A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents von Luo, Jian, Swaminath, Gayathri, Brown, Sean P, Zhang, Jane, Guo, Qi, Chen, Michael, Nguyen, Kathy, Tran, Thanhvien, Miao, Lynn, Dransfield, Paul J, Vimolratana, Marc, Houze, Jonathan B, Wong, Simon, Toteva, Maria, Shan, Bei, Li, Frank, Zhuang, Run, Lin, Daniel C-H

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Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor von Lin, Daniel C-H, Guo, Qi, Luo, Jian, Zhang, Jane, Nguyen, Kathy, Chen, Michael, Tran, Thanh, Dransfield, Paul J, Brown, Sean P, Houze, Jonathan, Vimolratana, Marc, Jiao, Xian Yun, Wang, Yingcai, Birdsall, Nigel J M, Swaminath, Gayathri

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Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1 von Xiong, Yumei, Swaminath, Gayathri, Cao, Qiong, Yang, Li, Guo, Qi, Salomonis, Heather, Lu, Jenny, Houze, Jonathan B., Dransfield, Paul J., Wang, Yingcai, Liu, Jiwen (Jim), Wong, Simon, Schwandner, Ralf, Steger, Franziska, Baribault, Helene, Liu, Lily, Coberly, Suzanne, Miao, Lynn, Zhang, Jane, Lin, Daniel C.-H., Schwarz, Margrit

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Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles von Wang, Yingcai, Liu, Jiwen (Jim), Dransfield, Paul J, Zhu, Liusheng, Wang, Zhongyu, Du, Xiaohui, Jiao, Xianyun, Su, Yongli, Li, An-rong, Brown, Sean P, Kasparian, Annie, Vimolratana, Marc, Yu, Ming, Pattaropong, Vatee, Houze, Jonathan B, Swaminath, Gayathri, Tran, Thanhvien, Nguyen, Khanh, Guo, Qi, Zhang, Jane, Zhuang, Run, Li, Frank, Miao, Lynn, Bartberger, Michael D, Correll, Tiffany L, Chow, David, Wong, Simon, Luo, Jian, Lin, Daniel C.-H, Medina, Julio C

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Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist von Brown, Sean P, Dransfield, Paul J, Vimolratana, Marc, Jiao, XianYun, Zhu, Liusheng, Pattaropong, Vatee, Sun, Ying, Liu, Jinqian, Luo, Jian, Zhang, Jane, Wong, Simon, Zhuang, Run, Guo, Qi, Li, Frank, Medina, Julio C, Swaminath, Gayathri, Lin, Daniel C.-H, Houze, Jonathan B

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Optimization of GPR40 Agonists for Type 2 Diabetes von Liu, Jiwen (Jim), Wang, Yingcai, Ma, Zhihua, Schmitt, Mike, Zhu, Liusheng, Brown, Sean P, Dransfield, Paul J, Sun, Ying, Sharma, Rajiv, Guo, Qi, Zhuang, Run, Zhang, Jane, Luo, Jian, Tonn, George R, Wong, Simon, Swaminath, Gayathri, Medina, Julio C, Lin, Daniel C.-H, Houze, Jonathan B

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Highly Regioselective Diels−Alder Reactions toward Oroidin Alkaloids:  Use of a Tosylvinyl Moiety as a Nitrogen Masking Group with Adjustable Electronics von Dransfield, Paul J, Wang, Shaohui, Dilley, Anja, Romo, Daniel

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A unified synthetic strategy toward oroidin-derived alkaloids premised on a biosynthetic proposal von Dransfield, Paul J., Dilley, Anja S., Wang, Shaohui, Romo, Daniel

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Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394 von Dransfield, Paul J, Pattaropong, Vatee, Lai, Sujen, Fu, Zice, Kohn, Todd J, Du, Xiaohui, Cheng, Alan, Xiong, Yumei, Komorowski, Renee, Jin, Lixia, Conn, Marion, Tien, Eric, DeWolf, Walter E, Hinklin, Ronald J, Aicher, Thomas D, Kraser, Christopher F, Boyd, Steven A, Voegtli, Walter C, Condroski, Kevin R, Veniant-Ellison, Murielle, Medina, Julio C, Houze, Jonathan, Coward, Peter

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Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists von Du, Xiaohui, Dransfield, Paul J, Lin, Daniel C.-H, Wong, Simon, Wang, Yingcai, Wang, Zhongyu, Kohn, Todd, Yu, Ming, Brown, Sean P, Vimolratana, Marc, Zhu, Liusheng, Li, An-Rong, Su, Yongli, Jiao, Xianyun, Liu, Jiwen (Jim), Swaminath, Gayathri, Tran, Thanhvien, Luo, Jian, Zhuang, Run, Zhang, Jane, Guo, Qi, Li, Frank, Connors, Richard, Medina, Julio C, Houze, Jonathan B

