jochen, Harley, John B., Visvanathan, Kala, Curtis, Keith R., Offit, Kenneth, Li, Li, Le Marchand, Loic, Vodickova, Ludmila, Gunter, Marc J., Jenkins, Mark A., Slattery, Martha L., Lemire, Mathieu, Woods, Michael O., Song, Mingyang, Murphy, Neil, Lindor, Noralane M., Dikilitas, Ozan, Pharoah, Paul D.P., Campbell, Peter T., Newcomb, Polly A., Milne, Roger L., MacInnis, Robert J., Castellví-Bel, Sergi, Ogino, Shuji, Berndt, Sonja I., Bézieau, Stéphane, Thibodeau, Stephen N., Gallinger, Steven J., Zaidi, Syed H., Harrison, Tabitha A., Keku, Temitope O., Hudson, Thomas J., Vymetalkova, Veronika, Moreno, Victor, Martín, Vicente, Arndt, Volker, Wei, Wei-Qi, Chung, Wendy, Su, Yu-Ru, Hayes, Richard B., White, Emily, Vodicka, Pavel, Casey, Graham, Gruber, Stephen B., Schoen, Robert E., Chan, Andrew T., Potter, John D., Brenner, Hermann, Jarvik, Gail P., Corley, Douglas A., Peters, Ulrike, Hsu, Li

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PATH-57. CLINICAL AND MOLECULAR FEATURES OF METHYLATION CLASS DIFFUSE LEPTOMENINGEAL GLIONEURONAL TUMOR von Dampier, Christopher, Singh, Omkar, Nasrallah, MacLean, Rodriguez, Fausto, Eschbacher, Jennifer, Morris, Meaghan, Abdullaev, Zied, Quezado, Martha, Pratt, Drew, Cimino, P J, Aldape, Kenneth

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MYB/MYBL1-altered gliomas frequently harbor truncations and non-productive fusions in the MYB and MYBL1 genes von Chung, Hye-Jung, Rajan, Sharika, Wu, Zhichao, Ferrone, Christina K., Raffeld, Mark, Lee, Ina, Gagan, Jeffrey, Dampier, Christopher, Abdullaev, Zied, Tyagi, Manoj, Cimino, Patrick. J., Quezado, Martha, Aldape, Kenneth

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Novel insights into genetic susceptibility for colorectal cancer from transcriptome-wide association and functional investigation von Chen, Zhishan, Song, Wenqiang, Shu, Xiao-Ou, Wen, Wanqing, Devall, Matthew, Dampier, Christopher, Moratalla-Navarro, Ferran, Cai, Qiuyin, Long, Jirong, Van Kaer, Luc, Wu, Lan, Huyghe, Jeroen R, Thomas, Minta, Hsu, Li, Woods, Michael O, Albanes, Demetrius, Buchanan, Daniel D, Gsur, Andrea, Hoffmeister, Michael, Vodicka, Pavel, Wolk, Alicja, Marchand, Loic Le, Wu, Anna H, Phipps, Amanda I, Moreno, Victor, Ulrike, Peters, Zheng, Wei, Casey, Graham, Guo, Xingyi

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Abstract 2578: Calcium modulates apoptosis and differentiation in human normal colon 3D organoids irrespective of donor sex and biopsy site von Dampier, Christopher H., Devall, Matthew, Bryant, Jennifer, Eaton, Stephen D., Huyghe, Jeroen R., Kim, Andre E., Diez-Obrero, Virginia, van Duijnhoven, Franzel J., Thomas, Duncan C., Powell, Steven M., Gauderman, W James, Peters, Ulrike, Casey, Graham

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Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses von Dimou, Niki, Kim, Andre E., Flanagan, Orlagh, Murphy, Neil, Diez-Obrero, Virginia, Shcherbina, Anna, Aglago, Elom K., Bouras, Emmanouil, Campbell, Peter T., Casey, Graham, Gallinger, Steven, Gruber, Stephen B., Jenkins, Mark A., Lin, Yi, Moreno, Victor, Ruiz-Narvaez, Edward, Stern, Mariana C., Tian, Yu, Tsilidis, Kostas K., Arndt, Volker, Barry, Elizabeth L., Baurley, James W., Berndt, Sonja I., Bézieau, Stéphane, Bien, Stephanie A., Bishop, D. Timothy, Brenner, Hermann, Budiarto, Arif, Carreras-Torres, Robert, Cenggoro, Tjeng Wawan, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Chen, Xuechen, Conti, David V., Dampier, Christopher H., Devall, Matthew, Drew, David A., Figueiredo, Jane C., Giles, Graham G., Gsur, Andrea, Harrison, Tabitha A., Hidaka, Akihisa, Hoffmeister, Michael, Huyghe, Jeroen R., Jordahl, Kristina, Kawaguchi, Eric, Keku, Temitope O., Larsson, Susanna C., Le Marchand, Loic, Lewinger, Juan Pablo, Li, Li, Mahesworo, Bharuno, Morrison, John, Newcomb, Polly A., Newton, Christina C., Obon-Santacana, Mireia, Ose, Jennifer, Pai, Rish K., Palmer, Julie R., Papadimitriou, Nikos, Pardamean, Bens, Peoples, Anita R., Pharoah, Paul D. P., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Scacheri, Peter C., Schoen, Robert E., Su, Yu-Ru, Tangen, Catherine M., Thibodeau, Stephen N., Thomas, Duncan C., Ulrich, Cornelia M., Um, Caroline Y., van Duijnhoven, Franzel J. B., Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, White, Emily, Wolk, Alicja, Woods, Michael O., Qu, Conghui, Kundaje, Anshul, Hsu, Li, Gauderman, W. James, Gunter, Marc J., Peters, Ulrike

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Novel insights into the molecular mechanisms underlying risk of colorectal cancer from smoking and red/processed meat carcinogens by modeling exposure in normal colon organoids von Devall, Matthew, Dampier, Christopher H, Eaton, Stephen, Ali, Mourad W, Diez Obrero, Virginia, Moratalla Navarro, Ferran, Bryant, Jennifer, Jennelle, Lucas T, Moreno Aguado, Víctor, Powell, Steven M, Peters, Ulrike, Casey, Graham

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