Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat von Dugovic, Christine, Shelton, Jonathan E, Aluisio, Leah E, Fraser, Ian C, Jiang, Xiaohui, Sutton, Steven W, Bonaventure, Pascal, Yun, Sujin, Li, Xiaorong, Lord, Brian, Dvorak, Curt A, Carruthers, Nicholas I, Lovenberg, Timothy W

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A New Class of Diamine-Based Human Histamine H3 Receptor Antagonists:  4-(Aminoalkoxy)benzylamines von Apodaca, Richard, Dvorak, Curt A, Xiao, Wei, Barbier, Ann J, Boggs, Jamin D, Wilson, Sandy J, Lovenberg, Timothy W, Carruthers, Nicholas I

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A Dipolar Cycloaddition Reaction To Access 6‑Methyl-4,5,6,7-tetrahydro‑1H‑[1,2,3]­triazolo[4,5‑c]­pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Anta... von Chrovian, Christa C, Soyode-Johnson, Akinola, Peterson, Alexander A, Gelin, Christine F, Deng, Xiaohu, Dvorak, Curt A, Carruthers, Nicholas I, Lord, Brian, Fraser, Ian, Aluisio, Leah, Coe, Kevin J, Scott, Brian, Koudriakova, Tatiana, Schoetens, Freddy, Sepassi, Kia, Gallacher, David J, Bhattacharya, Anindya, Letavic, Michael A

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Discovery of a Series of Substituted 1H‑((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators von Gelin, Christine F., Stenne, Brice, Coate, Heather, Hiscox, Afton, Soyode-Johnson, Akinola, Wall, Jessica L., Lord, Brian, Schoellerman, Jeffrey, Coe, Kevin J., Wang, Kai, Alcázar, Jesus, Chrovian, Christa C., Dvorak, Curt A., Carruthers, Nicholas I., Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A.

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Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT7/2 inhibitors leading to the identification of a clinical candidate von Dvorak, Curt A., Rudolph, Dale A., Nepomuceno, Diane, Dvorak, Lisa, Lord, Brian, Fraser, Ian, Bonaventure, Pascal, Lovenberg, Timothy, Carruthers, Nicholas I.

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Discovery of a Series of Substituted 1 H -((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators von Gelin, Christine F, Stenne, Brice, Coate, Heather, Hiscox, Afton, Soyode-Johnson, Akinola, Wall, Jessica L, Lord, Brian, Schoellerman, Jeffrey, Coe, Kevin J, Wang, Kai, Alcázar, Jesus, Chrovian, Christa C, Dvorak, Curt A, Carruthers, Nicholas I, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A

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4‑Methyl-6,7-dihydro‑4H‑triazolo[4,5‑c]­pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate... von Letavic, Michael A, Savall, Brad M, Allison, Brett D, Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A, Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I, Ceusters, Marc, Coe, Kevin J, Dvorak, Curt A, Fraser, Ian C, Gelin, Christine F, Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W, Otieno, Monicah A, Schoetens, Freddy, Swanson, Devin M, Wang, Qi, Wickenden, Alan D, Bhattacharya, Anindya

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Diamine-based human histamine H3 receptor antagonists: (4-Aminobutyn-1-yl)benzylamines von DVORAK, Curt A, APODACA, Richard, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I, WEI XIAO, JABLONOWSKI, Jill A, BONAVENTURE, Pascal, DUGOVIC, Christine, SHELTON, Jonathan, LORD, Brian, MILLER, Kirsten, DVORAK, Lisa K

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Catalysis of benzoin condensation by conformationally-restricted chiral bicyclic thiazolium salts von Dvorak, Curt A, Rawal, Viresh H

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Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin‑1 Antagonists: Discovery of JNJ-54717793 von Préville, Cathy, Bonaventure, Pascal, Koudriakova, Tatiana, Lord, Brian, Nepomuceno, Diane, Rizzolio, Michele, Mani, Neelakandha, Coe, Kevin J, Ndifor, Anthony, Dugovic, Christine, Dvorak, Curt A, Coate, Heather, Pippel, Daniel J, Fitzgerald, Anne, Allison, Brett, Lovenberg, Timothy W, Carruthers, Nicholas I, Shireman, Brock T

