Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design von Dorywalska, Magdalena, Dushin, Russell, Moine, Ludivine, Farias, Santiago E, Zhou, Dahui, Navaratnam, Thayalan, Lui, Victor, Hasa-Moreno, Adela, Casas, Meritxell Galindo, Tran, Thomas-Toan, Delaria, Kathy, Liu, Shu-Hui, Foletti, Davide, O'Donnell, Christopher J, Pons, Jaume, Shelton, David L, Rajpal, Arvind, Strop, Pavel

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Irreversible chemical steps control intersubunit dynamics during translation von Marshall, R. Andrew, Dorywalska, Magdalena, Puglisi, Joseph D

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Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy von Dorywalska, Magdalena, Strop, Pavel, Melton-Witt, Jody A, Hasa-Moreno, Adela, Farias, Santiago E, Galindo Casas, Meritxell, Delaria, Kathy, Lui, Victor, Poulsen, Kris, Sutton, Janette, Bolton, Gary, Zhou, Dahui, Moine, Ludivine, Dushin, Russell, Tran, Thomas-Toan, Liu, Shu-Hui, Rickert, Mathias, Foletti, Davide, Shelton, David L, Pons, Jaume, Rajpal, Arvind

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Translation at the single-molecule level von Marshall, R Andrew, Aitken, Colin Echeverría, Dorywalska, Magdalena, Puglisi, Joseph D

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Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates von Costa, Maria José, Kudaravalli, Jyothirmayee, Ma, Jing-Tyan, Ho, Wei-Hsien, Delaria, Kathy, Holz, Charles, Stauffer, Angela, Chunyk, Allison Given, Zong, Qing, Blasi, Eileen, Buetow, Bernard, Tran, Thomas-Toan, Lindquist, Kevin, Dorywalska, Magdalena, Rajpal, Arvind, Shelton, David L., Strop, Pavel, Liu, Shu-Hui

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Abstract 2640: RN927C, a potent site-specific Trop-2 antibody-drug-conjugate (ADC) for treatment of solid tumors von Liu, Shu-Hui, Strop, Pavel, Tran, Thomas-Toan, Dorywalska, Magdalena, Delaria, Katherine, Ho, Wei-Hsien, Dushin, Russell, Pons, Jaume, Rajpal, Arvind, Shelton, Dave

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Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading von Strop, Pavel, Delaria, Kathy, Foletti, Davide, Witt, Jody Melton, Hasa-Moreno, Adela, Poulsen, Kris, Casas, Meritxell Galindo, Dorywalska, Magdalena, Farias, Santiago, Pios, Ariel, Lui, Victor, Dushin, Russell, Zhou, Dahui, Navaratnam, Thayalan, Tran, Thomas-Toan, Sutton, Janette, Lindquist, Kevin C, Han, Bora, Liu, Shu-Hui, Shelton, David L, Pons, Jaume, Rajpal, Arvind

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RN927C, a Site-Specific Trop-2 Antibody-Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models von Strop, Pavel, Tran, Thomas-Toan, Dorywalska, Magdalena, Delaria, Kathy, Dushin, Russell, Wong, Oi Kwan, Ho, Wei-Hsien, Zhou, Dahui, Wu, Aidong, Kraynov, Eugenia, Aschenbrenner, Laura, Han, Bora, O'Donnell, Christopher J, Pons, Jaume, Rajpal, Arvind, Shelton, Dave L, Liu, Shu-Hui

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Effect of Attachment Site on Stability of Cleavable Antibody Drug Conjugates von Dorywalska, Magdalena, Strop, Pavel, Melton-Witt, Jody A, Hasa-Moreno, Adela, Farias, Santiago E, Galindo Casas, Meritxell, Delaria, Kathy, Lui, Victor, Poulsen, Kris, Loo, Carole, Krimm, Stellanie, Bolton, Gary, Moine, Ludivine, Dushin, Russell, Tran, Thomas-Toan, Liu, Shu-Hui, Rickert, Mathias, Foletti, Davide, Shelton, David L, Pons, Jaume, Rajpal, Arvind