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Identification of 2‑Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay von Parker, Mackenzie J., Lee, Hyelee, Yao, Shihua, Irwin, Sean, Hwang, Sunil, Belanger, Kylie, de Mare, Sofia Woo, Surgenor, Richard, Yan, Lu, Gee, Patricia, Morla, Shravan, Puyang, Xiaoling, Hsiao, Peng, Zeng, Hao, Zhu, Ping, Korpal, Manav, Dransfield, Paul, Bolduc, David M., Larsen, Nicholas A.

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Divergent approach to imino sugar C-glycosides using imino glycals: application to the stereocontrolled synthesis of (+)-deoxoprosophylline von Dransfield, Paul J, Gore, Paul M, Shipman, Michael, Slawin, Alexandra M Z

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Preparation and reactivity of imino glycals: stereocontrolled, divergent approach to imino sugars von Dransfield, Paul J, Gore, Paul M, Prokes, Ivan, Shipman, Michael, Slawin, Alexandra M Z

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Highly Regioselective Diels−Alder Reactions toward Oroidin Alkaloids:  Use of a Tosylvinyl Moiety as a Nitrogen Masking Group with Adjustable Electronics von Dransfield, Paul J, Wang, Shaohui, Dilley, Anja, Romo, Daniel

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Cardiovascular response to small-molecule APJ activation von Ason, Brandon, Chen, Yinhong, Guo, Qi, Hoagland, Kimberly M., Chui, Ray W., Fielden, Mark, Sutherland, Weston, Chen, Rhonda, Zhang, Ying, Mihardja, Shirley, Ma, Xiaochuan, Li, Xun, Sun, Yaping, Liu, Dongming, Nguyen, Khanh, Wang, Jinghong, Li, Ning, Rajamani, Sridharan, Qu, Yusheng, Gao, BaoXi, Boden, Andrea, Chintalgattu, Vishnu, Turk, Jim R., Chan, Joyce, Hu, Liaoyuan A., Dransfield, Paul, Houze, Jonathan, Wong, Jingman, Ma, Ji, Pattaropong, Vatee, Veniant, Murielle M., Vargas, Hugo M., Swaminath, Gayathri, Khakoo, Aarif Y.

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Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates von Brown, Sean P., Dransfield, Paul, Vimolratana, Marc, Zhu, Liusheng, Luo, Jian, Zhang, Jane, Jiao, XianYun, Pattaropong, Vatee, Wong, Simon, Zhuang, Run, Swaminath, Gayathri, Houze, Jonathan B., Lin, Daniel C.-H.

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5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties von Kohn, Todd J, Du, Xiaohui, Lai, SuJen, Xiong, YuMei, Komorowski, Renee, Veniant, Murielle, Fu, Zice, Jiao, Xianyun, Pattaropong, Vatee, Chow, David, Cardozo, Mario, Jin, Lixia, Conn, Marion, DeWolf, Walter E, Kraser, Christopher F, Hinklin, Ronald J, Boys, Mark L, Medina, Julio C, Houze, Jonathan, Dransfield, Paul, Coward, Peter

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Stereocontrolled synthesis of polyhydroxylated hexahydro-1H-cyclopent[c]isoxazoles by intramolecular oxime olefin cycloadditions: an approach to aminocyclopentitols von Dransfield, Paul J., Moutel, Stéphane, Shipman, Michael, Sik, Vladimir

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C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators von Du, Xiaohui, Hinklin, Ronald J, Xiong, Yumei, Dransfield, Paul, Park, Jaehyeon, Kohn, Todd J, Pattaropong, Vatee, Lai, SuJen, Fu, Zice, Jiao, Xianyun, Chow, David, Jin, Lixia, Davda, Jasmine, Veniant, Murielle M, Anderson, Deborah A, Baer, Brian R, Bencsik, Josef R, Boyd, Steven A, Chicarelli, Mark Joseph, Mohr, Peter J, Wang, Bin, Condroski, Kevin R, DeWolf, Walter E, Conn, Marion, Tran, Thanhvien, Yang, Jerry, Aicher, Thomas D, Medina, Julio C, Coward, Peter, Houze, Jonathan B

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Chemistry of Imino Glycals: Preparation and Application to the Synthesis of (+)-Fagomine von Désiré, Jérôme, Dransfield, Paul J., Gore, Paul M., Shipman, Michael

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