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Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor von Dvorak, Curt A, Coate, Heather, Nepomuceno, Diane, Wennerholm, Michelle, Kuei, Chester, Lord, Brian, Woody, David, Bonaventure, Pascal, Liu, Changlu, Lovenberg, Timothy, Carruthers, Nicholas I

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Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects von Dvorak, Curt A, Liu, Changlu, Shelton, Jonathan, Kuei, Chester, Sutton, Steven W, Lovenberg, Timothy W, Carruthers, Nicholas I

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The First Potent and Selective Non-Imidazole Human Histamine H4 Receptor Antagonists von Jablonowski, Jill A, Grice, Cheryl A, Chai, Wenying, Dvorak, Curt A, Venable, Jennifer D, Kwok, Annette K, Ly, Kiev S, Wei, Jianmei, Baker, Sherry M, Desai, Pragnya J, Jiang, Wen, Wilson, Sandy J, Thurmond, Robin L, Karlsson, Lars, Edwards, James P, Lovenberg, Timothy W, Carruthers, Nicholas I

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Preparation and Biological Evaluation of Indole, Benzimidazole, and Thienopyrrole Piperazine Carboxamides:  Potent Human Histamine H4 Antagonists von Venable, Jennifer D, Cai, Hui, Chai, Wenying, Dvorak, Curt A, Grice, Cheryl A, Jablonowski, Jill A, Shah, Chandra R, Kwok, Annette K, Ly, Kiev S, Pio, Barbara, Wei, Jianmei, Desai, Pragnya J, Jiang, Wen, Nguyen, Steven, Ling, Ping, Wilson, Sandy J, Dunford, Paul J, Thurmond, Robin L, Lovenberg, Timothy W, Karlsson, Lars, Carruthers, Nicholas I, Edwards, James P

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Polypharmacology of Small-Molecule Modulators of the 5-Lipoxygenase Activating Protein (FLAP) Observed via a High-throughput Lipidomics Platform von Song, Jiao, Liu, Xuejun, Zhu, Jian, Tootoonchi, Mandana, Keith, John M., Meduna, Steven P., Dvorak, Curt A., Eccles, Wendy, Krawczuk, Paul J., Blevitt, Jonathan M., Wu, Jiejun, Rao, Navin L., Lebsack, Alec D., Milla, Marcos E.

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Palladium-Catalyzed Coupling of Pyrazole Triflates with Arylboronic Acids von Dvorak, Curt A, Rudolph, Dale A, Ma, Sandy, Carruthers, Nicholas I

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The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y2 receptor von Swanson, Devin M., Wong, Victoria D., Jablonowski, Jill A., Shah, Chandra, Rudolph, Dale A., Dvorak, Curt A., Seierstad, Mark, Dvorak, Lisa K., Morton, Kirsten, Nepomuceno, Diane, Atack, John R., Bonaventure, Pascal, Lovenberg, Timothy W., Carruthers, Nicholas I.

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Novel tetrahydropyrido[3,2-c]pyrroles as 5-HT7 antagonists von Rudolph, Dale A., Dvorak, Curt A., Dvorak, Lisa, Nepomuceno, Diane, Bonaventure, Pascal, Lovenberg, Timothy W., Carruthers, Nicholas I.

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The Synthesis of Streptogramin Antibiotics: (−)-Griseoviridin and Its C-8 Epimer von Dvorak, Curt A., Schmitz, William D., Poon, Daniel J., Pryde, David C., Lawson, Jon P., Amos, Richard A., Meyers, Albert I.

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Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX 2R) antagonists von McAtee, Laura C, Sutton, Steven W, Rudolph, Dale A, Li, Xiaobing, Aluisio, Leah E, Phuong, Victor K, Dvorak, Curt A, Lovenberg, Timothy W, Carruthers, Nicholas I, Jones, Todd K

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