Strategy and success for the directed evolution of enzymes von Dalby, Paul A

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Two strategies to engineer flexible loops for improved enzyme thermostability von Yu, Haoran, Yan, Yihan, Zhang, Cheng, Dalby, Paul A.

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Two-substrate enzyme engineering using small libraries that combine the substrate preferences from two different variant lineages von Mukhopadhyay, Arka, Karu, Kersti, Dalby, Paul A.

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Engineering of enzymes using non-natural amino acids von Li, Yiwen, Dalby, Paul A

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Virus lasers for biological detection von Hales, John E., Matmon, Guy, Dalby, Paul A., Ward, John M., Aeppli, Gabriel

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Enzyme stabilisation due to incorporation of a fluorinated non-natural amino acid at the protein surface von Mukhopadhyay, Arka, Li, Yiwen, Cliff, Matthew J., Golovanov, Alexander P., Dalby, Paul A.

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Crystal structures and molecular dynamics simulations of a humanised antibody fragment at acidic to basic pH von Tang, Jiazhi, Zhang, Cheng, Castillo, Nuria Codina, Lalaurie, Christophe J., Gao, Xin, Dalby, Paul A., Kozielski, Frank

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Using atomistic solution scattering modelling to elucidate the role of the Fc glycans in human IgG4 von Spiteri, Valentina A, Doutch, James, Rambo, Robert P, Bhatt, Jayesh S, Gor, Jayesh, Dalby, Paul A, Perkins, Stephen J

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Mapping the Aggregation Kinetics of a Therapeutic Antibody Fragment von Chakroun, Nesrine, Hilton, David, Ahmad, Shahina S, Platt, Geoffrey W, Dalby, Paul A

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Computational Design To Reduce Conformational Flexibility and Aggregation Rates of an Antibody Fab Fragment von Zhang, Cheng, Samad, Maariyah, Yu, Haoran, Chakroun, Nesrine, Hilton, David, Dalby, Paul A

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Biophysical characterization of the inactivation of E. coli transketolase by aqueous co-solvents von Morris, Phattaraporn, García-Arrazola, Ribia, Rios-Solis, Leonardo, Dalby, Paul A.

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Functional and computational identification of a rescue mutation near the active site of an mRNA methyltransferase von Colin, Pierre-Yves, Dalby, Paul A.

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Exploiting correlated molecular-dynamics networks to counteract enzyme activity–stability trade-off von Yu, Haoran, Dalby, Paul A.

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Coupled molecular dynamics mediate long- and short-range epistasis between mutations that affect stability and aggregation kinetics von Yu, Haoran, Dalby, Paul A.

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Challenges in scaling up AAV-based gene therapy manufacturing von Jiang, Ziyu, Dalby, Paul A.

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Directed evolution for soluble and active periplasmic expression of bovine enterokinase in Escherichia coli von Lee, Weiluo, Pradhan, Subhas, Zhang, Cheng, Venanzi, Niccolo A. E., Li, Weina, Goldrick, Stephen, Dalby, Paul A.

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Hot spots-making directed evolution easier von Yu, Haoran, Ma, Shuang, Li, Yiwen, Dalby, Paul A.

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An Evaluation of the Potential of NMR Spectroscopy and Computational Modelling Methods to Inform Biopharmaceutical Formulations von Pandya, Akash, Howard, Mark J, Zloh, Mire, Dalby, Paul A

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Comparison of the pH- and thermally-induced fluctuations of a therapeutic antibody Fab fragment by molecular dynamics simulation von Zhang, Cheng, Codina, Nuria, Tang, Jiazhi, Yu, Haoran, Chakroun, Nesrine, Kozielski, Frank, Dalby, Paul A.

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Lyophilization to enable distribution of ChAdOx1 and ChAdOx2 adenovirus-vectored vaccines without refrigeration von Zhang, Cheng, Berg, Adam, Joe, Carina C. D., Dalby, Paul A., Douglas, Alexander D.

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