Unprecedented Catalytic Three Component One-Pot Condensation Reaction:  An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones von Hu, Essa H, Sidler, Daniel R, Dolling, Ulf-H

Volltext

The Expedient Synthesis of 4,2‘-Difluoro-5‘-(7-trifluoromethyl- imidazo[1,2-a]pyrimidin-3-yl)biphenyl-2-carbonitrile, a GABA α2/3 Agonist von Cameron, Mark, Foster, Bruce S, Lynch, Joseph E, Shi, Yao-Jun, Dolling, Ulf-H

Volltext

A Practical Synthesis of a γ-Secretase Inhibitor von Scott, Jeremy P, Lieberman, David R, Beureux, Olivier M, Brands, Karel M. J, Davies, Antony J, Gibson, Andrew W, Hammond, Deborah C, McWilliams, Chris J, Stewart, Gavin W, Wilson, Robert D, Dolling, Ulf-H

Volltext

Practical Asymmetric Synthesis of a γ-Secretase Inhibitor Exploiting Substrate-Controlled Intramolecular Nitrile Oxide−Olefin Cycloaddition von Scott, Jeremy P, Oliver, Steven F, Brands, Karel M. J, Brewer, Sarah E, Davies, Antony J, Gibb, Andrew D, Hands, David, Keen, Stephen P, Sheen, Faye J, Reamer, Robert A, Wilson, Robert D, Dolling, Ulf-H

Volltext

A new general method for preparation of N-methoxy- N-methylamides. Application in direct conversion of an ester to a ketone von Williams, J.Michael, Jobson, Ronald B., Yasuda, Nobuyoshi, Marchesini, George, Dolling, Ulf-H., Grabowski, Edward J.J.

Volltext

Synthesis of a NO-Releasing Prodrug of Rofecoxib von Engelhardt, F. Conrad, Shi, Yao-Jun, Cowden, Cameron J, Conlon, David A, Pipik, Brenda, Zhou, George, McNamara, James M, Dolling, Ulf-H

Volltext

Development of a Phase Transfer Catalyzed Asymmetric Synthesis for an Estrogen Receptor Beta Selective Agonist von Scott, Jeremy P, Ashwood, Michael S, Brands, Karel M. J, Brewer, Sarah E, Cowden, Cameron J, Dolling, Ulf-H, Emerson, Khateeta M, Gibb, Andrew D, Goodyear, Adrian, Oliver, Steven F, Stewart, Gavin W, Wallace, Debra J

Volltext

Practical Synthesis of Aryl Triflates under Aqueous Conditions von Frantz, Doug E, Weaver, Damian G, Carey, James P, Kress, Michael H, Dolling, Ulf H

Volltext

An Improved Preparation of 3,5-Bis(trifluoromethyl)acetophenone and Safety Considerations in the Preparation of 3,5-Bis(trifluoromethyl)phenyl Grignard Reagent von Leazer, Johnnie L., Cvetovich, Raymond, Tsay, Fuh-Rong, Dolling, Ulf, Vickery, Thomas, Bachert, Donald

Volltext

Stereoselective Synthesis of a Potent Thrombin Inhibitor by a Novel P2−P3 Lactone Ring Opening von Nelson, Todd D, LeBlond, Carl R, Frantz, Doug E, Matty, Louis, Mitten, Jeffrey V, Weaver, Damian G, Moore, Jeffrey C, Kim, Jaehon M, Boyd, Russell, Kim, Pei-Yi, Gbewonyo, Kodzo, Brower, Mark, Sturr, Michael, McLaughlin, Kathleen, McMasters, Daniel R, Kress, Michael H, McNamara, James M, Dolling, Ulf H

Volltext

A Double Ring Closing Metathesis Reaction in the Rapid, Enantioselective Synthesis of NK-1 Receptor Antagonists von Wallace, Debra J, Goodman, Jonathan M, Kennedy, Derek J, Davies, Antony J, Cowden, Cameron J, Ashwood, Michael S, Cottrell, Ian F, Dolling, Ulf-H, Reider, Paul J

