Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis von Chipuk, Jerry E., Kuwana, Tomomi, Bouchier-Hayes, Lisa, Droin, Nathalie M., Newmeyer, Donald D., Schuler, Martin, Green, Douglas R.

Volltext

A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression von Marty, C, Lacout, C, Droin, N, Le Couédic, J-P, Ribrag, V, Solary, E, Vainchenker, W, Villeval, J-L, Plo, I

Volltext

Whole exome sequencing in molecular diagnostics of cancer decreases over time: evidence from a cost analysis in the French setting von Bayle, Arnaud, Droin, N., Besse, B., Zou, Z., Boursin, Y., Rissel, S., Solary, E., Lacroix, L., Rouleau, E., Borget, I., Bonastre, J.

Volltext

SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias von Damm, F, Itzykson, R, Kosmider, O, Droin, N, Renneville, A, Chesnais, V, Gelsi-Boyer, V, de Botton, S, Vey, N, Preudhomme, C, Clavert, A, Delabesse, E, Park, S, Birnbaum, D, Fontenay, M, Bernard, O A, Solary, E

Volltext

DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice von Scourzic, L, Couronné, L, Pedersen, M T, Della Valle, V, Diop, M, Mylonas, E, Calvo, J, Mouly, E, Lopez, C K, Martin, N, Fontenay, M, Bender, A, Guibert, S, Dubreuil, P, Dessen, P, Droin, N, Pflumio, F, Weber, M, Gaulard, P, Helin, K, Mercher, T, Bernard, O A

Volltext

Mutation of the colony-stimulating factor-3 receptor gene is a rare event with poor prognosis in chronic myelomonocytic leukemia von Kosmider, O, Itzykson, R, Chesnais, V, Lasho, T, Laborde, R, Knudson, R, Gauthier, A, Merlevede, J, Ades, L, Morabito, M, Fontenay, M, Tefferi, A, Droin, N, Solary, E

Volltext

DNMT3AR882H mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice von Scourzic, L, Couronné, L, Pedersen, M T, Della Valle, V, Diop, M, Mylonas, E, Calvo, J, Mouly, E, Lopez, C K, Martin, N, Fontenay, M, Bender, A, Guibert, S, Dubreuil, P, Dessen, P, Droin, N, Pflumio, F, Weber, M, Gaulard, P, Helin, K, Mercher, T, Bernard, O A

Volltext

Use of the 46/1 haplotype to model JAK2(V617F) clonal architecture in PV patients: clonal evolution and impact of IFNα treatment von Hasan, S, Cassinat, B, Droin, N, Le Couedic, J P, Favale, F, Monte-Mor, B, Lacout, C, Fontenay, M, Dosquet, C, Chomienne, C, Solary, E, Villeval, J L, Casadevall, N, Kiladjian, J J, Vainchenker, W, Plo, I

Volltext

Condé-sur-l'Escaut (Nord). Château de l'Arsenal von Droin, Lionel

Volltext

Positive feedback regulation of PLC gamma 1/Ca2+ signaling by PKC theta in restimulated T cells via a Tec kinase-dependent pathway von Altman, A., Kaminski, S., Busuttil, V., Droin, N., Hu, J. R., Tadevosyan, Y., Hipskind, R. A., Villalba, Martin

Volltext

Egr Family Members Regulate Nonlymphoid Expression of Fas Ligand, TRAIL, and Tumor Necrosis Factor during Immune Responses von Droin, Nathalie M., Pinkoski, Michael J., Dejardin, Emmanuel, Green, Douglas R.

Volltext

Positive and negative regulation of apoptotic pathways by cytotoxic agents in hematological malignancies von SOLARY, E, DROIN, N, BETTAIEB, A, CORCOS, L, DIMANCHE-BOITREL, M-T, GARRIDO, C

Volltext

Cytokine-like protein 1–induced survival of monocytes suggests a combined strategy targeting MCL1 and MAPK in CMML von Sevin, Margaux, Debeurme, Franck, Laplane, Lucie, Badel, Séverine, Morabito, Margot, Newman, Hanna L., Torres-Martin, Miguel, Yang, Qin, Badaoui, Bouchra, Wagner-Ballon, Orianne, Saada, Véronique, Sélimoglu-Buet, Dorothée, Kraus-Berthier, Laurence, Banquet, Sébastien, Derreal, Alix, Fenaux, Pierre, Itzykson, Raphael, Braun, Thorsten, Etienne, Gabriel, Berthon, Celine, Thépot, Sylvain, Kepp, Oliver, Kroemer, Guido, Padron, Eric, Figueroa, Maria E., Droin, Nathalie, Solary, Eric

Volltext

Condé-sur-L’escaut (Nord). Château de l’arsenal, rue du munitionnaire von Droin, Lionel

Volltext

Topic: AS04-MDS Biology and Pathogenesis/AS04b-Clonal diversity & evolution: IMPROVING THE CLONAL EVOLUTION MODEL: THE CASE OF CMML von Laplane, L., Selimoglu-Buet, D., Renneville, A., Willekens, C., Droin, N., Porteu, F., Perie, L., Solary, E.

Volltext

HETEROCHROMATIN CHANGES IN HSCS FROM CMML PATIENTS CONFER SENSITIVITY TO THE COMBINATION OF G9A/GLP INHIBITORS AND DNA HYPOMETHYLATING AGENTS VIA DEREPRESSION OF RETROELEMENTS von Hidaoui, D., Alcazer, V., Chelbi, R., Droin, N., Depil, S., Elvira-Matelot, E., Solary, E., Porteu, F.

Volltext

343MO Unraveling the mechanisms of action and resistance to trastuzumab deruxtecan (T-DXd): Supplementary biomarker analyses from DAISY trial von Mosele, M.F., Lusque, A., Dieras, V.C., Deluche, E., Ducoulombier, A., Pistilli, B., Bachelot, T., Viret, F., Levy, C., Pradat, Y.C., Signolle, N., Le Bescond, L., Tran, D., Droin, N., Kobayashi, M., Kakewaga, T., Deloger, M., Jimenez, M., Lacroix-Triki, M., André, F.

Volltext

Topic: AS04-MDS Biology and Pathogenesis/AS04a-Normal, MDS, and leukemic stem cells: CALPROTECTIN (S100A8/A9) EFFECTS ON HEALTHY CD34+ HEMATOPOIETIC STEM AND PROGENITOR CELLS ARE A... von Marchand, V., Laplane, L., Valensi, L., Boutonnet, H., Selimoglu-Buet, D., Plo, I., Renneville, A., Elvira-Matelot, E., Porteu, F., Droin, N., Fontenay, M., Solary, E.

Volltext

1672P Tumor and immune cell dynamics at single-cell resolution on combined PARP inhibition and anti-PD-L1 therapy von Vibert, J., Henon, C., Martin Romano, P., Tselikas, L., Colmet-Daage, L., Chabanon, R., Dorvault, N., Gazzah, A., Bouquet, F., Droin, N., Fizazi, K., Vasseur, D., Rouleau, E., Postel-Vinay, S.

Volltext

Condé-sur l’Escaut (Nord). Château de l’Arsenal von Droin, Lionel

Volltext