Towards the sustainable discovery and development of new antibiotics von Miethke, Marcus, Pieroni, Marco, Weber, Tilmann, Brönstrup, Mark, Hammann, Peter, Halby, Ludovic, Arimondo, Paola B., Glaser, Philippe, Aigle, Bertrand, Bode, Helge B., Moreira, Rui, Li, Yanyan, Luzhetskyy, Andriy, Medema, Marnix H., Pernodet, Jean-Luc, Stadler, Marc, Tormo, José Rubén, Genilloud, Olga, Truman, Andrew W., Weissman, Kira J., Takano, Eriko, Sabatini, Stefano, Stegmann, Evi, Brötz-Oesterhelt, Heike, Wohlleben, Wolfgang, Seemann, Myriam, Empting, Martin, Hirsch, Anna K. H., Loretz, Brigitta, Lehr, Claus-Michael, Titz, Alexander, Herrmann, Jennifer, Jaeger, Timo, Alt, Silke, Hesterkamp, Thomas, Winterhalter, Mathias, Schiefer, Andrea, Pfarr, Kenneth, Hoerauf, Achim, Graz, Heather, Graz, Michael, Lindvall, Mika, Ramurthy, Savithri, Karlén, Anders, van Dongen, Maarten, Petkovic, Hrvoje, Keller, Andreas, Peyrane, Frédéric, Donadio, Stefano, Fraisse, Laurent, Piddock, Laura J. V., Gilbert, Ian H., Moser, Heinz E., Müller, Rolf

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Biosynthetic potential of uncultured Antarctic soil bacteria revealed through long-read metagenomic sequencing von Waschulin, Valentin, Borsetto, Chiara, James, Robert, Newsham, Kevin K., Donadio, Stefano, Corre, Christophe, Wellington, Elizabeth

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Discovering new bioactive molecules from microbial sources von Monciardini, Paolo, Iorio, Marianna, Maffioli, Sonia, Sosio, Margherita, Donadio, Stefano

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Antibiotic discovery in the twenty-first century: current trends and future perspectives von Donadio, Stefano, Maffioli, Sonia, Monciardini, Paolo, Sosio, Margherita, Jabes, Daniela

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Zn-dependent bifunctional proteases are responsible for leader peptide processing of class III lanthipeptides von Chen, Shaoming, Xu, Bing, Chen, Erquan, Wang, Jiaqi, Lua, Jingxia, Donadio, Stefano, Ge, Huiming, Wang, Huan

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Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature von Arnison, Paul G, Bibb, Mervyn J, Bierbaum, Gabriele, Bowers, Albert A, Bugni, Tim S, Bulaj, Grzegorz, Camarero, Julio A, Campopiano, Dominic J, Challis, Gregory L, Clardy, Jon, Cotter, Paul D, Craik, David J, Dawson, Michael, Dittmann, Elke, Donadio, Stefano, Dorrestein, Pieter C, Entian, Karl-Dieter, Fischbach, Michael A, Garavelli, John S, Göransson, Ulf, Gruber, Christian W, Haft, Daniel H, Hemscheidt, Thomas K, Hertweck, Christian, Hill, Colin, Horswill, Alexander R, Jaspars, Marcel, Kelly, Wendy L, Klinman, Judith P, Kuipers, Oscar P, Link, A. James, Liu, Wen, Marahiel, Mohamed A, Mitchell, Douglas A, Moll, Gert N, Moore, Bradley S, Müller, Rolf, Nair, Satish K, Nes, Ingolf F, Norris, Gillian E, Olivera, Baldomero M, Onaka, Hiroyasu, Patchett, Mark L, Piel, Joern, Reaney, Martin J. T, Rebuffat, Sylvie, Ross, R. Paul, Sahl, Hans-Georg, Schmidt, Eric W, Selsted, Michael E, Severinov, Konstantin, Shen, Ben, Sivonen, Kaarina, Smith, Leif, Stein, Torsten, Süssmuth, Roderich D, Tagg, John R, Tang, Gong-Li, Truman, Andrew W, Vederas, John C, Walsh, Christopher T, Walton, Jonathan D, Wenzel, Silke C, Willey, Joanne M, van der Donk, Wilfred A

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Understanding the Mechanism of Action of NAI-112, a Lanthipeptide with Potent Antinociceptive Activity von Tocchetti, Arianna, Iorio, Marianna, Hamid, Zeeshan, Armirotti, Andrea, Reggiani, Angelo, Donadio, Stefano

