Human Thymidylate Synthase Is in the Closed Conformation When Complexed with dUMP and Raltitrexed, an Antifolate Drug von Phan, Jason, Koli, Sangita, Minor, Wladek, Dunlap, R. Bruce, Berger, Sondra H, Lebioda, Lukasz

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Structure of Human Thymidylate Synthase Suggests Advantages of Chemotherapy with Noncompetitive Inhibitors von Phan, J, Steadman, D J, Koli, S, Ding, W C, Minor, W, Dunlap, R B, Berger, S H, Lebioda, L

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Probing an Acyl Enzyme of Selenosubtilisin by Raman Spectroscopy von O'Connor, M. J, Dunlap, R. B, Odom, J. D, Hilvert, D, Pusztai-Carey, M, Shenoy, B. C, Carey, P. R

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Studies of 5-fluorodeoxyuridine 5'-monophosphate binding to carboxypeptidase A-inactivated thymidylate synthase from Lactobacillus casei von Cisneros, R.J., Zapf, J.W., Dunlap, R.B.

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Biphasic binding of 5-fluoro-2'-deoxyuridylate to human thymidylate synthase von Reilly, R T, Barbour, K W, Dunlap, R B, Berger, F G

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Correction for light absorption in fluorescence studies of protein-ligand interactions von Birdsall, Berry, King, Rodney W., Wheeler, Miriam R., Lewis, Charles A., Goode, Scott R., Dunlap, R.Bruce, Roberts, Gordon C.K.

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Characterization of a novel form of thymidylate synthase: A heterodimer isolated after specific chemical modification of the immobilized native enzyme von Bradshaw, Timothy P, Dunlap, R. Bruce

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Evidence for the existence of covalent nucleotide-thymidylate synthase complexes, identification of site of attachment, and enhancement by folates von Moore, M A, Ahmed, F, Dunlap, R B

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Substitution of glutamine for glutamic acid-58 in Escherichia coli thymidylate synthase results in pronounced decreases in catalytic activity and ligand binding von Zapf, James W, Weir, Mary S, Emerick, Victoria, Villafranca, J. E, Dunlap, R. Bruce

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Synthesis of novel tellurium containing analogues of choline and acetylcholine and their quantitation by pyrolysis-gas chromatography-mass spectrometry von Harris, S.E., Silks, L.A., Dunlap, R.B., Odom, J.D., Kosh, J.W.

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Catalytic Cysteine of Thymidylate Synthase Is Activated upon Substrate Binding von Phan, Jason, Mahdavian, Elahe, Nivens, Michael C, Minor, Wladek, Berger, Sondra, Spencer, H. Trent, Dunlap, R. Bruce, Lebioda, Lukasz

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Thymidylate synthetase from amethopterin- resistant Lactobacillus casei von Huennekens, Frank M, Dunlap, R. B, Harding, Nigel G. L

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Trapping and partial characterization of an adduct postulated to be the covalent catalytic ternary complex of thymidylate synthase von Moore, Mark A, Ahmed, Faizy, Dunlap, R. Bruce

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Efficient synthesis of mouse thymidylate synthase in Escherichia coli von Haichao, Zhang, Cisneros, Ralph J., Dunlap, R.Bruce, Johnson, Lee F.

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Kinetic Studies on Drug-Resistant Variants of Escherichia coli Thymidylate Synthase: Functional Effects of Amino Acid Substitutions at Residue 4 von Mahdavian, Elahe, Spencer, H.Trent, Dunlap, R.Bruce

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Synthesis of novel selenium-containing choline and acetylcholine analogues and their quantitation using a pyrolysis—gas chromatography—mass spectrometry assay von Terry, A.V., Silks, Louis A., Dunlap, R.B., Odom, J.D., Kosh, J.W.

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A Hydroxyl Group at Residue 216 Is Essential for Catalysis by Human Thymidylate Synthase von Williams, Angela W, Dunlap, R. Bruce, Berger, Sondra H

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Site-directed mutagenesis of mouse thymidylate synthase: Alteration of Arg44 to Val44 in a conserved loop guarding the active site has striking effects on catalysis and nucleotide... von Zhang, Haichao, Cisneros, Ralph J., Deng, Wanleng, Johnson, Lee F., Dunlap, R.Bruce

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A Structural Role for Glutamine 214 in Human Thymidylate Synthase von Steadman, David J, Zhao, Pei-Shan, Spencer, H. Trent, Dunlap, R. Bruce, Berger, Sondra H

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Substitution at Residue 214 of Human Thymidylate Synthase Alters Nucleotide Binding and Isomerization of Ligand−Protein Complexes von Steadman, David J, Spencer, H. Trent, Dunlap, R. Bruce, Berger, Sondra H

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