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Mass Spectrometric Characterization of Transglutaminase Based Site-Specific Antibody–Drug Conjugates von Farias, Santiago E, Strop, Pavel, Delaria, Kathy, Galindo Casas, Meritxell, Dorywalska, Magdalena, Shelton, David L, Pons, Jaume, Rajpal, Arvind

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An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity von Xu, Yuanming, Carrascosa, Lucia Campos, Yeung, Yik Andy, Chu, Matthew Ling-Hon, Yang, Wenjing, Djuretic, Ivana, Pappas, Danielle C, Zeytounian, John, Ge, Zhouhong, de Ruiter, Valeska, Starbeck-Miller, Gabriel R, Patterson, James, Rigas, Diamanda, Chen, Shih-Hsun, Kraynov, Eugenia, Boor, Patrick P, Noordam, Lisanne, Doukas, Michael, Tsao, Dave, Ijzermans, Jan N, Guo, Jie, Grünhagen, Dirk J, Erdmann, Joris, Verheij, Joanne, van Royen, Martin E, Doornebosch, Pascal G, Feldman, Renny, Park, Terrence, Mahmoudi, Salah, Dorywalska, Magdalena, Ni, Irene, Chin, Sherman M, Mistry, Tina, Mosyak, Lidia, Lin, Laura, Ching, Keith A, Lindquist, Kevin C, Ji, Changhua, Londono, Luz Marina, Kuang, Bing, Rickert, Robert, Kwekkeboom, Jaap, Sprengers, Dave, Huang, Tzu-Hsuan, Chaparro-Riggers, Javier

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Site-specific labeling of the ribosome for single-molecule spectroscopy von Dorywalska, Magdalena, Blanchard, Scott C., Gonzalez, Ruben L., Kim, Harold D., Chu, Steven, Puglisi, Joseph D.

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Characterization and hetereologous expression of cDNAs encoding two novel closely related Ca2+-binding proteins in Dictyostelium discoideum von Dorywalska, Magdalena, Coukell, Barrie, Dharamsi, Akil

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Peptide bond formation destabilizes Shine-Dalgarno interaction on the ribosome von Chu, Steven, Dorywalska, Magdalena, Lee, Tae-Hee, Uemura, Sotaro, Puglisi, Joseph D, Kim, Harold D

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1P557 Peptide bond formation induces the breakage of Shine-Dalgarno interaction on the ribosome(26. Single molecule biophysics,Poster Session,Abstract,Meeting Program of EABS & BSJ... von Uemura, Sotaro, Dorywalska, Magdalena, Lee, Tae-Hee, Kim, Harold, Puglisi, Joseph, Chu, Steven

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Refined crystallographic structure of Pseudomonas aeruginosa exotoxin A and its implications for the molecular mechanism of toxicity von Wedekind, J E, Trame, C B, Dorywalska, M, Koehl, P, Raschke, T M, McKee, M, FitzGerald, D, Collier, R J, McKay, D B

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Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates von Strop, Pavel, Liu, Shu-Hui, Dorywalska, Magdalena, Delaria, Kathy, Dushin, Russell G., Tran, Thomas-Toan, Ho, Wei-Hsien, Farias, Santiago, Casas, Meritxell Galindo, Abdiche, Yasmina, Zhou, Dahui, Chandrasekaran, Ramalakshmi, Samain, Caroline, Loo, Carole, Rossi, Andrea, Rickert, Mathias, Krimm, Stellanie, Wong, Teresa, Chin, Sherman Michael, Yu, Jessica, Dilley, Jeanette, Chaparro-Riggers, Javier, Filzen, Gary F., O’Donnell, Christopher J., Wang, Fang, Myers, Jeremy S., Pons, Jaume, Shelton, David L., Rajpal, Arvind

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Characterization and hetereologous expression of cDNAs encoding two novel closely related Ca 2+-binding proteins in Dictyostelium discoideum von Dorywalska, Magdalena, Coukell, Barrie, Dharamsi, Akil

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STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES von DUSHIN, Russell George, STROP, Pavel, DORYWALSKA, Magdalena Grazyna, MOINE, Ludivine

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Stability-modulating linkers for use with antibody drug conjugates von Dorywalska, Magdalena Grazyna, Strop, Pavel, Dushin, Russell George, Moine, Ludivine

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