Costimulatory and coinhibitory receptors in anti-tumor immunity von Driessens, Gregory, Kline, Justin, Gajewski, Thomas F

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Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockad... von Gomes, Bruno, Driessens, Gregory, Bartlett, Derek, Cai, Danying, Cauwenberghs, Sandra, Crosignani, Stefano, Dalvie, Deepak, Denies, Sofie, Dillon, Christopher P, Fantin, Valeria R, Guo, Jie, Letellier, Marie-Claire, Li, Wenlin, Maegley, Karen, Marillier, Reece, Miller, Nichol, Pirson, Romain, Rabolli, Virginie, Ray, Chad, Streiner, Nicole, Torti, Vince R, Tsaparikos, Konstantinos, Van den Eynde, Benoit J, Wythes, Martin, Yao, Li-Chin, Zheng, Xianxian, Tumang, Joseph, Kraus, Manfred

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Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors von Schramme, Florence, Crosignani, Stefano, Frederix, Kim, Hoffmann, Delia, Pilotte, Luc, Stroobant, Vincent, Preillon, Julie, Driessens, Gregory, Van den Eynde, Benoit J

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TIGIT inhibition and lenalidomide synergistically promote antimyeloma immune responses after stem cell transplantation in mice von Minnie, Simone A, Waltner, Olivia G, Ensbey, Kathleen S, Olver, Stuart D, Collinge, Alika D, Sester, David P, Schmidt, Christine R, Legg, Samuel Rw, Takahashi, Shuichiro, Nemychenkov, Nicole S, Sekiguchi, Tomoko, Driessens, Gregory, Zhang, Ping, Koyama, Motoko, Spencer, Andrew, Holmberg, Leona A, Furlan, Scott N, Varelias, Antiopi, Hill, Geoffrey R

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74 a-TIGIT mAb belrestotug in combination with anti-PD1 induces an immunocompetent tumor microenvironment (TME) von Cuende, Julia, Ma, Stephanie, Welsby, Iain, Rosewick, Nicolas, Wald, Noemie, Vezzu, Anais, Mercier, Marjorie, Tieppo, Paola, Claes, Bart, McGrath, Yvonne, Henau, Olivier De, Driessens, Gregory, Ceppi, Maurizio, Libouban, Marion

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designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library von Takacs, Zoltan, Toups, Megan, Kollewe, Astrid, Johnson, Erik, Cuello, Luis G, Driessens, Gregory, Biancalana, Matthew, Koide, Akiko, Ponte, Cristiano G, Perozo, Eduardo, Gajewski, Thomas F, Suarez-Kurtz, Guilherme, Koide, Shohei, Goldstein, Steve A.N

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Defining the mode of tumour growth by clonal analysis von Driessens, Gregory, Beck, Benjamin, Caauwe, Amélie, Simons, Benjamin D., Blanpain, Cédric

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Long Live Sox2: Sox2 Lasts a Lifetime von Driessens, Grégory, Blanpain, Cédric

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SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma von Boumahdi, Soufiane, Driessens, Gregory, Lapouge, Gaelle, Rorive, Sandrine, Nassar, Dany, Le Mercier, Marie, Delatte, Benjamin, Caauwe, Amélie, Lenglez, Sandrine, Nkusi, Erwin, Brohée, Sylvain, Salmon, Isabelle, Dubois, Christine, Marmol, Veronique del, Fuks, Francois, Beck, Benjamin, Blanpain, Cédric

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Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8⁺ T cells von Cham, Candace M, Driessens, Gregory, O'Keefe, James P, Gajewski, Thomas F

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Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo von Zheng, Yan, Zha, Yuanyuan, Driessens, Gregory, Locke, Frederick, Gajewski, Thomas F

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A vascular niche and a VEGF–Nrp1 loop regulate the initiation and stemness of skin tumours von Beck, Benjamin, Driessens, Gregory, Goossens, Steven, Youssef, Khalil Kass, Kuchnio, Anna, Caauwe, Amélie, Sotiropoulou, Panagiota A., Loges, Sonja, Lapouge, Gaelle, Candi, Aurélie, Mascre, Guilhem, Drogat, Benjamin, Dekoninck, Sophie, Haigh, Jody J., Carmeliet, Peter, Blanpain, Cédric

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TIG-007: Study of EOS884448/GSK4428859A Alone, and in Combination with Iberdomide with or without Dexamethasone, in Participants with Relapsed or Refractory Multiple Myeloma von Moreau, Philippe, Holmberg, Leona, Meuleman, Nathalie, Graham, Philippa, De Henau, Olivier, Driessens, Gregory, McGrath, Yvonne, Lager, Joanne, Hill, Geoffrey R

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Beyond PD-1: Investigating the Therapeutic Potential of TIGIT Blockade in DLBCL von Sunseri, Nicole, Chen, Xiufen, Wald, Noemie, Preillon, Julie, Smith, Sonali M., Driessens, Gregory, Kline, Justin

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Abstract 3249: a-TIGIT mediates antitumor activity through multiple mechanisms of action involving activation of intratumor effector T cells and depletion of regulatory T cells von Preillon, Julie, Denies, Sofie, Jamart, Diane, Carter, Matthew J., Cragg, Mark S., Driessens, Gregory

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The Combination of Anti-Tigit and Lenalidomide Promotes Synergistic Myeloma-Specific Immunity after ASCT von Minnie, Simone A, Nemychenkov, Nicole S, Ensbey, Kathleen S, Schmidt, Christine R, Driessens, Gregory, Campoy, Gabriela, Takahashi, Shuichiro, Holmberg, Leona A., Hill, Geoffrey R

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Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies von Preillon, Julie, Cuende, Julia, Rabolli, Virginie, Garnero, Lucile, Mercier, Marjorie, Wald, Noémie, Pappalardo, Angela, Denies, Sofie, Jamart, Diane, Michaux, Anne-Catherine, Pirson, Romain, Pitard, Vincent, Bagot, Martine, Prasad, Shruthi, Houthuys, Erica, Brouwer, Margreet, Marillier, Reece, Lambolez, Florence, Marchante, Joäo R, Nyawouame, Florence, Carter, Mathew J, Baron-Bodo, Véronique, Marie-Cardine, Anne, Cragg, Mark, Déchanet-Merville, Julie, Driessens, Gregory, Hoofd, Catherine

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Abstract 3240: EOS884448, a high affinity fully human antibody directed against TIGIT, mediates in vitro anti-tumor activity through multiples mechanisms of action involving activa... von Cuende, Julia, Rabolli, Virginie, Nyawouame, Florence, Mercier, Marjorie, Pappalardo, Angela, Garnero, Lucile, Dechanet-Merville, Julie, Driessens, Gregory, Hoofd, Catherine

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Highly successful therapeutic vaccinations combining dendritic cells and tumor cells secreting granulocyte macrophage colony-stimulating factor von DRIESSENS, Gregory, HAMDANE, Malika, COOL, Vincent, VELU, Thierry, BRUYNS, Catherine

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Abstract 3161: Preparation of aclinical trial with a-TIGIT antagonist antibody EOS884448, which demonstrates potent preclinical activity and safe toxicology profile von Nguyen, Thi Lien-Anh, Cuende, Julia, Preillon, Julie, Garnero, Lucile, Rabolli, Virginie, Wald, Noémie, Hoofd, Catherine, Chevron, Patricia, Mercier, Marjorie, De Henau, Olivier, Bodo, Véronique, Driessens, Gregory

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