Rimegepant, an Oral Calcitonin Gene–Related Peptide Receptor Antagonist, for Migraine von Lipton, Richard B, Croop, Robert, Stock, Elyse G, Stock, David A, Morris, Beth A, Frost, Marianne, Dubowchik, Gene M, Conway, Charles M, Coric, Vladimir, Goadsby, Peter J

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Antibody drug conjugates for treatment of breast cancer: Novel targets and diverse approaches in ADC design von Trail, Pamela A, Dubowchik, Gene M, Lowinger, Timothy B

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Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core von Sivaprakasam, Prasanna, Han, Xiaojun, Civiello, Rita L, Jacutin-Porte, Swanee, Kish, Kevin, Pokross, Matt, Lewis, Hal A, Ahmed, Nazia, Szapiel, Nicolas, Newitt, John A, Baldwin, Eric T, Xiao, Hong, Krause, Carol M, Park, Hyunsoo, Nophsker, Michelle, Lippy, Jonathan S, Burton, Catherine R, Langley, David R, Macor, John E, Dubowchik, Gene M

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Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success von Dubowchik, Gene M, Conway, Charles M, Xin, Alison W

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Discovery of (5S,6S,9R)‑5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro‑5H‑cyclohepta[b]pyridin-9-yl 4‑(2-oxo-2,3-dihydro‑1H‑imidazo[4,5‑b]pyridin-1-yl)piperidine-1-carboxylate (... von Luo, Guanglin, Chen, Ling, Conway, Charles M., Denton, Rex, Keavy, Deborah, Signor, Laura, Kostich, Walter, Lentz, Kimberley A., Santone, Kenneth S., Schartman, Richard, Browning, Marc, Tong, Gary, Houston, John G., Dubowchik, Gene M., Macor, John E.

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Cathepsin B-Labile Dipeptide Linkers for Lysosomal Release of Doxorubicin from Internalizing Immunoconjugates:  Model Studies of Enzymatic Drug Release and Antigen-Specific In Vitr... von Dubowchik, Gene M, Firestone, Raymond A, Padilla, Linda, Willner, David, Hofstead, Sandra J, Mosure, Kathleen, Knipe, Jay O, Lasch, Shirley J, Trail, Pamela A

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Design, Structure–Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2‑b]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors von Hartz, Richard A., Ahuja, Vijay T., Sivaprakasam, Prasanna, Xiao, Hong, Krause, Carol M., Clarke, Wendy J., Kish, Kevin, Lewis, Hal, Szapiel, Nicolas, Ravirala, Ramu, Mutalik, Sayali, Nakmode, Deepa, Shah, Devang, Burton, Catherine R., Macor, John E., Dubowchik, Gene M.

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Structure–activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors... von Luo, Guanglin, Chen, Ling, Jacutin-Porte, Swanee, Han, Ying, Burton, Catherine R., Xiao, Hong, Krause, Carol M., Cao, Yang, Liu, Nengyin, Kish, Kevin, Lewis, Hal A., Macor, John E., Dubowchik, Gene M.

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Discovery of 2‑(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase‑3 (GSK-3) Inhibitors von Hartz, Richard A., Ahuja, Vijay T., Luo, Guanglin, Chen, Ling, Sivaprakasam, Prasanna, Xiao, Hong, Krause, Carol M., Clarke, Wendy J., Xu, Songmei, Tokarski, John S., Kish, Kevin, Lewis, Hal, Szapiel, Nicolas, Ravirala, Ramu, Mutalik, Sayali, Nakmode, Deepa, Shah, Devang, Burton, Catherine R., Macor, John E., Dubowchik, Gene M.

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Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase‑3 Inhibitors von Luo, Guanglin, Chen, Ling, Burton, Catherine R, Xiao, Hong, Sivaprakasam, Prasanna, Krause, Carol M, Cao, Yang, Liu, Nengyin, Lippy, Jonathan, Clarke, Wendy J, Snow, Kimberly, Raybon, Joseph, Arora, Vinod, Pokross, Matt, Kish, Kevin, Lewis, Hal A, Langley, David R, Macor, John E, Dubowchik, Gene M

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Calcitonin gene-related peptide (CGRP) receptor antagonists: Heterocyclic modification of a novel azepinone lead von Luo, Guanglin, Jiang, Xiang-Jun, Chen, Ling, Conway, Charles M., Gulianello, Michael, Kostich, Walter, Keavy, Deborah, Signor, Laura J., Chen, Ping, Davis, Carl, Whiterock, Valerie J., Schartman, Richard, Widmann, Kimberly A., Macor, John E., Dubowchik, Gene M.

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Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists von Mercer, Stephen E., Chaturvedula, Prasad V., Conway, Charles M., Cook, Deborah A., Davis, Carl D., Pin, Sokhom S., Macci, Robert, Schartman, Richard, Signor, Laura J., Widmann, Kimberly A., Whiterock, Valerie J., Chen, Ping, Xu, Cen, Herbst, John J., Kostich, Walter A., Thalody, George, Macor, John E., Dubowchik, Gene M.

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Asymmetric Synthesis of Heterocyclic Analogues of a CGRP Receptor Antagonist for Treating Migraine von Luo, Guanglin, Chen, Ling, Conway, Charles M., Kostich, Walter, Macor, John E., Dubowchik, Gene M.

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Asymmetric Synthesis of the Major Metabolite of a Calcitonin Gene-Related Peptide Receptor Antagonist and Mechanism of Epoxide Hydrogenolysis von Luo, Guanglin, Chen, Ling, Conway, Charles M, Kostich, Walter, Johnson, Benjamin M, Ng, Alicia, Macor, John E, Dubowchik, Gene M

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Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs von Dubowchik, Gene M, Walker, Michael A

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Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent h... von Chaturvedula, Prasad V., Mercer, Stephen E., Pin, Sokhom S., Thalody, George, Xu, Cen, Conway, Charlie M., Keavy, Deborah, Signor, Laura, Cantor, Glenn H., Mathias, Neil, Moench, Paul, Denton, Rex, Macci, Robert, Schartman, Richard, Whiterock, Valerie, Davis, Carl, Macor, John E., Dubowchik, Gene M.

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Synthesis of an immunoconjugate of camptothecin von Walker, Michael A, Dubowchik, Gene M, Hofstead, Sandra J, Trail, Pamela A, Firestone, Raymond A

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Synthesis and SAR of calcitonin gene-related peptide (CGRP) antagonists containing substituted aryl-piperazines and piperidines von Civiello, Rita L., Han, Xiaojun, Beno, Brett R., Chaturvedula, Prasad V., Herbst, John J., Xu, Cen, Conway, Charles M., Macor, John E., Dubowchik, Gene M.

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Induction of cell death by the lysosomotropic detergent MSDH von Li, Wei, Yuan, XiMing, Nordgren, Gunnar, Dalen, Helge, Dubowchik, Gene M., Firestone, Raymond A., Brunk, Ulf T.

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Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor von Chaturvedula, Prasad V., Pin, Sokhom, Tholady, George, Conway, Charlie M., Macor, John E., Dubowchik, Gene M.

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