A Novel Scalarized Scaffold Hopping Algorithm with Graph-Based Variational Autoencoder for Discovery of JAK1 Inhibitors von Yu, Yang, Xu, Tingyang, Li, Jiawen, Qiu, Yaping, Rong, Yu, Gong, Zhen, Cheng, Xuemin, Dong, Liming, Liu, Wei, Li, Jin, Dou, Dengfeng, Huang, Junzhou

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Inhibition of noroviruses by piperazine derivatives von Dou, Dengfeng, He, Guijia, Mandadapu, Sivakoteswara Rao, Aravapalli, Sridhar, Kim, Yunjeong, Chang, Kyeong-Ok, Groutas, William C.

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Amino Acid-Derived 1,2-Benzisothiazolinone Derivatives as Novel Small-Molecule Antifungal Inhibitors: Identification of Potential Genetic Targets von ALEX, Deepu, GAY-ANDRIEU, Francoise, MAY, Jared, THAMPI, Linta, DENGFENG DOU, MOONEY, Aileen, GROUTAS, William, CALDERONE, Richard

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Antifungal activity of a series of 1,2-benzisothiazol-3(2 H)-one derivatives von Dou, Dengfeng, Alex, Deepu, Du, Bingfan, Tiew, Kok-Chuan, Aravapalli, Sridhar, Mandadapu, Sivakoteswara Rao, Calderone, Richard, Groutas, William C.

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Cyclosulfamide-based derivatives as inhibitors of noroviruses von Dou, Dengfeng, Mandadapu, Sivakoteswara R., Alliston, Kevin R., Kim, Yunjeong, Chang, Kyeong-Ok, Groutas, William C.

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Design and synthesis of inhibitors of noroviruses by scaffold hopping von Dou, Dengfeng, Mandadapu, Sivakoteswara Rao, Alliston, Kevin R., Kim, Yunjeong, Chang, Kyeong-Ok, Groutas, William C.

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Potent inhibition of Norwalk virus by cyclic sulfamide derivatives von Dou, Dengfeng, Tiew, Kok-Chuan, He, Guijia, Mandadapu, Sivakoteswara Rao, Aravapalli, Sridhar, Alliston, Kevin R., Kim, Yunjeong, Chang, Kyeong-Ok, Groutas, William C.

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Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives von Tiew, Kok-Chuan, Dou, Dengfeng, Teramoto, Tadahisa, Lai, Huiguo, Alliston, Kevin R., Lushington, Gerald H., Padmanabhan, R., Groutas, William C.

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Dual function inhibitors of relevance to chronic obstructive pulmonary disease von Dou, Dengfeng, He, Guijia, Alliston, Kevin R., Groutas, William C.

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Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold von He, Guijia, Dou, Dengfeng, Wei, Liuqing, Alliston, Kevin R., Groutas, William C.

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Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3 von Dou, Dengfeng, He, Guijia, Li, Yi, Lai, Zhong, Wei, Liuqing, Alliston, Kevin R., Lushington, Gerald H., Eichhorn, David M., Groutas, William C.

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Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S′ subsite binding von Li, Yi, Dou, Dengfeng, He, Guijia, Lushington, Gerald H., Groutas, William C.

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X-ray Snapshot of the Mechanism of Inactivation of Human Neutrophil Elastase by 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives von Huang, Weijun, Yamamoto, Yasufumi, Li, Yi, Dou, Dengfeng, Alliston, Kevin R, Hanzlik, Robert P, Williams, Todd D, Groutas, William C

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Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase von Dou, Dengfeng, He, Guijia, Kuang, Rongze, Fu, Qingfong, Venkataraman, Radhika, Groutas, William C.

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Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides von Li, Yi, Yang, Qingliang, Dou, Dengfeng, Alliston, Kevin R., Groutas, William C.

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Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA von Chen, Qiuxia, Li, You, Lin, Chunrong, Chen, Liu, Luo, Hao, Xia, Shuai, Liu, Chuan, Cheng, Xuemin, Liu, Chengzhong, Li, Jin, Dou, Dengfeng

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Optimization of PROTAC Ternary Complex Using DNA Encoded Library Approach von Chen, Qiuxia, Liu, Chuan, Wang, Wei, Meng, Xiaoyun, Cheng, Xuemin, Li, Xianyang, Cai, Longying, Luo, Linfu, He, Xu, Qu, Huan, Luo, Jing, Wei, Hong, Gao, Sen, Liu, Guansai, Wan, Jinqiao, Israel, David I., Li, Jin, Dou, Dengfeng

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Re-Evaluating PIN1 as a Therapeutic Target in Oncology Using Neutral Inhibitors and PROTACs von Liu, Chuan, Chen, Zhonghui, Chen, Tao, Song, Hongmei, Shen, Jianbo, Yuan, Xiaoxi, Xia, Shuai, Liu, Qian, Chen, Qiuxia, Tian, Qiang, Meng, Xiaoyun, Han, Zhu, Dong, Xiaofei, Yang, Yu, Cai, Longying, Cheng, Xuemin, Jia, Yangyang, Liu, Guansai, Li, Jin, Ge, Junyou, Dou, Dengfeng

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The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening von Hartman, George, Humphries, Paul, Hughes, Robert, Ho, Andrew, Montgomery, Rusty, Deshpande, Aditi, Mahanta, Maitriyee, Tronnes, Sarah, Cowdin, Samantha, He, Xu, Liu, Fangchao, Zhang, Lifang, Liu, Chuan, Dou, Dengfeng, Li, Jin, Spasic, Aleksander, Coll, Rebecca, Marleaux, Michael, Hochheiser, Inga V., Geyer, Matthias, Rubin, Paul, Fortney, Kristen, Wilhelmsen, Kevin

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Exploring the Lower Limit of Individual DNA-Encoded Library Molecules in Selection von Chen, Qiuxia, Cheng, Xuemin, Zhang, Lifang, Li, Xianyang, Chen, Purui, Liu, Jian, Zhang, Lanjun, Wei, Hong, Li, Zhonghan, Dou, Dengfeng

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