The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers disease von Pentz, Rowan, Iulita, M. Florencia, Ducatenzeiler, Adriana, Bennett, David A., Cuello, A. Claudio

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A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: Proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer's pathology von Pentz, Rowan, Iulita, M. Florencia, Mikutra-Cencora, Maya, Ducatenzeiler, Adriana, Bennett, David A., Cuello, A. Claudio

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Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology von Ferretti, Maria Teresa, Allard, Simon, Partridge, Vanessa, Ducatenzeiler, Adriana, Cuello, A Claudio

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Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease von Iulita, M. Florencia, Bistué Millón, M. Beatriz, Pentz, Rowan, Aguilar, Lisi Flores, Do Carmo, Sonia, Allard, Simon, Michalski, Bernadeta, Wilson, Edward N., Ducatenzeiler, Adriana, Bruno, Martin A., Fahnestock, Margaret, Cuello, A. Claudio

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The amyloid pathology progresses in a neurotransmitter-specific manner von Bell, Karen F.S., Ducatenzeiler, Adriana, Ribeiro-da-Silva, Alfredo, Duff, Karen, Bennett, David A., Claudio Cuello, A.

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Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease von Ferretti, Maria Teresa, Bruno, Martin A, Ducatenzeiler, Adriana, Klein, William L, Cuello, A. Claudio

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The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheime’s disease von Pentz, Rowan, Iulita, M. Florencia, Ducatenzeiler, Adriana, Bennett, David A., Cuello, A. Claudio

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AF710B, an M1/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer's disease von Hall, Hélène, Iulita, Maria Florencia, Gubert, Palma, Flores Aguilar, Lisi, Ducatenzeiler, Adriana, Fisher, Abraham, Cuello, Augusto Claudio

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Neuronal driven pre-plaque inflammation in a transgenic rat model of Alzheimer's disease von Hanzel, Cecilia E, Pichet-Binette, Alexa, Pimentel, Luisa S.B, Iulita, M. Florencia, Allard, Simon, Ducatenzeiler, Adriana, Do Carmo, Sonia, Cuello, A. Claudio

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Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease von Wilson, Edward N, Abela, Andrew R, Do Carmo, Sonia, Allard, Simon, Marks, Adam R, Welikovitch, Lindsay A, Ducatenzeiler, Adriana, Chudasama, Yogita, Cuello, A Claudio

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Early loss of locus coeruleus innervation promotes cognitive and neuropathological changes before amyloid plaque deposition in a transgenic rat model of Alzheimer's disease von Flores‐Aguilar, Lisi, Hall, Hélène, Orciani, Chiara, Foret, Morgan K., Kovecses, Olivia, Ducatenzeiler, Adriana, Cuello, A. Claudio

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Nerve growth factor (NGF) pathway biomarkers in Down syndrome prior to and after the onset of clinical Alzheimer's disease: A paired CSF and plasma study von Pentz, Rowan, Iulita, M. Florencia, Ducatenzeiler, Adriana, Videla, Laura, Benejam, Bessy, Iragui, María Carmona, Blesa, Rafael, Lleó, Alberto, Fortea, Juan, Cuello, A. Claudio

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Rescue of Early bace-1 and Global DNA Demethylation by S-Adenosylmethionine Reduces Amyloid Pathology and Improves Cognition in an Alzheimer’s Model von Do Carmo, Sonia, Hanzel, Cecilia E., Jacobs, Marie L., Machnes, Ziv, Iulita, M. Florencia, Yang, Jingyun, Yu, Lei, Ducatenzeiler, Adriana, Danik, Marc, Breuillaud, Lionel S., Bennett, David A., Szyf, Moshe, Cuello, A. Claudio

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Hippocampal Proteomic Analysis Reveals Distinct Pathway Deregulation Profiles at Early and Late Stages in a Rat Model of Alzheimer’s-Like Amyloid Pathology von Do Carmo, Sonia, Crynen, Gogce, Paradis, Tiffany, Reed, Jon, Iulita, M. Florencia, Ducatenzeiler, Adriana, Crawford, Fiona, Cuello, A. Claudio

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Identification and Preliminary Validation of a Plasma Profile Associated with Cognitive Decline in Dementia and At-risk Individuals: A Retrospective Cohort Analysis (P3.1-029) von Iulita, M Florencia, Ganesh, Aravind, Pentz, Rowan, Aguilar, Lisi Flores, Gubert, Palma, Ducatenzeiler, Adriana, Christie, Sharon, Wilcock, Gordon K., Cuello, A. Claudio

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PRO-COGNITIVE AND ANTI-INFLAMMATORY EFFECTS OF AF710B, A MIXED M1 MUSCARINIC/SIGMA-1 RECEPTOR AGONIST, IN THE MCGILL-R-THY1-APP RAT MODEL OF HUMAN AD-LIKE AMYLOID PATHOLOGY von Hall, Helene, Iulita, Maria Florencia, Ducatenzeiler, Adriana, Fisher, Abraham, Cuello, A. Claudio

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P4‐013: Pro‐Cognitive and Anti‐Inflammatory Effects of Af710B, a Mixed M1 Muscarinic/Sigma‐1 Receptor Agonist, in the Mcgill‐R‐Thy1‐App Rat Model of Human Ad‐Like Amyloid Pathology... von Hall, Helene, Iulita, Maria Florencia, Ducatenzeiler, Adriana, Fisher, Abraham, Cuello, A. Claudio

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Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study von Iulita, M Florencia, Allard, Simon, Richter, Luise, Munter, Lisa-Marie, Ducatenzeiler, Adriana, Weise, Christoph, Do Carmo, Sonia, Klein, William L, Multhaup, Gerhard, Cuello, A Claudio

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O2‐02‐01: Dna Demethylation and Remethylation in Alzheimer’s Pathology von Carmo, Sonia Do, Jacobs, Marie L., Machnes, Ziv, Iulita, M. Florencia, Yang, Jingyun, Yu, Lei, Ducatenzeiler, Adriana, Wilson, Edward N., Bennett, David A., Szyf, Moshe, Cuello, A. Claudio

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P3‐046: NP03 Inhibits Bace1 and GSK‐3B for the Prevention of Early Alzheimer’s‐Like Amyloid Neuropathology in Transgenic Rats von Wilson, Edward N., Carmo, Sonia Do, Iulita, M. Florencia, Allard, Simon, Marks, Adam R., Windheim, Joseph, Ducatenzeiler, Adriana, Cuello, A. Claudio

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