Engineered lentiviral vector targeting astrocytes In vivo von Colin, Angélique, Faideau, Mathilde, Dufour, Noelle, Auregan, Gwennaelle, Hassig, Raymonde, Andrieu, Thibault, Brouillet, Emmanuel, Hantraye, Philippe, Bonvento, Gilles, Déglon, Nicole

Volltext

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin von Benchoua, Alexandra, Trioulier, Yaël, Zala, Diana, Gaillard, Marie-Claude, Lefort, Nathalie, Dufour, Noelle, Saudou, Frederic, Elalouf, Jean-Marc, Hirsch, Etienne, Hantraye, Philippe, Déglon, Nicole, Brouillet, Emmanuel

Volltext

Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease von NASCIMENTO-FERREIRA, Isabel, SANTOS-FERREIRA, Tiago, PEREIRA DE ALMEIDA, Luís, SOUSA-FERREIRA, Lígia, AUREGAN, Gwennaëlle, ONOFRE, Isabel, ALVES, Sandro, DUFOUR, Noëlle, COLOMER GOULD, Veronica F, KOEPPEN, Arnulf, DEGLON, Nicole

Volltext

Huntingtin lowering impairs the maturation and synchronized synaptic activity of human cortical neuronal networks derived from induced pluripotent stem cells von Louçã, Mathilde, El Akrouti, Donya, Lemesle, Aude, Louessard, Morgane, Dufour, Noëlle, Baroin, Chloé, de la Fouchardière, Aurore, Cotter, Laurent, Jean-Jacques, Hélène, Redeker, Virginie, Perrier, Anselme L.

Volltext

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease von Alves, Sandro, Régulier, Etienne, Nascimento-Ferreira, Isabel, Hassig, Raymonde, Dufour, Noelle, Koeppen, Arnulf, Carvalho, Ana Luísa, Simões, Sérgio, de Lima, Maria C. Pedroso, Brouillet, Emmanuel, Gould, Veronica Colomer, Déglon, Nicole, de Almeida, Luís Pereira

Volltext

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies von Dujardin, Simon, Lécolle, Katia, Caillierez, Raphaëlle, Bégard, Séverine, Zommer, Nadège, Lachaud, Cédrick, Carrier, Sébastien, Dufour, Noëlle, Aurégan, Gwennaëlle, Winderickx, Joris, Hantraye, Philippe, Déglon, Nicole, Colin, Morvane, Buée, Luc

Volltext

Reactive astrocytes promote proteostasis in Huntington's disease through the JAK2-STAT3 pathway von Abjean, Laurene, Ben Haim, Lucile, Riquelme-Perez, Miriam, Gipchtein, Pauline, Derbois, Céline, Palomares, Marie-Ange, Petit, Fanny, Hérard, Anne-Sophie, Gaillard, Marie-Claude, Guillermier, Martine, Gaudin-Guérif, Mylène, Aurégan, Gwennaëlle, Sagar, Nisrine, Héry, Cameron, Dufour, Noëlle, Robil, Noémie, Kabani, Mehdi, Melki, Ronald, De la Grange, Pierre, Bemelmans, Alexis P, Bonvento, Gilles, Deleuze, Jean-François, Hantraye, Philippe, Flament, Julien, Bonnet, Eric, Brohard, Solène, Olaso, Robert, Brouillet, Emmanuel, Carrillo-de Sauvage, Maria-Angeles, Escartin, Carole

Volltext

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo von Cresto, Noémie, Gaillard, Marie-Claude, Gardier, Camille, Gubinelli, Francesco, Diguet, Elsa, Bellet, Déborah, Legroux, Laurine, Mitja, Julien, Auregan, Gwenaëlle, Guillermier, Martine, Josephine, Charlène, Jan, Caroline, Dufour, Noëlle, Joliot, Alain, Hantraye, Philippe, Bonvento, Gilles, Déglon, Nicole, Bemelmans, Alexis-Pierre, Cambon, Karine, Liot, Géraldine, Brouillet, Emmanuel

Volltext

Sustained effects of nonallele-specific Huntingtin silencing von Drouet, Valérie, Perrin, Valérie, Hassig, Raymonde, Dufour, Noëlle, Auregan, Gwennaelle, Alves, Sandro, Bonvento, Gilles, Brouillet, Emmanuel, Luthi-Carter, Ruth, Hantraye, Philippe, Déglon, Nicole

Volltext

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin von Galvan, Laurie, Francelle, Laetitia, Gaillard, Marie-Claude, de Longprez, Lucie, Carrillo-de Sauvage, Maria-Angeles, Liot, Géraldine, Cambon, Karine, Stimmer, Lev, Luccantoni, Sophie, Flament, Julien, Valette, Julien, de Chaldée, Michel, Auregan, Gwenaelle, Guillermier, Martine, Joséphine, Charlène, Petit, Fanny, Jan, Caroline, Jarrige, Margot, Dufour, Noëlle, Bonvento, Gilles, Humbert, Sandrine, Saudou, Frédéric, Hantraye, Philippe, Merienne, Karine, Bemelmans, Alexis-Pierre, Perrier, Anselme L, Déglon, Nicole, Brouillet, Emmanuel

