Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis von Kong, G, Chang, Y-I, Damnernsawad, A, You, X, Du, J, Ranheim, E A, Lee, W, Ryu, M-J, Zhou, Y, Xing, Y, Chang, Q, Burd, C E, Zhang, J

Volltext

Genome-wide identification of genes involved in tolerance to various environmental stresses in Saccharomyces cerevisiae von Auesukaree, C, Damnernsawad, A, Kruatrachue, M, Pokethitiyook, P, Boonchird, C, Kaneko, Y, Harashima, S

Volltext

Genome-wide identification of genes involved in tolerance to various environmental stresses inSaccharomyces cerevisiae von Auesukaree, C., Damnernsawad, A., Kruatrachue, M., Pokethitiyook, P., Boonchird, C., Kaneko, Y., Harashima, S.

Volltext

A genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways that mediate resistance to sorafenib in acute myeloid leukemia von Damnernsawad, Alisa, Bottomly, Daniel, Kurtz, Stephen E., Eide, Christopher A., McWeeney, Shannon K., Tyner, Jeffrey W., Nechiporuk, Tamilla

Volltext

Proteolysis targeting chimeric molecules as therapy for multiple myeloma: efficacy, biomarker and drug combinations von Lim, Su Lin, Damnernsawad, Alisa, Shyamsunder, Pavithra, Chng, Wee Joo, Han, Bing Chen, Xu, Liang, Pan, Jian, Pravin, Dakle Pushkar, Alkan, Serhan, Tyner, Jeffrey W, Koeffler, H Phillip

Volltext

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells von Edwards, David K., Watanabe-Smith, Kevin, Rofelty, Angela, Damnernsawad, Alisa, Laderas, Ted, Lamble, Adam, Lind, Evan F., Kaempf, Andy, Mori, Motomi, Rosenberg, Mara, d'Almeida, Amanda, Long, Nicola, Agarwal, Anupriya, Sweeney, David Tyler, Loriaux, Marc, McWeeney, Shannon K., Tyner, Jeffrey W.

Volltext

Kras is Required for Adult Hematopoiesis von Damnernsawad, Alisa, Kong, Guangyao, Wen, Zhi, Liu, Yangang, Rajagopalan, Adhithi, You, Xiaona, Wang, Jinyong, Zhou, Yun, Ranheim, Erik A., Luo, Hongbo R., Chang, Qiang, Zhang, Jing

Volltext

Abstract 1429: Characterization of trametinib combined with venetoclax in acute myeloid leukemia (AML) treatment von Damnernsawad, Alisa, Eide, Christopher A., Beer, Sofia, Zhang, Haijiao, Bottomly, Daniel, Kurtz, Stephen E., Tyner, Jeffrey W.

Volltext

Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm von Kong, Guangyao, Wunderlich, Mark, Yang, David, Ranheim, Erik A, Young, Ken H, Wang, Jinyong, Chang, Yuan-I, Du, Juan, Liu, Yangang, Tey, Sin Ruow, Zhang, Xinmin, Juckett, Mark, Mattison, Ryan, Damnernsawad, Alisa, Zhang, Jingfang, Mulloy, James C, Zhang, Jing

Volltext

Abstract 5942: An integrated approach reveals novel extrinsic pathways and cytokine signatures associated with drug response in acute myeloid leukemia von Modak, Rucha V., Damnernsawad, Alisa, Laderas, Ted, Wu, Guanming, Tyner, Jeffery W., Rodland, Karin D., McWeeney, Shannon K., Agarwal, Anupriya

Volltext

cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors von Wen, Zhi, Yun, Grant, Hebert, Alexander, Kong, Guangyao, Ranheim, Erik A., Finn, Remington, Rajagoplan, Adhithi, Li, Shuyi, Zhou, Yun, Yu, Mei, Damnernsawad, Alisa, Roose, Jeroen P., Coon, Joshua J., Wen, Renren, Wang, Demin, Zhang, Jing

Volltext

Genome-Wide CRISPR Screening Identifies MAPK and Mtorc Pathways As Regulators of Sorafenib Resistance in Acute Myeloid Leukemia von Damnernsawad, Alisa, Nechiporuk, Tamilla, Bottomly, Daniel, Kurtz, Stephen E, Eide, Christopher A., McWeeney, Shannon K., Tyner, Jeffrey W.

