Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory von Mews, Philipp, Donahue, Greg, Drake, Adam M., Luczak, Vincent, Abel, Ted, Berger, Shelley L.

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Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis von Novershtern, Noa, Subramanian, Aravind, Lawton, Lee N., Mak, Raymond H., Haining, W. Nicholas, McConkey, Marie E., Habib, Naomi, Yosef, Nir, Chang, Cindy Y., Shay, Tal, Frampton, Garrett M., Drake, Adam C.B., Leskov, Ilya, Nilsson, Bjorn, Preffer, Fred, Dombkowski, David, Evans, John W., Liefeld, Ted, Smutko, John S., Chen, Jianzhu, Friedman, Nir, Young, Richard A., Golub, Todd R., Regev, Aviv, Ebert, Benjamin L.

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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade von Pauken, Kristen E., Sammons, Morgan A., Odorizzi, Pamela M., Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M., Chen, Zeyu, Sen, Debattama R., Kurachi, Makoto, Barnitz, R. Anthony, Bartman, Caroline, Bengsch, Bertram, Huang, Alexander C., Schenkel, Jason M., Vahedi, Golnaz, Haining, W. Nicholas, Berger, Shelley L., Wherry, E. John

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Autophagy mediates degradation of nuclear lamina von Dou, Zhixun, Xu, Caiyue, Donahue, Greg, Shimi, Takeshi, Pan, Ji-An, Zhu, Jiajun, Ivanov, Andrejs, Capell, Brian C., Drake, Adam M., Shah, Parisha P., Catanzaro, Joseph M., Daniel Ricketts, M., Lamark, Trond, Adam, Stephen A., Marmorstein, Ronen, Zong, Wei-Xing, Johansen, Terje, Goldman, Robert D., Adams, Peter D., Berger, Shelley L.

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Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA von Wan, Nathan, Weinberg, David, Liu, Tzu-Yu, Niehaus, Katherine, Ariazi, Eric A, Delubac, Daniel, Kannan, Ajay, White, Brandon, Bailey, Mitch, Bertin, Marvin, Boley, Nathan, Bowen, Derek, Cregg, James, Drake, Adam M, Ennis, Riley, Fransen, Signe, Gafni, Erik, Hansen, Loren, Liu, Yaping, Otte, Gabriel L, Pecson, Jennifer, Rice, Brandon, Sanderson, Gabriel E, Sharma, Aarushi, St John, John, Tang, Catherina, Tzou, Abraham, Young, Leilani, Putcha, Girish, Haque, Imran S

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TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity von Sammons, Morgan A, Zhu, Jiajun, Drake, Adam M, Berger, Shelley L

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MLL1 is essential for the senescence-associated secretory phenotype von Capell, Brian C, Drake, Adam M, Zhu, Jiajun, Shah, Parisha P, Dou, Zhixun, Dorsey, Jean, Simola, Daniel F, Donahue, Greg, Sammons, Morgan, Rai, Taranjit Singh, Natale, Christopher, Ridky, Todd W, Adams, Peter D, Berger, Shelley L

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Graphene Multilayers as Gates for Multi-Week Sequential Release of Proteins from Surfaces von Hong, Jinkee, Shah, Nisarg J, Drake, Adam C, DeMuth, Peter C, Lee, Jong Bum, Chen, Jianzhu, Hammond, Paula T

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Engineering humanized mice for improved hematopoietic reconstitution von Drake, Adam C, Chen, Qingfeng, Chen, Jianzhu

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Induction and Therapeutic Targeting of Human NPM1c + Myeloid Leukemia in the Presence of Autologous Immune System in Mice von Kaur, Mandeep, Drake, Adam C, Hu, Guangan, Rudnick, Stephen, Chen, Qingfeng, Phennicie, Ryan, Attar, Ricardo, Nemeth, Jeffrey, Gaudet, Francois, Chen, Jianzhu

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Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rγ-/- (NSG) mice von Drake, Adam C, Khoury, Maroun, Leskov, Ilya, Iliopoulou, Bettina P, Fragoso, Maria, Lodish, Harvey, Chen, Jianzhu

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Sensitizing Protective Tumor Microenvironments to Antibody-Mediated Therapy von Pallasch, Christian P., Leskov, Ilya, Braun, Christian J., Vorholt, Daniela, Drake, Adam, Soto-Feliciano, Yadira M., Bent, Eric H., Schwamb, Janine, Iliopoulou, Bettina, Kutsch, Nadine, van Rooijen, Nico, Frenzel, Lukas P., Wendtner, Clemens M., Heukamp, Lukas, Kreuzer, Karl Anton, Hallek, Michael, Chen, Jianzhu, Hemann, Michael T.