Volltext

The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo von Cresto, Noemie, Gardier, Camille, Gaillard, Marie-Claude, Gubinelli, Francesco, Roost, Pauline, Molina, Daniela, Josephine, Charlene, Dufour, Noelle, Auregan, Gwenaelle, Guillermier, Martine, Bernier, Sueva, Jan, Caroline, Gipchtein, Pauline, Hantraye, Philippe, Chartier-Harlin, Marie-Christine, Bonvento, Gilles, Van Camp, Nadja, Taymans, Jean-Marc, Cambon, Karine, Liot, Geraldine, Bemelmans, Alexis-Pierre, Brouillet, Emmanuel

Volltext

Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease von Francelle, Laetitia, Galvan, Laurie, Gaillard, Marie-Claude, Guillermier, Martine, Houitte, Diane, Bonvento, Gilles, Petit, Fanny, Jan, Caroline, Dufour, Noëlle, Hantraye, Philippe, Elalouf, Jean-Marc, De Chaldée, Michel, Déglon, Nicole, Brouillet, Emmanuel

Volltext

Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant von Qamar Saeed, Muhammad, Dufour, Noelle, Bartholmae, Cynthia, Sieranska, Urzula, Knopf, Malaika, Thierry, Eloïse, Thierry, Sylvain, Delelis, Olivier, Grandchamp, Nicolas, Pilet, Héloïse, Ravassard, Philippe, Massonneau, Julie, Pflumio, Françoise, von Kalle, Christof, Lachapelle, François, Bemelmans, Alexis-Pierre, Schmidt, Manfred, Serguera, Ché

Volltext

Silencing ataxin-3 mitigates degeneration in a rat model of Machado–Joseph disease: no role for wild-type ataxin-3? von Alves, Sandro, Nascimento-Ferreira, Isabel, Dufour, Noëlle, Hassig, Raymonde, Auregan, Gwennaëlle, Nóbrega, Clévio, Brouillet, Emmanuel, Hantraye, Philippe, Pedroso de Lima, Maria C., Déglon, Nicole, de Almeida, Luís Pereira

Volltext

Grafts of Brain-Derived Neurotrophic Factor and Neurotrophin 3-Transduced Primate Schwann Cells Lead to Functional Recovery of the Demyelinated Mouse Spinal Cord von Girard, Christelle, Bemelmans, Alexis-Pierre, Dufour, Noelle, Mallet, Jacques, Bachelin, Corinne, Nait-Oumesmar, Brahim, Baron-Van Evercooren, Anne, Lachapelle, Francois

Volltext

Lentiviral Delivery of the Human Wild-type Tau Protein Mediates a Slow and Progressive Neurodegenerative Tau Pathology in the Rat Brain von Caillierez, Raphaëlle, Bégard, Séverine, Lécolle, Katia, Deramecourt, Vincent, Zommer, Nadège, Dujardin, Simon, Loyens, Anne, Dufour, Noëlle, Aurégan, Gwennaëlle, Winderickx, Joris, Hantraye, Philippe, Déglon, Nicole, Buée, Luc, Colin, Morvane

Volltext

Normal aging modulates the neurotoxicity of mutant huntingtin von Diguet, Elsa, Petit, Fanny, Escartin, Carole, Cambon, Karine, Bizat, Nicolas, Dufour, Noëlle, Hantraye, Philippe, Déglon, Nicole, Brouillet, Emmanuel

Volltext

Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo von Galvan, Laurie, Lepejová, Nad'a, Gaillard, Marie-Claude, Malgorn, Carole, Guillermier, Martine, Houitte, Diane, Bonvento, Gilles, Petit, Fanny, Dufour, Noëlle, Héry, Patrick, Gérard, Matthieu, Elalouf, Jean-Marc, Déglon, Nicole, Brouillet, Emmanuel, de Chaldée, Michel

Volltext

Retinal cell type expression specificity of HIV-1-derived gene transfer vectors upon subretinal injection in the adult rat: influence of pseudotyping and promoter von Bemelmans, Alexis-Pierre, Bonnel, Sébastien, Houhou, Leïla, Dufour, Noëlle, Nandrot, Emeline, Helmlinger, Dominique, Sarkis, Chamsy, Abitbol, Marc, Mallet, Jacques

Volltext

Restricted Transgene Expression in the Brain with Cell-Type Specific Neuronal Promoters von DELZOR, Aurélie, DUFOUR, Noelle, PETIT, Fanny, GUILLERMIER, Martine, HOUITTE, Diane, AUREGAN, Gwennaelle, BROUILLET, Emmanuel, HANTRAYE, Philippe, DEGLON, Nicole

Volltext