PTEN function: how normal cells control it and tumour cells lose it von Leslie, Nick R, Downes, C Peter

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Redox regulation of PI 3-kinase signalling via inactivation of PTEN von Leslie, Nick R., Bennett, Deborah, Lindsay, Yvonne E., Stewart, Hazel, Gray, Alex, Downes, C.Peter

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The TSC1-2 Tumor Suppressor Controls Insulin-PI3K Signaling via Regulation of IRS Proteins von Harrington, Laura S., Findlay, Greg M., Gray, Alex, Tolkacheva, Tatiana, Wigfield, Simon, Rebholz, Heike, Barnett, Jill, Leslie, Nick R., Cheng, Susan, Shepherd, Peter R., Gout, Ivan, Downes, C. Peter, Lamb, Richard F.

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Probing phosphoinositide functions in signaling and membrane trafficking von Downes, C. Peter, Gray, Alex, Lucocq, John M.

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PTEN: The down side of PI 3-kinase signalling von Leslie, Nick R., Downes, C.Peter

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A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation von Clayton, Elizabeth, Bardi, Giuseppe, Bell, Sarah E., Chantry, David, Downes, C. Peter, Gray, Alexander, Humphries, Lisa A., Rawlings, David, Reynolds, Helen, Vigorito, Elena, Turner, Martin

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Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN von Patel, Lisa, Pass, Ian, Coxon, Phil, Downes, C.Peter, Smith, Stephen A., Macphee, Colin H.

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Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities von Dowler, S, Currie, R A, Campbell, D G, Deak, M, Kular, G, Downes, C P, Alessi, D R

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2 von Balendran, Anudharan, Casamayor, Antonio, Deak, Maria, Paterson, Andrew, Gaffney, Piers, Currie, Richard, Downes, C.Peter, Alessi, Dario R.

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα von Alessi, Dario R., James, Stephen R., Downes, C.Peter, Holmes, Andrew B., Gaffney, Piers R.J., Reese, Colin B., Cohen, Philip

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Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates von Komander, David, Fairservice, Alison, Deak, Maria, Kular, Gursant S, Prescott, Alan R, Peter Downes, C, Safrany, Stephen T, Alessi, Dario R, van Aalten, Daan MF

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The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif von Walker, Steven M, Leslie, Nick R, Perera, Nevin M, Batty, Ian H, Downes, C Peter

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dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1 von Radimerski, Thomas, Montagne, Jacques, Rintelen, Felix, Stocker, Hugo, van der Kaay, Jeroen, Downes, C Peter, Hafen, Ernst, Thomas, George

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Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids von McConnachie, George, Pass, Ian, Walker, Steven M, Downes, C Peter

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Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts von Gray, Alexander, Olsson, Henric, Batty, Ian H, Priganica, Larisa, Peter Downes, C

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The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidy... von Gray, A, Van Der Kaay, J, Downes, C P

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The role of PI 3-kinase in insulin action von Alessi, D.R., Downes, C.P.

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Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo von SPRUCE, Barbara A, CAMPBELL, Lorna A, MCLEAN, Doris, LESLIE, Nick R, SAFRANY, Stephen T, FERGUSON, Michelle J, PETERS, John A, PRESCOTT, Alan R, BOX, Gary, HAYES, Angela, NUTLEY, Bernard, RAYNAUD, Florence, MCTAVISH, Niall, DOWNES, C. Peter, LAMBERT, Jeremy J, THOMPSON, Alastair M, ECCLES, Suzanne, COOPER, Michelle A, APPLEYARD, M. Virginia L, O'NEILL, Mary, HOWIE, Jacqueline, SAMSON, Jayne, WATT, Stephen, MURRAY, Karen

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Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1 von Currie, R A, Walker, K S, Gray, A, Deak, M, Casamayor, A, Downes, C P, Cohen, P, Alessi, D R, Lucocq, J

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The Role of Dynamin and Its Binding Partners in Coated Pit Invagination and Scission von Hill, Elaine, van der Kaay, Jeroen, Downes, C. Peter, Smythe, Elizabeth

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