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Blocks in the pseudouridimycin pathway unlock hidden metabolites in the Streptomyces producer strain von Iorio, Marianna, Davatgarbenam, Sahar, Serina, Stefania, Criscenzo, Paolo, Zdouc, Mitja M., Simone, Matteo, Maffioli, Sonia I., Ebright, Richard H., Donadio, Stefano, Sosio, Margherita

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Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3) von Lin, Wei, Das, Kalyan, Degen, David, Mazumder, Abhishek, Duchi, Diego, Wang, Dongye, Ebright, Yon W., Ebright, Richard Y., Sineva, Elena, Gigliotti, Matthew, Srivastava, Aashish, Mandal, Sukhendu, Jiang, Yi, Liu, Yu, Yin, Ruiheng, Zhang, Zhening, Eng, Edward T., Thomas, Dennis, Donadio, Stefano, Zhang, Haibo, Zhang, Changsheng, Kapanidis, Achillefs N., Ebright, Richard H.

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A Two-Component regulatory system with opposite effects on glycopeptide antibiotic biosynthesis and resistance von Alduina, Rosa, Tocchetti, Arianna, Costa, Salvatore, Ferraro, Clelia, Cancemi, Patrizia, Sosio, Margherita, Donadio, Stefano

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Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments von Zhang, Meng, Kong, Liyuan, Gong, Rong, Iorio, Marianna, Donadio, Stefano, Deng, Zixin, Sosio, Margherita, Chen, Wenqing

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Discovery, properties, and biosynthesis of pseudouridimycin, an antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase von Maffioli, Sonia I., Sosio, Margherita, Ebright, Richard H., Donadio, Stefano

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Efficacy of the New Lantibiotic NAI-107 in Experimental Infections Induced by Multidrug-Resistant Gram-Positive Pathogens von JABES, Daniela, BRUNATI, Cristina, CANDIANI, Gianpaolo, RIVA, Simona, ROMANO, Gabriella, DONADIO, Stefano

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Reticulibacter mediterranei gen. nov., sp. nov., within the new family Reticulibacteraceae fam. nov., and Ktedonospora formicarum gen. nov., sp. nov., Ktedonobacter robiniae sp. no... von Yabe, Shuhei, Zheng, Yu, Wang, Chiung-mei, Sakai, Yasuteru, Abe, Keietsu, Yokota, Akira, Donadio, Stefano, Cavaletti, Linda, Monciardini, Paolo

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Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis von Ortega, Manuel A., Hao, Yue, Walker, Mark C., Donadio, Stefano, Sosio, Margherita, Nair, Satish K., van der Donk, Wilfred A.

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Two Flavoenzymes Catalyze the Post-Translational Generation of 5‑Chlorotryptophan and 2‑Aminovinyl-Cysteine during NAI-107 Biosynthesis von Ortega, Manuel A, Cogan, Dillon P, Mukherjee, Subha, Garg, Neha, Li, Bo, Thibodeaux, Gabrielle N, Maffioli, Sonia I, Donadio, Stefano, Sosio, Margherita, Escano, Jerome, Smith, Leif, Nair, Satish K, van der Donk, Wilfred A

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New target for inhibition of bacterial RNA polymerase: ‘switch region’ von Srivastava, Aashish, Talaue, Meliza, Liu, Shuang, Degen, David, Ebright, Richard Y, Sineva, Elena, Chakraborty, Anirban, Druzhinin, Sergey Y, Chatterjee, Sujoy, Mukhopadhyay, Jayanta, Ebright, Yon W, Zozula, Alex, Shen, Juan, Sengupta, Sonali, Niedfeldt, Rui Rong, Xin, Cai, Kaneko, Takushi, Irschik, Herbert, Jansen, Rolf, Donadio, Stefano, Connell, Nancy, Ebright, Richard H

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In Silico Prediction and Prioritization of Novel Selective Antimicrobial Drug Targets in Escherichia coli von Svanberg Frisinger, Frida, Jana, Bimal, Donadio, Stefano, Guardabassi, Luca

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GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides von Zhang, Yu, Degen, David, Ho, Mary X, Sineva, Elena, Ebright, Katherine Y, Ebright, Yon W, Mekler, Vladimir, Vahedian-Movahed, Hanif, Feng, Yu, Yin, Ruiheng, Tuske, Steve, Irschik, Herbert, Jansen, Rolf, Maffioli, Sonia, Donadio, Stefano, Arnold, Eddy, Ebright, Richard H

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Direct detection of stringent alarmones (pp)pGpp using malachite green von Schicketanz, Muriel, Petrová, Magdalena, Rejman, Dominik, Sosio, Margherita, Donadio, Stefano, Zhang, Yong Everett

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