The significance of mitochondrial toxicity testing in drug development von Dykens, James A., Will, Yvonne

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Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells von Will, Yvonne, Dykens, James A., Nadanaciva, Sashi, Hirakawa, Brad, Jamieson, Joseph, Marroquin, Lisa D., Hynes, James, Patyna, Shem, Jessen, Bart A.

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Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro von Dykens, James A., Jamieson, Joseph, Marroquin, Lisa, Nadanaciva, Sashi, Billis, Puja A., Will, Yvonne

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In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone von Dykens, James A., Jamieson, Joseph D., Marroquin, Lisa D., Nadanaciva, Sashi, Xu, Jinghai J., Dunn, Margaret C., Smith, Arthur R., Will, Yvonne

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Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration von Nadanaciva, Sashi, Dykens, James A., Bernal, Autumn, Capaldi, Roderick A., Will, Yvonne

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Novel Mechanisms for Estrogen-Induced Neuroprotection von Singh, Meharvan, Dykens, James A., Simpkins, James W.

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Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants von Marroquin, Lisa D., Hynes, James, Dykens, James A., Jamieson, Joseph D., Will, Yvonne

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Mitochondrial mechanisms of estrogen neuroprotection von Simpkins, James W., Yi, Kun Don, Yang, Shao-Hua, Dykens, James A.

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Strategies to reduce late-stage drug attrition due to mitochondrial toxicity von Dykens, James A, Marroquin, Lisa D, Will, Yvonne

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Mitochondrial Drugs Come of Age von Moos, Walter H., Dykens, James A.

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Mitochondrial mechanisms of estrogen neuroprotection von Simpkins, James W, Dykens, James A

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Isolated Cerebral and Cerebellar Mitochondria Produce Free Radicals when Exposed to Elevated Ca2+ and Na+: Implications for Neurodegeneration von Dykens, James A.

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Oxidative Damage to Human Lens Epithelial Cells in Culture: Estrogen Protection of Mitochondrial Potential, ATP, and Cell Viability von Wang, Xiaofei, Simpkins, James W, Dykens, James A, Cammarata, Patrick R

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Development of 17α-Estradiol as a Neuroprotective Therapeutic Agent: Rationale and Results from a Phase I Clinical Study von DYKENS, JAMES A., MOOS, WALTER H., HOWELL, NEIL

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OXYGEN RADICAL PRODUCTION IN THE SEA-ANEMONE ANTHOPLEURA-ELEGANTISSIMA AND ITS ENDOSYMBIOTIC ALGAE von DYKENS, JA, SHICK, JM, BENOIT, C, BUETTNER, GR, WINSTON, GW

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Review of the effects of 17α-estradiol in humans: a less feminizing estrogen with neuroprotective potential von Moos, Walter H., Dykens, James A., Nohynek, Dana, Rubinchik, Evelina, Howell, Neil

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Development and validation of a pre-clinically relevant phototoxicity screen von Gandy, Graham J, Dykens, James A, Phillips, Gareth P

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Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog von Dykens, James A., Carroll, Amy K., Wiley, Sandra, Covey, Douglas F., Cai, Zu Yun, Zhao, Lian, Wen, Rong

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A current practice for predicting ocular toxicity of systemically delivered drugs von Somps, Chris J., Greene, Nigel, Render, James A., Aleo, Michael D., Fortner, Jay H., Dykens, James A., Phillips, Gareth

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Human neutrophil (PMN) oxygen radical production and the cytoskeleton von Wiles, M E, Dykens, J A, Wright, C D

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