Volltext

Practical Synthesis of the New Carbapenem Antibiotic Ertapenem Sodium von Williams, J. Michael, Brands, Karel M. J, Skerlj, Renato T, Jobson, Ronald B, Marchesini, George, Conrad, Karen M, Pipik, Brenda, Savary, Kimberly A, Tsay, Fuh-Rong, Houghton, Peter G, Sidler, D. Richard, Dolling, Ulf-H, DiMichele, Lisa M, Novak, Thomas J

Volltext

Practical Asymmetric Synthesis of Aprepitant, a Potent Human NK-1 Receptor Antagonist, via a Stereoselective Lewis Acid-Catalyzed Trans Acetalization Reaction von Zhao, Matthew M, McNamara, James M, Ho, Guo-Jie, Emerson, Khateeta M, Song, Zhiguo J, Tschaen, David M, Brands, Karel M. J, Dolling, Ulf-H, Grabowski, Edward J. J, Reider, Paul J, Cottrell, Ian F, Ashwood, Michael S, Bishop, Brian C

Volltext

A Novel Crystallization-Induced Diastereomeric Transformation Based on a Reversible Carbon−Sulfur Bond Formation. Application to the Synthesis of a γ-Secretase Inhibitor von Davies, Antony J, Scott, Jeremy P, Bishop, Brian C, Brands, Karel M. J, Brewer, Sarah E, DaSilva, Jimmy O, Dormer, Peter G, Dolling, Ulf-H, Gibb, Andrew D, Hammond, Deborah C, Lieberman, David R, Palucki, Michael, Payack, Joseph F

Volltext

Asymmetric Synthesis of MK-0499 von Tschaen, David M, Abramson, Lee, Cai, Dongwei, Desmond, Richard, Dolling, Ulf-H, Frey, Lisa, Karady, Sandor, Shi, Yao-Jun, Verhoeven, Thomas R

Volltext

Development of a Scaleable Synthesis of a Partial Nicotinic Acid Receptor Agonist von Wilson, Robert D, Cleator, Ed, Ashwood, Michael S, Bio, Matthew M, Brands, Karel M. J, Davies, Antony J, Dolling, Ulf-H, Emerson, Khateeta M, Gibb, Andrew D, Hands, David, McKeown, Arlene E, Oliver, Steven F, Reamer, Robert A, Sheen, Faye J, Stewart, Gavin W, Zhou, George X

Volltext

Practical Asymmetric Synthesis of an Endothelin Receptor Antagonist von Song, Zhiguo J, Zhao, Mangzhu, Desmond, Richard, Devine, Paul, Tschaen, David M, Tillyer, Richard, Frey, Lisa, Heid, Richard, Xu, Feng, Foster, Bruce, Li, Jing, Reamer, Robert, Volante, Ralph, Dolling, Ulf H, Reider, Paul J, Okada, Shigemitsu, Kato, Yoshiaki, Mano, Eiichi

Volltext

Regioselective synthesis of N-substituted-4-substituted isothiazolidine-1,1-dioxides von Cleator, Ed, Sheen, Faye J., Bio, Matthew M., Jos Brands, K.M., Davies, Antony J., Dolling, Ulf-H.

Volltext

Stereoselective double ring closing metathesis reactions in the synthesis of spirocyclic compounds von Wallace, Debra J, Cowden, Cameron J, Kennedy, Derek J, Ashwood, Michael S, Cottrell, Ian F, Dolling, Ulf-H

Volltext

Efficient One-Pot Synthesis of the 2-Aminocarbonylpyrrolidin-4-ylthio-Containing Side Chain of the New Broad-Spectrum Carbapenem Antibiotic Ertapenem von Brands, Karel M. J, Jobson, Ronald B, Conrad, Karen M, Williams, J. Michael, Pipik, Brenda, Cameron, Mark, Davies, Antony J, Houghton, Peter G, Ashwood, Michael S, Cottrell, Ian F, Reamer, Robert A, Kennedy, Derek J, Dolling, Ulf-H, Reider, Paul J

Volltext