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Of mice and men: what rodent models don't tell us von Drake, Adam C

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Interleukins 7 and 15 Maintain Human T Cell Proliferative Capacity through STAT5 Signaling von Drake, Adam, Kaur, Mandeep, Iliopoulou, Bettina P, Phennicie, Ryan, Hanson, Amanda, Chen, Jianzhu

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Identification of DNA-PK in the arthropods: Evidence for the ancient ancestry of vertebrate non-homologous end-joining von Doré, Andrew S, Drake, Adam C.B, Brewerton, Suzanne C, Blundell, Tom L

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Oral Administration of FT-4202, an Allosteric Activator of Pyruvate Kinase-R, Has Potent Anti-Sickling Effects in a Sickle Cell Anemia (SCA) Mouse Model, Resulting in Improved RBC... von Shrestha, Archana, Chi, Mengna, Wagner, Kimberly, Drake, Adam, Fulzele, Keertik, Guichard, Sylvie, Malik, Punam

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Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease von Schroeder, Patricia, Fulzele, Keertik, Forsyth, Sanjeev, Ribadeneira, Maria D, Guichard, Sylvie, Wilker, Erik, Marshall, C Gary, Drake, Adam, Fessler, Rose, Konstantinidis, Diamantis G, Seu, Katie G, Kalfa, Theodosia A

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A Phase 1, First-in-Human, Dose Escalation and Dose-Expansion Study of a BCMAxCD38xCD3 Targeting Trispecific Antibody ISB 2001 in Subjects with Relapsed/Refractory Multiple Myeloma von Sia, Hanlon, Menon, Vinu, Garton, Andrew, Wolff, Eileen, Shah, Tejas, Charpentier, Colleen, Duchesne, Dominique, Pihlgren, Maria, Koch-Olsen, Jeppe, Drake, Adam, Perro, Mario, Zhukovsky, Eugene, Pacaud, Lida, Konto, Cyril

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Preclinical characterization of ISB 1342, a CD38 × CD3 T-cell engager for relapsed/refractory multiple myeloma von Pouleau, Blandine, Estoppey, Carole, Suere, Perrine, Nallet, Emilie, Laurendon, Amélie, Monney, Thierry, Pais Ferreira, Daniela, Drake, Adam, Carretero-Iglesia, Laura, Macoin, Julie, Berret, Jérémy, Pihlgren, Maria, Doucey, Marie-Agnès, Gudi, Girish S., Menon, Vinu, Udupa, Venkatesha, Maiti, Abhishek, Borthakur, Gautam, Srivastava, Ankita, Blein, Stanislas, Mbow, M. Lamine, Matthes, Thomas, Kaya, Zeynep, Edwards, Claire M., Edwards, James R., Menoret, Emmanuelle, Kervoëlen, Charlotte, Pellat-Deceunynck, Catherine, Moreau, Philippe, Zhukovsky, Eugene, Perro, Mario, Chimen, Myriam

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Integrated Preclinical Data Analysis of ISB 2001 Enables Optimal Starting Dose Selection for a First-in-Class Trispecific T Cell Engager Phase1 Study in Multiple Myeloma von Drake, Adam, Pihlgren, Maria, Menon, Vinu, Pais, Daniela, Carretero-Iglesia, Laura, Berret, Jeremy, Hall, Olivia, Macoin, Julie, Gruber, Isabelle, Stainnack, Elodie, Estoppey, Carole, Dreyfus, Cyrille, Gudi, Girish, Matsuura, Tomomi, van der Graft, Piet H, Dyson, Michael, Konto, Cyril, Pacaud, Lida, Srivastava, Ankita, Zhukovsky, Eugene, Perro, Mario

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