Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins von Ali, Youssif M, Ferrari, Matteo, Lynch, Nicholas J, Yaseen, Sadam, Dudler, Thomas, Gragerov, Sasha, Demopulos, Gregory, Heeney, Jonathan L, Schwaeble, Wilhelm J

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Development and characterization of narsoplimab, a selective MASP-2 inhibitor, for the treatment of lectin-pathway-mediated disorders von Dudler, Thomas, Yaseen, Sadam, Cummings, W Jason

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Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury von Mercurio, Domenico, Pischiutta, Francesca, Seminara, Serena, Tribuzio, Francesca, Lisi, Ilaria, Pasetto, Laura, Bonetto, Valentina, De Simoni, Maria-Grazia, Schwaeble, Wilhelm, Yaseen, Sadam, Dudler, Thomas, Zanier, Elisa R, Fumagalli, Stefano

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Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury von Schwaeble, Wilhelm J, Lynch, Nicholas J, Clark, James E, Marber, Michael, Samani, Nilesh J, Ali, Youssif Mohammed, Dudler, Thomas, Parent, Brian, Lhotta, Karl, Wallis, Russell, Farrar, Conrad A, Sacks, Steven, Lee, Haekyung, Zhang, Ming, Iwaki, Daisuke, Takahashi, Minoru, Fujita, Teizo, Tedford, Clark E, Stover, Cordula M

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Lectin pathway effector enzyme mannan‐binding lectin‐associated serine protease‐2 can activate native complement C3 in absence of C4 and/or C2 von Yaseen, Sadam, Demopulos, Gregory, Dudler, Thomas, Yabuki, Munehisa, Wood, Christi L., Cummings, W. Jason, Tjoelker, Larry W., Fujita, Teizo, Sacks, Steven, Garred, Peter, Andrew, Peter, Sim, Robert B., Lachmann, Peter J., Wallis, Russell, Lynch, Nicholas, Schwaeble, Wilhelm J.

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Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy von Gavriilaki, Eleni, Ho, Vincent T, Schwaeble, Wilhelm, Dudler, Thomas, Daha, Mohamed, Fujita, Teizo, Jodele, Sonata

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The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection von Ali, Youssif M, Lynch, Nicholas J, Haleem, Kashif S, Fujita, Teizo, Endo, Yuichi, Hansen, Soren, Holmskov, Uffe, Takahashi, Kazue, Stahl, Gregory L, Dudler, Thomas, Girija, Umakhanth V, Wallis, Russell, Kadioglu, Aras, Stover, Cordula M, Andrew, Peter W, Schwaeble, Wilhelm J

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Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1 von Orsini, Franca, Chrysanthou, Elvina, Dudler, Thomas, Cummings, W Jason, Takahashi, Minoru, Fujita, Teizo, Demopulos, Gregory, De Simoni, Maria-Grazia, Schwaeble, Wilhelm

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Inhibition of the lectin pathway of complement activation reduces LPS-induced acute respiratory distress syndrome in mice von Ali, Youssif M, Lynch, Nicholas J, Shaaban, Ahmed A, Rizk, Dina E, Abdel-Rahman, Shaymaa H, Khatri, Priyanka, Yabuki, Munehisa, Yaseen, Sadam, Dudler, Thomas, Demopulos, Gregory, Schwaeble, Wilhelm J

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Absence of the Lectin Activation Pathway of Complement Ameliorates Proteinuria-Induced Renal Injury von Alghadban, Samy, Kenawy, Hany I, Dudler, Thomas, Schwaeble, Wilhelm J, Brunskill, Nigel J

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Development of Pharmacodynamic Assays to Assess Ex Vivo Masp-2 Inhibition and Their Use to Characterize the Pharmacodynamics of Narsoplimab (OMS721) in Humans and Monkeys von Freeman, Jeremy, Cummings, Jason, Chuidian, Marither, Dudler, Thomas

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Identification of the Phosphorylation Sites of Cytosolic Phospholipase A2 in Agonist-stimulated Human Platelets and HeLa Cells von Börsch-Haubold, A G, Bartoli, F, Asselin, J, Dudler, T, Kramer, R M, Apitz-Castro, R, Watson, S P, Gelb, M H

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Palmitoylation of Ha-Ras Facilitates Membrane Binding, Activation of Downstream Effectors, and Meiotic Maturation in Xenopus Oocytes (∗) von Dudler, Thomas, Gelb, Michael H.

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MASP-2 and MASP-3 inhibitors block complement activation, inflammation, and microvascular stasis in a murine model of vaso-occlusion in sickle cell disease von Belcher, John D., Nguyen, Julia, Chen, Chunsheng, Abdulla, Fuad, Conglin, Ruan, Ivy, Zalaya K., Cummings, Jason, Dudler, Thomas, Vercellotti, Gregory M.

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Purification of a Protein Palmitoyltransferase that Acts on H-Ras Protein and on a C-terminal N-Ras Peptide von Liu, L, Dudler, T, Gelb, M H

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Cardioprotection by an anti-MASP-2 antibody in a murine model of myocardial infarction von Clark, James, E, Dudler, Thomas, Marber, Michael, S, Schwaeble, Wilhelm

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Utility of MASP-2 inhibition in murine models of cerebral ischemia von Orsini, Franca, Chrysanthou, Elvina, Dudler, Thomas, Cummings, Jason, Takahashi, Minoru, Fujita, Teizo, Demopulos, Gregory, De Simoni, Maria-Grazia, Schwaeble, Wilhelm

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Active Site of Bee Venom Phospholipase A2:  The Role of Histidine-34, Aspartate-64 and Tyrosine-87 von Annand, Robert R, Kontoyianni, Maria, Penzotti, Julie E, Dudler, Thomas, Lybrand, Terry P, Gelb, Michael H

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Natural and recombinant enzymatically active or inactive bee venom phospholipase A 2 has the same potency to release histamine from basophils in patients with Hymenoptera allergy von Förster, Elisabeth, Dudler b, Thomas, Gmachl, Michael, Aberer, Werner, Urbanek, Radvan, Suter, Mark

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The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection von Ali, Youssif M, Lynch, Nicholas J, Haleem, Kashif S, Fujita, Teizo, Endo, Yuichi, Hansen, Soren, Holmskov, Uffe, Takahashi, Kazue, Stahl, Gregory L, Dudler, Thomas, Girija, Umakhanth V, Wallis, Russell, Kadioglu, Aras, Stover, Cordula M, Andrew, Peter W, Schwaeble, Wilhelm J

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