Volltext

The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption von Anderson, Sheila A., Nizzi, Christopher P., Chang, Yuan-I., Deck, Kathryn M., Schmidt, Paul J., Galy, Bruno, Damnernsawad, Alisa, Broman, Aimee T., Kendziorski, Christina, Hentze, Matthias W., Fleming, Mark D., Zhang, Jing, Eisenstein, Richard S.

Volltext

Abstract 4763: Genome-wide CRISPR screening identifies TSC1 as a regulator of sorafenib resistance in acute myeloid leukemia von Damnernsawad, Alisa, Nechiporuk, Tamilla, Kurtz, Steve E., Horton, Wesley R., Nikolova, Olga, McWeeney, Shannon K., Tyner, Jeffrey W.

Volltext

Embryonic Expression of NrasG 12 D Leads to Embryonic Lethality and Cardiac Defects von You, Xiaona, Ryu, Myung-Jeom, Cho, Eunjin, Sang, Yanzhi, Damnernsawad, Alisa, Zhou, Yun, Liu, Yangang, Zhang, Jing, Lee, Youngsook

Volltext

Genome-Wide CRISPR Screening in Acute Myeloid Leukemia Cells Identifies Genes in the PI3K/AKT/mTOR and MEK/ERK Pathways That Define Sensitivity to Trametinib von Nechiporuk, Tamilla, Damnernsawad, Alisa, Bottomly, Daniel, Morrow, Quinlan, Choi, Suyoun, Beer, Sofia, Kurtz, Stephen E, McWeeney, Shannon K., Tyner, Jeffrey W.

Volltext

A Functional Profiling of Microenvironmental Factors and Small Molecules Reveals Monocyte Chemoattractant Protein-1 Mediates Drug Resistance in Acute Myeloid Leukemia von Modak, Rucha V, Gosline, Sara J, Damnernsawad, Alisa, Nechiporuk, Tamilla, Laderas, Ted, Wu, Guanming, Piehowski, Paul, Kurtz, Stephen E, Eide, Christopher A., Tyner, Jeffrey W., Rodland, Karin, McWeeney, Shannon K., Agarwal, Anupriya

Volltext

Kras-Deficient T Cells Attenuate Graft-versus-Host Disease but Retain Graft-versus-Leukemia Activity von Luo, Lan, Chen, Yuhong, Chen, Xiao, Zheng, Yongwei, Zhou, Vivian, Yu, Mei, Burns, Robert, Zhu, Wen, Fu, Guoping, Felix, Juan C., Hartley, Christopher, Damnernsawad, Alisa, Zhang, Jing, Wen, Renren, Drobyski, Williams R., Gao, Chunji, Wang, Demin

Volltext

NrasQ61R/+ and Kras−/− cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors von Wen, Zhi, Yun, Grant, Hebert, Alexander, Kong, Guangyao, Ranheim, Erik A., Finn, Remington, Rajagoplan, Adhithi, Li, Shuyi, Zhou, Yun, Yu, Mei, Damnernsawad, Alisa, Roose, Jeroen P., Coon, Joshua J., Wen, Renren, Wang, Demin, Zhang, Jing

Volltext

Nras Q61R/+ and Kras −/− cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors von Wen, Zhi, Yun, Grant, Hebert, Alexander, Kong, Guangyao, Ranheim, Erik A., Finn, Remington, Rajagoplan, Adhithi, Li, Shuyi, Zhou, Yun, Yu, Mei, Damnernsawad, Alisa, Roose, Jeroen P., Coon, Joshua J., Wen, Renren, Wang, Demin, Zhang, Jing

Volltext