Abstract CT007: PETRA: First in class, first in human trial of the next generation PARP1-selective inhibitor AZD5305 in patients (pts) with BRCA1/2, PALB2 or RAD51C/D mutations von Yap, Timothy A., Im, Seock-Ah, Schram, Alison M., Sharp, Adam, Balmana, Judith, Baird, Richard D., Brown, Jessica S., Schwaederle, Maria, Pilling, Elizabeth A., Moorthy, Ganesh, Linardopoulos, Spiros, Dowson, Adam, Pound, Carol, Lukacs, Edit, Cosulich, Sabina, Luen, Stephen J.

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Abstract CT269: A highly sensitive and specific PARylation assay confirms significant and durable target engagement by AZD5305 in patients von Lombardi, Benedetta, Marco-Casanova, Paola, Karapetsas, Athanasios, Hornett, Mya, Lukacs, Edit, Sugibayashi, Ko, Cosulich, Sabina, Dowson, Adam, Moorthy, Ganesh, Brown, Jessica, Yap, Timothy A., Schram, Alison M., Balmana, Judith, Luen, Stephen J., Im, Seock-Ah, Sharp, Adam, Baird, Richard, Harrington, Elizabeth A., Linardopoulos, Spiros

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Abstract CT007: PETRA: First in class, first in human trial of the next generation PARP1-selective inhibitor AZD5305 in patients (pts) with BRCA1/2, PALB2 or RAD51C/D mutations von Yap, Timothy A, Im, Seock-Ah, Schram, Alison M, Sharp, Adam, Balmana, Judith, Baird, Richard D, Brown, Jessica S, Schwaederle, Maria, Pilling, Elizabeth A, Moorthy, Ganesh, Linardopoulos, Spiros, Dowson, Adam, Pound, Carol, Lukacs, Edit, Cosulich, Sabina, Luen, Stephen J

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Abstract CT269: A highly sensitive and specific PARylation assay confirms significant and durable target engagement by AZD5305 in patients von Lombardi, Benedetta, Marco-Casanova, Paola, Karapetsas, Athanasios, Hornett, Mya, Lukacs, Edit, Sugibayashi, Ko, Cosulich, Sabina, Dowson, Adam, Moorthy, Ganesh, Brown, Jessica, Yap, Timothy A, Schram, Alison M, Balmana, Judith, Luen, Stephen J, Im, Seock-Ah, Sharp, Adam, Baird, Richard, Harrington, Elizabeth A, Linardopoulos, Spiros

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DOSING REGIMENT OF AZD5305 von COSULICH, Sabina Chiara, MOORTHY, Ganesh, BROWN, Jessica S, FRANCIS, Richard Edward, LUKACS, Edit Eva, DOWSON, Adam, WILKS, Chris

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DOSING REGIMEN von COSULICH, Sabina Chiara, MOORTHY, Ganesh, BROWN, Jessica S, FRANCIS, Richard Edward, LUKACS, Edit Eva, DOWSON, Adam, WILKS, Chris

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Domestic UK retrofit challenge: Barriers, incentives and current performance leading into the Green Deal von Dowson, Mark, Poole, Adam, Harrison, David, Susman, Gideon

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There is no market for new antibiotics: this allows an open approach to research and development von Klug, Dana M, Idiris, Fahima I M, Blaskovich, Mark A T, von Delft, Frank, Dowson, Christopher G, Kirchhelle, Claas, Roberts, Adam P, Singer, Andrew C, Todd, Matthew H

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Expanded Multilocus Sequence Typing for Burkholderia Species von SPILKER, Theodore, BALDWIN, Adam, BUMFORD, Amy, DOWSON, Chris G, MAHENTHIRALINGAM, Eshwar, LIPUMA, John J

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Key Role for Efflux in the Preservative Susceptibility and Adaptive Resistance of Burkholderia cepacia Complex Bacteria von RUSHTON, Laura, SASS, Andrea, BALDWIN, Adam, DOWSON, Christopher G, DONOGHUE, Denise, MAHENTHIRALINGAM, Eshwar

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Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp. nov. and Burkholderia lata sp. nov von Vanlaere, Elke, Baldwin, Adam, Gevers, Dirk, Henry, Deborah, De Brandt, Evie, LiPuma, John J, Mahenthiralingam, Eshwar, Speert, David P, Dowson, Chris, Vandamme, Peter

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Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder von Aron, Adam R, Dowson, Jonathon H, Sahakian, Barbara J, Robbins, Trevor W

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Association Between Response Inhibition and Working Memory in Adult ADHD: A Link to Right Frontal Cortex Pathology? von Clark, Luke, Blackwell, Andrew D, Aron, Adam R, Turner, Danielle C, Dowson, Jonathan, Robbins, Trevor W, Sahakian, Barbara J

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Multilocus Sequence Typing Scheme That Provides Both Species and Strain Differentiation for the Burkholderia cepacia Complex von Baldwin, Adam, Mahenthiralingam, Eshwar, Thickett, Kathleen M, Honeybourne, David, Maiden, Martin C. J, Govan, John R, Speert, David P, LiPuma, John J, Vandamme, Peter, Dowson, Chris G

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Biocide susceptibility of the Burkholderia cepacia complex von Rose, Helen, Baldwin, Adam, Dowson, Christopher G., Mahenthiralingam, Eshwar

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Multilocus sequence typing of Cronobacter sakazakii and Cronobacter malonaticus reveals stable clonal structures with clinical significance which do not correlate with biotypes von Baldwin, Adam, Loughlin, Michael, Caubilla-Barron, Juncal, Kucerova, Eva, Manning, Georgina, Dowson, Christopher, Forsythe, Stephen

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Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing von Lysenko, Elena S, Clarke, Thomas B, Shchepetov, Mikhail, Ratner, Adam J, Roper, David I, Dowson, Christopher G, Weiser, Jeffrey N

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Multilocus Sequence Typing Identifies Evidence for Recombination and Two Distinct Lineages of Corynebacterium diphtheriae von Bolt, Frances, Cassiday, Pamela, Tondella, Maria Lucia, DeZoysa, Aruni, Efstratiou, Androulla, Sing, Andreas, Zasada, Aleksandra, Bernard, Kathryn, Guiso, Nicole, Badell, Edgar, Rosso, Marie-Laure, Baldwin, Adam, Dowson, Christopher

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A protein blueprint of the diatom CO2-fixing organelle von Nam, Onyou, Musiał, Sabina, Demulder, Manon, McKenzie, Caroline, Dowle, Adam, Dowson, Matthew, Barrett, James, Blaza, James N., Engel, Benjamin D., Mackinder, Luke C.M.

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Cognitive enhancing effects of modafinil in healthy volunteers von TURNER, Danielle C, ROBBINS, Trevor W, CLARK, Luke, ARON, Adam R, DOWSON, Jonathan, SAHAKIAN, Barbara J

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