mexEF-oprN Multidrug Efflux Operon of Pseudomonas aeruginosa: Regulation by the MexT Activator in Response to Nitrosative Stress and Chloramphenicol von FETAR, Hossam, GILMOUR, Christie, KLINOSKI, Rachael, DAIGLE, Denis M, DEAN, Charles R, POOLE, Keith

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The Next-Generation beta-Lactamase Inhibitor Taniborbactam Restores the Morphological Effects of Cefepime in KPC-Producing Escherichia coli von Roach, Elyse J., Uehara, Tsuyoshi, Daigle, Denis M., Six, David A., Khursigara, Cezar M.

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Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections von Liu, Bin, Trout, Robert E. Lee, Chu, Guo-Hua, McGarry, Daniel, Jackson, Randy W, Hamrick, Jodie C, Daigle, Denis M, Cusick, Susan M, Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Docquier, Jean-Denis, Weiss, William J, Pevear, Daniel C, Xerri, Luigi, Burns, Christopher J

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VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-beta-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa von Hamrick, Jodie C., Docquier, Jean-Denis, Uehara, Tsuyoshi, Myers, Cullen L., Six, David A., Chatwin, Cassandra L., John, Kaitlyn J., Vernacchio, Salvador F., Cusick, Susan M., Trout, Robert E. L., Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Liu, Bin, Jackson, Randy W., Moeck, Greg, Xerri, Luigi, Burns, Christopher J., Pevear, Daniel C., Daigle, Denis M.

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Studies of the Interaction of Escherichia coli YjeQ with the Ribosome In Vitro von DAIGLE, Denis M, BROWN, Eric D

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In Vitro Activity of Cefepime-Taniborbactam and Comparators against Clinical Isolates of Gram-Negative Bacilli from 2018 to 2020: Results from the Global Evaluation of Antimicrobia... von Karlowsky, James A, Hackel, Meredith A, Wise, Mark G, Six, David A, Uehara, Tsuyoshi, Daigle, Denis M, Cusick, Susan M, Pevear, Daniel C, Moeck, Greg, Sahm, Daniel F

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Fmt Bypass in Pseudomonas aeruginosa Causes Induction of MexXY Efflux Pump Expression von CAUGHLAN, Ruth E, SRIRAM, Shubha, DAIGLE, Denis M, WOODS, Angela L, BUCO, Jennifer, PETERSON, Ron L, DZINK-FOX, Joann, WALKER, Susan, DEAN, Charles R

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Characterization of the Bacillus subtilis GTPase YloQ and its role in ribosome function von Campbell, Tracey L, Daigle, Denis M, Brown, Eric D

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Protein Modulator of Multidrug Efflux Gene Expression in Pseudomonas aeruginosa von DAIGLE, Denis M, LILY CAO, FRAUD, Sebastien, WILKE, Mark S, PACEY, Angela, KLINOSKI, Rachael, STRYNADKA, Natalie C, DEAN, Charles R, POOLE, Keith

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Microbiological Characterization of VNRX-5236, a Broad-Spectrum beta-Lactamase Inhibitor for Rescue of the Orally Bioavailable Cephalosporin Ceftibuten as a Carbapenem-Sparing Agen... von Chatwin, Cassandra L., Hamrick, Jodie C., Trout, Robert E. L., Myers, Cullen L., Cusick, Susan M., Weiss, William J., Pulse, Mark E., Xerri, Luigi, Burns, Christopher J., Moeck, Gregory, Daigle, Denis M., John, Kaitlyn, Uehara, Tsuyoshi, Pevear, Daniel C.

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Domain−Domain Interactions in the Aminoglycoside Antibiotic Resistance Enzyme AAC(6‘)-APH(2‘ ‘) von Boehr, David D, Daigle, Denis M, Wright, Gerard D

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Role of the AcrAB-TolC Efflux Pump in Determining Susceptibility of Haemophilus influenzae to the Novel Peptide Deformylase Inhibitor LBM415 von DEAN, Charles R, NARAYAN, Shubha, RYDER, Neil S, DAIGLE, Denis M, DZINK-FOX, Joann L, XIAOLING PUYANG, BRACKEN, Kathryn R, DEAN, Karl E, WEIDMANN, Beat, ZHENGYU YUAN, JAIN, Rakesh

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Reduced Susceptibility of Haemophilus influenzae to the Peptide Deformylase Inhibitor LBM415 Can Result from Target Protein Overexpression Due to Amplified Chromosomal def Gene Cop... von CHARLES, R, NARAYAN, Shubha, VOSHOL, Hans, VAN OOSTRUM, Jan, WALL, Daniel, KOEHN, James, DZINK-FOX, Joann, RYDER, Neil S, RICHARDS, Joel, DAIGLE, Denis M, ESTEROW, Stacy, LEEDS, Jennifer A, KAMP, Heather, PUYANG, Xiaoling, WIEDMANN, Brigitte, MUELLER, Dieter

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A 2.13 Å Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region von Summerfield, Rachael L, Daigle, Denis M, Mayer, Stanislas, Mallik, Debasis, Hughes, Donald W, Jackson, Sean G, Sulek, Margaret, Organ, Michael G, Brown, Eric D, Junop, Murray S

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YjeQ, an Essential, Conserved, Uncharacterized Protein from Escherichia coli, Is an Unusual GTPase with Circularly Permuted G-Motifs and Marked Burst Kinetics von Daigle, Denis M, Rossi, Laura, Berghuis, Albert M, Aravind, L, Koonin, Eugene V, Brown, Eric D

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High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate von Zolli-Juran, Michela, Cechetto, Jonathan D., Hartlen, Rebecca, Daigle, Denis M., Brown, Eric D.

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Inhibition of Aminoglycoside Antibiotic Resistance Enzymes by Protein Kinase Inhibitors von Daigle, Denis M., McKay, Geoffrey A., Wright, Gerard D.

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Multicopy Suppressors for Novel Antibacterial Compounds Reveal Targets and Drug Efflux Susceptibility von Li, Xiaoming, Zolli-Juran, Michela, Cechetto, Jonathan D., Daigle, Denis M., Wright, Gerard D., Brown, Eric D.

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Prodigious substrate specificity of AAC(6′)-APH(2′'), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci von Daigle, Denis M, Hughes, Donald W, Wright, Gerard D

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Aminoglycoside antibiotic phosphotransferases are also serine protein kinases von Daigle, Denis M, McKay, Geoffrey A, Thompson, Paul R, Wright, Gerard D

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