Cytochrome P450 and Non-Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics von Foti, Robert S, Dalvie, Deepak K

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Predicting Toxicities of Reactive Metabolite-Positive Drug Candidates von Kalgutkar, Amit S, Dalvie, Deepak

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Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator von Surapaneni, Sekhar, Yerramilli, Usha, Bai, April, Dalvie, Deepak, Brooks, Jennifer, Wang, Xiaomin, Selkirk, Julie, Yan, Yingzhuo Grace, Zhang, Peijin, Hargreaves, Richard, Kumar, Gondi, Palmisano, Maria, Tran, Jonathan Q.

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Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance von Schwartz, Phillip A., Kuzmic, Petr, Solowiej, James, Bergqvist, Simon, Bolanos, Ben, Almaden, Chau, Nagata, Asako, Ryan, Kevin, Feng, Junli, Dalvie, Deepak, Kath, John C., Xu, Meirong, Wani, Revati, Murray, Brion William

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Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as... von Crosignani, Stefano, Bingham, Patrick, Bottemanne, Pauline, Cannelle, Hélène, Cauwenberghs, Sandra, Cordonnier, Marie, Dalvie, Deepak, Deroose, Frederik, Feng, Jun Li, Gomes, Bruno, Greasley, Samantha, Kaiser, Stephen E, Kraus, Manfred, Négrerie, Michel, Maegley, Karen, Miller, Nichol, Murray, Brion W, Schneider, Manfred, Soloweij, James, Stewart, Albert E, Tumang, Joseph, Torti, Vince R, Van Den Eynde, Benoit, Wythes, Martin

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Utilizing mechanistic organic chemistry training to study drug metabolism in preclinical drug discovery/development von Dalvie, Deepak, Kalgutkar, Amit S.

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Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings von Dalvie, Deepak K, Kalgutkar, Amit S, Khojasteh-Bakht, S. Cyrus, Obach, R. Scott, O'Donnell, John P

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Aldehyde oxidase and its role as a drug metabolizing enzyme von Dalvie, Deepak, Di, Li

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Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockad... von Gomes, Bruno, Driessens, Gregory, Bartlett, Derek, Cai, Danying, Cauwenberghs, Sandra, Crosignani, Stefano, Dalvie, Deepak, Denies, Sofie, Dillon, Christopher P, Fantin, Valeria R, Guo, Jie, Letellier, Marie-Claire, Li, Wenlin, Maegley, Karen, Marillier, Reece, Miller, Nichol, Pirson, Romain, Rabolli, Virginie, Ray, Chad, Streiner, Nicole, Torti, Vince R, Tsaparikos, Konstantinos, Van den Eynde, Benoit J, Wythes, Martin, Yao, Li-Chin, Zheng, Xianxian, Tumang, Joseph, Kraus, Manfred

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The Generation, Detection, and Effects of Reactive Drug Metabolites von Stachulski, Andrew V., Baillie, Thomas A., Kevin Park, B., Scott Obach, R., Dalvie, Deepak K., Williams, Dominic P., Srivastava, Abhishek, Regan, Sophie L., Antoine, Daniel J., Goldring, Christopher E. P., Chia, Alvin J. L., Kitteringham, Neil R., Randle, Laura E., Callan, Hayley, Castrejon, J. Luis, Farrell, John, Naisbitt, Dean J., Lennard, Martin S.

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Pharmacokinetics, metabolism, and excretion of [14C]axitinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in humans von Smith, Bill J, Pithavala, Yazdi, Bu, Hai-Zhi, Kang, Ping, Hee, Brian, Deese, Alan J, Pool, William F, Klamerus, Karen J, Wu, Ellen Y, Dalvie, Deepak K

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Effect of structural variation on aldehyde oxidase-catalyzed oxidation of zoniporide von Dalvie, Deepak, Sun, Hao, Xiang, Cathie, Hu, Qiyue, Jiang, Ying, Kang, Ping

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Identification of Novel Substrates for Human Cytochrome P450 2J2 von LEE, Caroline A, NEUL, David, CLOUSER-ROCHE, Andrea, DALVIE, Deepak, WESTER, Michael R, YING JIANG, JONES, J. P, FREIWALD, Sascha, ZIENTEK, Michael, TOTAH, Rheem A

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Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery von Pryde, David C, Dalvie, Deepak, Hu, Qiyue, Jones, Peter, Obach, R. Scott, Tran, Thien-Duc

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Cross-Species Comparison of the Metabolism and Excretion of Zoniporide: Contribution of Aldehyde Oxidase to Interspecies Differences von DALVIE, Deepak, CHENGHONG ZHANG, WEICHAO CHEN, SMOLAREK, Teresa, OBACH, R. Scott, LOI, Cho-Ming

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Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes von Eng, Heather, Sharma, Raman, Wolford, Angela, Di, Li, Ruggeri, Roger B, Buckbinder, Leonard, Conn, Edward L, Dalvie, Deepak K, Kalgutkar, Amit S

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Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fat... von Harwood, H.James, Petras, Stephen F., Shelly, Lorraine D., Zaccaro, Lawrence M., Perry, David A., Makowski, Michael R., Hargrove, Diane M., Martin, Kelly A., Tracey, W.Ross, Chapman, Justin G., Magee, William P., Dalvie, Deepak K., Soliman, Victor F., Martin, William H., Mularski, Christian J., Eisenbeis, Shane A.

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Pharmacokinetics and Metabolism of 2-Aminothiazoles with Antiprion Activity in Mice von Silber, B. Michael, Rao, Satish, Fife, Kimberly L., Gallardo-Godoy, Alejandra, Renslo, Adam R., Dalvie, Deepak K., Giles, Kurt, Freyman, Yevgeniy, Elepano, Manuel, Gever, Joel R., Li, Zhe, Jacobson, Matthew P., Huang, Yong, Benet, Leslie Z., Prusiner, Stanley B.

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Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator von Sharma, Raman, Litchfield, John, Atkinson, Karen, Eng, Heather, Amin, Neeta B, Denney, William S, Pettersen, John C, Goosen, Theunis C, Di, Li, Lee, Esther, Pfefferkorn, Jeffrey A, Dalvie, Deepak K, Kalgutkar, Amit S

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Interactions of Nitrogen-Containing Xenobiotics with Monoamine Oxidase (MAO) Isozymes A and B:  SAR Studies on MAO Substrates and Inhibitors von Kalgutkar, Amit S, Dalvie, Deepak K, Castagnoli, Neal, Taylor, Timothy J

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