Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90) von Yao, Lianbin, Ohlson, Sten, Dymock, Brian W.

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GYY4137, a novel water-soluble, H2S-releasing molecule von Rose, Peter, Dymock, Brian W, Moore, Philip K

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Hydrogen sulfide promotes adipogenesis in 3T3L1 cells von Tsai, Chin-Yi, Peh, Meng Teng, Feng, Wei, Dymock, Brian William, Moore, Philip Keith

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A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo von Huang, Caleb Weihao, Feng, Wei, Peh, Meng Teng, Peh, Kaye, Dymock, Brian W., Moore, Philip Keith

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Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality von Kitagawa, Mayumi, Liao, Pei-Ju, Lee, Kyung Hee, Wong, Jasmine, Shang, See Cheng, Minami, Noriaki, Sampetrean, Oltea, Saya, Hideyuki, Lingyun, Dai, Prabhu, Nayana, Diam, Go Ka, Sobota, Radoslaw, Larsson, Andreas, Nordlund, Pär, McCormick, Frank, Ghosh, Sujoy, Epstein, David M., Dymock, Brian W., Lee, Sang Hyun

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Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell... von Yang, Eugene Guorong, Mustafa, Nurulhuda, Tan, Eng Chong, Poulsen, Anders, Ramanujulu, Pondy Murugappan, Chng, Wee Joo, Yen, Jeffrey J. Y, Dymock, Brian W

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Merging of ruxolitinib and vorinostat leads to highly potent inhibitors of JAK2 and histone deacetylase 6 (HDAC6) von Yao, Lianbin, Ramanujulu, Pondy Murugappan, Poulsen, Anders, Ohlson, Sten, Dymock, Brian W.

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Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat von Yao, Lianbin, Mustafa, Nurulhuda, Tan, Eng Chong, Poulsen, Anders, Singh, Prachi, Duong-Thi, Minh-Dao, Lee, Jeannie X. T, Ramanujulu, Pondy Murugappan, Chng, Wee Joo, Yen, Jeffrey J. Y, Ohlson, Sten, Dymock, Brian W

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Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity von Feng, Wei, Teo, Xin-Yi, Novera, Wisna, Ramanujulu, Pondy Murugappan, Liang, Dong, Huang, Dejian, Moore, Philip K, Deng, Lih-Wen, Dymock, Brian W

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Predicting Tacrolimus Concentrations in the Skin of Adult Kidney Transplant Recipients: A Feasibility Study von Sartain, Felicity, Viecelli, Andrea K, Veitch, Margaret, Franklin, Michael E, Dymock, Brian W, Wells, James W, Campbell, Scott B

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Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat von Chu-Farseeva, Yu-yi, Mustafa, Nurulhuda, Poulsen, Anders, Tan, Eng Chong, Yen, Jeffrey J.Y., Chng, Wee Joo, Dymock, Brian W.

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Recently discovered EZH2 and EHMT2 (G9a) inhibitors von Soumyanarayanan, Uttara, Dymock, Brian W

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The rise of epigenetic drug discovery von Dymock, Brian W

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Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor von Soumyanarayanan, Uttara, Ramanujulu, Pondy Murugappan, Mustafa, Nurulhuda, Haider, Shozeb, Fang Nee, Adina Huey, Tong, Jie Xin, Tan, Kevin S.W., Chng, Wee Joo, Dymock, Brian W.

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Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome von Moreira, Wilfried, Santhanakrishnan, Sridhar, Dymock, Brian W, Dick, Thomas

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Discovery of the cancer cell selective dual acting anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131) von See, Cheng Shang, Kitagawa, Mayumi, Liao, Pei-Ju, Lee, Kyung Hee, Wong, Jasmine, Lee, Sang Hyun, Dymock, Brian W.

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Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome von Moreira, Wilfried, Santhanakrishnan, Sridhar, Ngan, Grace J Y, Low, Choon Bing, Sangthongpitag, Kanda, Poulsen, Anders, Dymock, Brian W, Dick, Thomas

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Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518)... von William, Anthony D, Lee, Angeline C.-H, Blanchard, Stéphanie, Poulsen, Anders, Teo, Ee Ling, Nagaraj, Harish, Tan, Evelyn, Chen, Dizhong, Williams, Meredith, Sun, Eric T, Goh, Kee Chuan, Ong, Wai Chung, Goh, Siok Kun, Hart, Stefan, Jayaraman, Ramesh, Pasha, Mohammed Khalid, Ethirajulu, Kantharaj, Wood, Jeanette M, Dymock, Brian W

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Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegans von Qabazard, Bedoor, Li, Ling, Gruber, Jan, Peh, Meng Teng, Ng, Li Fang, Kumar, Srinivasan Dinesh, Rose, Peter, Tan, Choon-Hong, Dymock, Brian W, Wei, Feng, Swain, Suresh C, Halliwell, Barry, Stürzenbaum, Stephen R, Moore, Philip K

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NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis von Eccles, Suzanne A, Massey, Andy, Raynaud, Florence I, Sharp, Swee Y, Box, Gary, Valenti, Melanie, Patterson, Lisa, de Haven Brandon, Alexis, Gowan, Sharon, Boxall, Frances, Aherne, Wynne, Rowlands, Martin, Hayes, Angela, Martins, Vanessa, Urban, Frederique, Boxall, Kathy, Prodromou, Chrisostomos, Pearl, Laurence, James, Karen, Matthews, Thomas P, Cheung, Kwai-Ming, Kalusa, Andrew, Jones, Keith, McDonald, Edward, Barril, Xavier, Brough, Paul A, Cansfield, Julie E, Dymock, Brian, Drysdale, Martin J, Finch, Harry, Howes, Rob, Hubbard, Roderick E, Surgenor, Alan, Webb, Paul, Wood, Mike, Wright, Lisa, Workman, Paul

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